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wobble In molecular biology, unorthodox pairing between the base at the 5' end of an anticodon and the base that pairs with it (in the 3'-position of the codon); thus, the anticodon 3'-UCU-5' may pair with 5'-AGA-3' (normal or Watson-Crick pairing) or with 5'-AGG-3' (wobble). Wobble pairings can occur between the unusual base hypoxanthine and adenine, uracil, or cytosine, between uracil and guanine, and between guanine and uracil, when in the 5'-position of an anticodon.
See: wobble base.
(05 Mar 2000)
wobble base The 3' codon base that is less strictly specified in the genetic code.
See: wobble, wobble hypothesis.
(05 Mar 2000)
wobble hypothesis <molecular biology> Explains why the base Inosine is included in position 1 in the anticodons of various t RNAs, why many mRNA codon words translate to a single amino acid, why there are appreciably fewer t RNAs than mRNA codon types and why the redundant nature of the genetic code translates into a precise set of 20 amino acids.
Inosine in Position 1 in the anticodon can base pair with A, u or C in position 3 in the mRNA codon, so that for example UCU, UCC, UCA all code for Serine using an inosine anticodon.
(18 Nov 1997)
base pairing <molecular biology> The specific hydrogen bonding between purines and pyrimidines in double stranded nucleic acids.
In DNA the pairs are adenine and thymine and guanine and cytosine, while in RNA they are adenine and uracil and guanine and cytosine.
Base pairing leads to the formation of a DNA double helix from two complementary single strands.
(15 Nov 1997)
chromosome pairing The process in synapsis whereby homologous chromosome's align opposite each other before disjoining in the formation of the daughter cell; the apposition permits exchange of genetic material in crossing-over.
(05 Mar 2000)
complementary base pairing <molecular biology> The pairing of complementary nucleotide bases (adenine and thymine, guanine and cytosine) to each other via hydrogen bonds from opposite strands of a double stranded nucleic acid (such as DNA or RNA), thereby holding the double-stranded nucleic acid together.
(09 Oct 1997)
ectopic pairing Pairing of heterochromatin randomly, without regard to whether they are homologous.
(09 Oct 1997)
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