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  • ubiquitin
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  • ubiquitin-protease pathway
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  • ubiquitin
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  • ubiquitination
    À¯ºñÄûƾȭ(ûù)
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UBB ubiquitin B
UBE ubiquitin-activating enzyme
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UB Ubiquitin
Ubq Ubiquitin
UBCs Ubiquitin conjugating enzymes
UCRP Ubiquitin cross-reactive protein
UBP ubiquitin-specific protease
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ubiquitin <protein> A protein (8.5 kD) found in all eukaryotic cells. Can be linked to the lysine side chains of proteins by formation of an amide bond to its C terminal glycine in an ATP requiring process.
The protein/ubiquitin complex is subject to rapid proteolysis. Ubiquitin also has a role in the heat shock response.
(18 Nov 1997)
ubiquitin carrier protein kinase <enzyme> A 300 kD kinase consisting of 3 subunits of mws 70, 105 and 120; requires magnesium but inhibited by high concentration; from hela cells
Registry number: EC 2.7.10.-
(26 Jun 1999)
ubiquitin thiolesterase <enzyme> Cleaves c-terminal enzyme s-ubiquitin and c-terminal adenosine 5'-phosphate ubiquitin; uch-8 is also available
Registry number: EC 3.1.2.15
Synonym: ubiquitin c-terminal esterase, ubiquitin carboxy-terminal hydrolase, ubiquitin carboxy-terminal esterase, neuron-specific protein 9.5, pgp 9.5, protein gene product 9.5, uch-l3, ubiquitin c-terminal hydrolase
(26 Jun 1999)
ubiquitin-calmodulin ligase <enzyme> Covalentyl links ubiquitin to bovine calmodulin in an ATP-dependent manner
Registry number: EC 6.3.2.21
Synonym: ubiquityl-calmodulin synthetase
(26 Jun 1999)
ubiquitin-Nalpha-protein hydrolase <enzyme> Cleaves ubiquitin fusion proteins to release ubiquitin and the authentic protein; encoded by gene ubp1 from saccharomyces cerevisiae; amino acid sequence has been determined
Registry number: EC 3.4.99.-
Synonym: ualphap hydrolase, ubiquitin-conjugate peptidase, alpha-nh-ubiquitin protein endoprotease, ubiquitin-specific processing protease, ubp1 protein, ubp1 gene product, yeast ubiquitin hydrolase, yuh1 protein, yuh1 gene product, ubp2 protease, ubp5 gene product, fat facets gene product
(26 Jun 1999)
ubiquitin-protein ligase <enzyme> Consists of 3 enzymes; e1 is ubiquitin activating enzyme; e2 transfers activated ubiquitin as an enzyme-ubiquitin thiol ester to e3, which transfers ubiquitin to an intracellular protein; e1 forms both an enzyme-bound cooh-terminal ubiquitin thiolester and a cooh-terminal ubiquitin-adenylatte; ube1y is putative y function in spermatogonial proliferation; ube1x and ube1y encode the e1 enzyme
Registry number: EC 6.3.2.19
Synonym: ubiquitin-protein ligase system, ubiquitin-protein-lysine n-omega-ligase, ubiquitin-activating enzyme, ubiquitin-activating enzyme e1, ubiquitination activating enzyme e1, ube1 gene product, rsp5 ubiquitin-protein ligase, npi1 protein, ube1y gene product, ube1x gene product, ikappab-ubiquitin ligase
(26 Jun 1999)
ubiquitinoylation <biochemistry> The covalent addition of ubiquitin residues to proteins. Single or multiple residues can be added and bound ubiquitin can also be a site for further addition of ubiquitin residues.
(18 Nov 1997)
CancerWEB ¿µ¿µ ÀÇÇлçÀü À¯»ç °Ë»ö °á°ú : 1 ÆäÀÌÁö: 1
ATP-ubiquitin-dependent proteinase <enzyme> A component of the cytosolic ubiquitin-dependent proteolysis system
Registry number: EC 3.4.-
Synonym: ucden
(26 Jun 1999)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 5 ÆäÀÌÁö: 1
  • Ubiquitin - »õâ A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
    Synonyms : APF-1, ATP-Dependent Proteolysis Factor 1, HMG-20, High Mobility Protein 20, Ubiquitin, Human, ATP Dependent Proteolysis Factor 1, Human Ubiquitin
  • Ubiquitin C - »õâ A single protein comprised of tandem repeats of the UBIQUITIN 78-amino acid sequence. It is a product of the polyubiquitin gene which contains multiple copies of the ubiquitin coding sequence. Proteolytic processing of ubiquitin C results in the formation of individual ubiquitin molecules. This protein is distinct from POLYUBIQUITIN, which is a protein formed through isopeptide linkage of multiple ubiquitin species.
    Synonyms : Polyubiquitin Gene Product
  • Ubiquitin Thiolesterase - »õâ A thioester hydrolase which acts on esters formed between thiols such as DITHIOTHREITOL or GLUTATHIONE and the C-terminal glycine residue of UBIQUITIN.
    Synonyms : Ubiquitin C-Terminal Esterase, Ubiquitin C-Terminal Hydrolase, Ubiquitin Carboxy-Terminal Esterase, Ubiquitin Carboxy-Terminal Hydrolase, C-Terminal Esterase, Ubiquitin, C-Terminal Hydrolase, Ubiquitin, Carboxy-Terminal Esterase, Ubiquitin
  • Ubiquitin-Activating Enzymes - »õâ A class of enzymes that catalyzes the ATP-dependent formation of a thioester bond between itself and UBIQUITIN. It then transfers the activated ubiquitin to one of the UBIQUITIN-PROTEIN LIGASES.
    Synonyms : Ubiquitin-Activating Enzyme, Ubiquitin-Activating Enzyme E1, Ubiquitination Activating Enzyme E1, Enzyme E1, Ubiquitin-Activating, Enzyme, Ubiquitin-Activating, Enzymes, Ubiquitin-Activating, Ubiquitin Activating Enzyme, Ubiquitin Activating Enzyme E1
  • Ubiquitin-Conjugating Enzymes - »õâ A class of enzymes that form a thioester bond to UBIQUITIN with the assistance of UBIQUITIN-ACTIVATING ENZYMES. They transfer ubiquitin to the LYSINE of a substrate protein with the assistance of UBIQUITIN-PROTEIN LIGASES.
    Synonyms : HHR6 Protein, Ubiquitin-Conjugating Enzyme E2, E2, Ubiquitin-Conjugating Enzyme, Enzyme E2, Ubiquitin-Conjugating, Enzymes, Ubiquitin-Conjugating, Ubiquitin Conjugating Enzyme E2, Ubiquitin Conjugating Enzymes
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ubiquitin A 76-amino-acid protein that can be covalently attached to specific lysine residues in target proteins. This often forms multimeric polyubiquitin chains, which is thought to target the protein for destruction.
Ãâó: www.nature.com/nrm/journal/v3/n6/glossary/nrm830_g...
ubiquitin A protein found in all eukaryotic cells that becomes covalently attached to certain residues of other proteins. The attachment of a chain of ubiquitins tags a protein for intracellular proteolytic destruction.
Ãâó: www.bseinquiry.gov.uk/report/volume16/gloss5.htm
ubiquitin a protein involved in the destruction of proteins, tags proteins for degradation
Ãâó: www.ithaca.edu/faculty/jhardwick/Neurobiology/disc...
ubiquitin Ubiquitin is associated with proteins that are about to break down. Their usual function is probably to protect proteins. In many dementias an accumulation of ubiquitinated proteins is found--for example, in Lewy bodies.
Ãâó: www.studentbmj.com/issues/02/08/education/274.php
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