| ¿µ¹® | pH, hydrogen ion concentration | ÇÑ±Û | ¼ö¼ÒÀ̿³óµµÁö¼ö |
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| ¼³¸í | Ç÷¾×À̳ª ¼Òº¯¿¡¼ ½Ç½ÃÇÏ´Â °Ë»çÇ׸ñ. pH°Ë»ç´Â ÀÎüÀÇ Ã¼¾×ÀÇ »ê¼º, ¾ËÄ®¸®¼ºÀ» ¾Ë¾Æº¸´Â Áß¿äÇÑ °Ë»çÀÌ´Ù. ÀÎü´Â ¾à¾ËÄ®¸®¼º¿¡ ¼ÓÇϳª, À̺¸´Ù pHÀÇ Áõ°¡³ª °¨¼Ò°¡ ³ªÅ¸³¯ °æ¿ì, »ý¸í¿¡ À§ÇèÀÌ ¹ß»ýÇÑ´Ù. ÀÎü³»¿¡´Â ÀÌ·± »êµµÀÇ Áõ°¨À» ¸·±âÀ§ÇØ, À̸¥¹Ù ¿ÏÃæÁ¦µéÀÌ ¸¹ÀÌ Á¸ÀçÇϸç, ƯÈ÷ ÇãÆÄ¿Í ÄáÆÏÀÌ ¿ÏÃæÀÛ¿ëÀ» ¼öÇàÇÏ´Â ÁÖ¿ä±â°üÀÌ´Ù. ÄáÆÏÀº »êµµ°¡ ³ôÀ» °æ¿ì, ¼Òº¯¿¡¼ »êµµ¸¦ Áõ°¡½ÃÄÑ ¹èÃâÇÔÀ¸·Î½á Ç÷¾×³»ÀÇ ¾ËÄ®¸®¼º ³óµµ°¡ Áõ°¡Çϵµ·Ï ÇÑ´Ù. ¶ÇÇÑ ÇãÆÄ¿¡¼µµ, Ç÷¾×³»¿¡ »êµµ°¡ Áõ°¡½Ã È£ÈíÀ» Áõ°¡ÇÔÀ¸·Î½á ¹ÛÀ¸·Î »êÀÇ ¹èÃâÀ» Áõ°¡½ÃŲ´Ù. ÀÌ·± ÇãÆÄ¿Í ÄáÆÏÀÇ ±ÕÇüÀº ¾ÆÁÖ ÀûÀýÈ÷ ÀÌ·ç¾îÁö°í ÀÖÀ¸¸ç, ¾î´À ÇÑ ±â°üÀÇ ÀÌ»óÀÌ ¹ß»ýÇϸé, ÀÌ·± ±ÕÇüÀº ±ú¾îÁö±â ½±´Ù. |
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| ¿µ¹® | ion | ÇÑ±Û | À̿ |
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| ¼³¸í | ºÐÀÚ¸¦ Àü±âºÐÇØÇÒ ¶§ ºÐ¸®µÇ´Â, Àü±â¸¦ ¶í ¹Ì¸³Àڷμ ¾çÀü±â¸¦ ¶í ¾çÀ̿°ú À½Àü±â¸¦ ¶í À½ÀÌ¿ÂÀÌ ÀÖ´Ù. |
||
| CNGC | cyclic nucleotide gated channel |
|---|---|
| VGCC | voltage-gated calcium channels |
| VSC | Voltage Sensitive Channel |
| VDAC | voltage-dependent anion channel |
| VOCC | voltage-operated calcium channel |
| VGCC | Voltage gated Ca(2+) channel |
|---|---|
| VGCC | voltage gated calcium channel |
| VGSC | voltage-gated sodium channel |
| KATP channel | ATP sensitive potassium channel |
| BK channel | K channel |
channel-shoulder-pin attachment
| voltage gated ion channel | <physiology> A transmembrane ion channel whose permeability to ions is extremely sensitive to the transmembrane potential difference. These channels are essential for neuronal signal transmission and for intracellular signal transduction. See: sodium channel. (18 Nov 1997) |
|---|
| voltage-gated channel | A class of ion channel's that open and close in response to change in the electrical potential across the plasma membrane of the cell; voltage-gated Na+ c.'s are important for conducting action potential along nerve cell processes. (05 Mar 2000) |
|---|---|
| gated ion channel | <physiology> Transmembrane proteins of excitable cells, that allow a flux of ions to pass only under defined circumstances. Channels may be either voltage gated, such as the sodium channel of neurons or ligand gated such as the acetylcholine receptor of cholinergic synapses. Channels tend to be relatively ion specific and allow fluxes of typically 1000 ions to pass in around 1ms, they are thus much faster at moving ions across a membrane than transport ATPases. (05 May 1997) |
| ligand gated ion channel | A transmembrane ion channel whose permeability is increased by the binding of a specific ligand, typically a neurotransmitter at a chemical synapse. The permeability change is often drastic, such channels let through effectively no ions when shut, but allow passage at up to 10exp7 ions sexp 1 when a ligand is bound. Recently, the receptors for both acetylcholine and GABA have been found to share considerable sequence homology, implying that there may be a family of structurally related ligand gated ion channels. (18 Nov 1997) |
| ligand-gated channel | A class of ion channel's whose ionic permeability is regulated by cell membrane receptors that respond to specific extracellular chemical signals. (05 Mar 2000) |
| ion channel | <cell biology> A transmembrane pore that presents a hydrophilic channel for ions to cross a lipid bilayer down their electrochemical gradients. Some degree of ion specificity is usually observed and typically a million ions per second may flow. Channels may be permanently open, like the potassium leak channel or they may be voltage gated, like the sodium channel or ligand gated like the acetylcholine receptor. (27 Oct 1998) |
| ion channel gating | The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability. (12 Dec 1998) |
| voltage | <physics> Electric potential or potential difference, expressed in volts. Source: Websters Dictionary (01 Mar 1998) |
| voltage clamp | <physiology, technique> A technique in electrophysiology, in which a microelectrode is inserted into a cell and current injected through the electrode so as to hold the cells membrane potential at some predefined level. The technique can be used with separate electrodes for voltage sensing and current passing, for small cells, the same electrode can be used for both. Voltage clamp is a powerful technique for the study of ion channels. See: patch clamp. (18 Nov 1997) |
| voltage gradient | <physiology> Literally, the electric field in a region, defined as the potential difference between two points divided by the distance between them. Used more loosely, the potential difference across a plasma membrane. (18 Nov 1997) |
| voltage loop | <radiobiology> A wire which encircles the main axis of a tokamak in the vicinity of the vacuum vessel. The voltage induced in this loop during the shot is a measure of the ohmic heating voltage induced by transformer action and applied to the plasma. (09 Oct 1997) |
| gated blood pool imaging | Radionuclide ventriculography where scintigraphic data is acquired during repeated cardiac cycles at specific times in the cycle, using an electrocardiographic synchroniser or gating device. Analysis of right ventricular function is difficult with this technique; that is best evaluated by first-pass ventriculography (ventriculography, first-pass). (12 Dec 1998) |
| gated radionuclide angiocardiography | Radionuclide angiocardiography using cardiac gating to combine images from several cardiac cycles to improve the quality of the images of separate phases (e.g., systole and diastole). (05 Mar 2000) |
| calcium channel | <physiology> A membrane channel that is specific for calcium. It is a voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorised as l, t, n, or p types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. (12 May 2002) |
| calcium channel agonist | <pharmacology> Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in vascular smooth muscle and/or cardiac muscle cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture. (12 Dec 1998) |
| calcium channel antagonist | <pharmacology> A class of drugs that act by selective inhibition of calcium ion influx through or across cell membranes or on the release and binding of calcium in intracellular pools. Calcium channel blockers are used primarily in the treatment of certain heart conditions and stroke. As they are inducers of vascular and other smooth muscle relaxation, they are also used in the treatment of hypertension and cerebrovascular spasms, as myocardial protective agents, and in the relaxation of uterine spasms. Synonym: calcium antagonist, calcium channel-blocker, slow channel-blocking agent. (12 May 2002) |
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