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wobble In molecular biology, unorthodox pairing between the base at the 5' end of an anticodon and the base that pairs with it (in the 3'-position of the codon); thus, the anticodon 3'-UCU-5' may pair with 5'-AGA-3' (normal or Watson-Crick pairing) or with 5'-AGG-3' (wobble). Wobble pairings can occur between the unusual base hypoxanthine and adenine, uracil, or cytosine, between uracil and guanine, and between guanine and uracil, when in the 5'-position of an anticodon.
See: wobble base.
(05 Mar 2000)
wobble base The 3' codon base that is less strictly specified in the genetic code.
See: wobble, wobble hypothesis.
(05 Mar 2000)
wobble hypothesis <molecular biology> Explains why the base Inosine is included in position 1 in the anticodons of various t RNAs, why many mRNA codon words translate to a single amino acid, why there are appreciably fewer t RNAs than mRNA codon types and why the redundant nature of the genetic code translates into a precise set of 20 amino acids.
Inosine in Position 1 in the anticodon can base pair with A, u or C in position 3 in the mRNA codon, so that for example UCU, UCC, UCA all code for Serine using an inosine anticodon.
(18 Nov 1997)
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wobble move unsteadily; "His knees wobbled"; "The old cart wobbled down the street" careen: move sideways or in an unsteady way; "The ship careened out of control" an unsteady rocking motion shimmy: tremble or shake; "His voice wobbled with restrained emotion"
Ãâó: wordnet.princeton.edu/perl/webwn
wobbler something that wobbles
Ãâó: wordnet.princeton.edu/perl/webwn
wobble Movement in which the lipid molecule partially dips into the opposite leaflet of the bilayer and then moves back to its original position without changing its longitudinal orientation.
Ãâó: www.nature.com/nrm/journal/v6/n3/glossary/nrm1591_...
wobble In reference to reading the genetic code, the concept that nonstandard base pairing is allowed between the anticodon and the third position of the condon.
Ãâó: www.hardydiagnostics.com/Glossary-W.html
wobbler Wobbler is a neurodegenerative disease model that arose in a laboratory mouse by chance. As it has a very valuable phenotype that mimics ALS and other motor neuron diseases, it was maintained by breeding. As it was a mutation that arose spontaneously, we currently have no information on where in the mouse genome the ALS-producing mutation is present. Currently investigators are trying to identify the location of the mutation in the mouse. ...
Ãâó: www.als.net/als101/glossary.asp
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wobble a rocking motion
wobble move unsteadily
wobble tremble or shake
wobble move sideways or in an unsteady way, as of a ship or a vehicle out of control
wobble something that wobbles
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