| VN | vesical neck; vestibular nucleus; virus neutralization; visceral nucleus; visiting nurse; vitronecti... |
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| VNR | vitronectin receptor |
| VNRA | vitronectin receptor alpha |
| VTN | vitronectin |
| VN | Vitronectin |
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| VNR | vitronectin receptor |
| vitronectin | <protein> Serum protein (70 kD) also called serum spreading factor from its activity in promoting adhesion and spreading of tissue cells in culture. Contains the cell binding sequence Arg Gly Asp (RGD) first found in fibronectin. (18 Nov 1997) |
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| receptors, vitronectin | Alpha-v beta-3 integrins that bind vitronectin with high affinity and play a role in cell migration. They also bind fibrinogen, von willebrand factor, osteopontin, and thrombospondin. The highly homologous alpha-v beta-5 integrin also binds vitronectin, but mediates simple adhesion. (12 Dec 1998) |
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Synonyms :
| vitronectin |
a multifunctional adhesive glycoprotein occurring in serum and various tissues and having binding sites for integrins, collagen, heparin, complement components and perforin. Its functions include regulation of the coagulation, fibrinolytic, and complement cascades, and it plays a role in hemostasis, wound healing, tissue remodeling, and cancer. It binds plasminogen activator inhibitor (PAI-1); mediates the inflammatory and repair reactions occurring at sites of tissue injury; and promotes adhesion, spreading, and migration of cells. It has been shown to be identical to S protein, which was identified as an inhibitor of complement activation, binding the membrane attack complex and preventing its insertion into the membrane.
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