| uncoupler | <biochemistry> An agent that can uncouple electron transport from oxidative phosphorylation. Ionophores can do this by discharging the ion gradient across the mitochondrial membrane that is generated by electron transport. In general the term applies to any agent capable of dissociating two linked processes. (18 Nov 1997) |
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| uncouplers | Substances such as dinitrophenol that allow oxidation in mitochondria to proceed without the usual concomitant phosphorylation to produce ATP; these poisons thus "uncouple" oxidation and phosphorylation. Synonym: uncoupling factors. (05 Mar 2000) |
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