| DABP | D site albumin promoter binding protein |
|---|---|
| ESP | early systolic paradox; echo spacing; effective sensory projection; effective systolic pressure; end... |
| GPE | guinea pig embryo; granulocyte colony-stimulating factor promoter element |
| GPEBP | granulocyte colony-stimulating factor promoter element binding protein |
| AdMLP | Adenovirus major late promoter |
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| Ad2MLP | Adenovirus-2 major late promoter |
| COUP-TF | Chicken Ovalbumin Upstream Promoter Transcription Factor |
| COUP-TFII | Chicken ovalbumin upstream promoter transcription factor II |
| IPF-1 | Insulin promoter factor 1 |
| tumour promoter | <molecular biology, oncology> Agent that in classical studies of carcinogenesis in rodent skin was able to increase the sensitivity of tumour formation by a previously applied primary carcinogen, but was unable to induce tumours when used alone. Important example was croton oil, active ingredients of which are now believed to be phorbol esters. These are believed to act as analogues of diacylglycerols and may activate protein kinase C. Strictly speaking, not the same as a co carcinogen, which is defined as being active when administered at the same time. Tumour promoters generally are carcinogens when tested more stringently. (18 Nov 1997) |
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| constituative promoter | An unregulated promoter that allows for continual transcription of itsassociated gene. (09 Oct 1997) |
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| promoter | <molecular biology> A region of DNA to which RNA polymerase binds before initiating the transcription of DNA into RNA. The nucleotide at which transcription starts is designated +1 and nucleotides are numbered from this with negative numbers indicating upstream nucleotides and positive downstream nucleotides. most bacterial promoters contain two consensus sequences that seem to be essential for the binding of the polymerase. The first, the Pribnow box, is at about 10 and has the consensus sequence 5' TATAAT 3'. The second, the 35 sequence, is centred about 35 and has the consensus sequence 5' TTGACA 3'. most factors that regulate gene transcription do so by binding at or near the promoter and affecting the initiation of transcription. Much less is known about eukaryote promoters, each of the three RNA polymerases has a different promoter. RNA polymerase I recognises a single promoter for the precursor of rRNA. RNA polymerase II, that transcribes all genes coding for polypeptides, recognises many thousands of promoters. most have the Goldberg Hogness or TATA box that is centred around position 25 and has the consensus sequence 5' TATAAAA 3'. Several promoters have a CAAT box around 90 with the consensus sequence 5' GGCCAATCT 3'. There is increasing evidence that all promoters for housekeeping genes contain multiple copies of a GC rich element that includes the sequence 5' GGGCGG 3'. Transcription by polymerase II is also affected by more distant elements known as enhancers. RNA polymerase III synthesises 5s ribosomal RNA, all tRNAs and a number of small RNAs. The promoter for RNA polymerase III is located within the gene either as a single sequence, as in the 5s RNA gene or as two blocks, as in all tRNA genes. (13 Nov 1997) |
| promoter insertion | <molecular biology> Activation of a gene by the nearby integration of a virus. The long-terminal repeat acts as a promoter for the host gene. A form of insertional mutagenesis. (18 Nov 1997) |
| promoter regions | <genetics> DNA sequences which are recognised (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the pribnow box in bacteria and the tata box in eukaryotes. (12 Dec 1998) |
| down promoter mutation | <molecular biology> A mutation (a change in base pair sequence) in a promoter region, this results in lower gene expression (less transcription of the gene occurs). (09 Oct 1997) |
| up promoter mutation | A mutation that increases the frequency of initiation of transcription. (05 Mar 2000) |
| acinar cell tumour | A solid and cystic tumour of the pancreas, occurring in young women; tumour cells contain zymogen granules. (05 Mar 2000) |
| acute splenic tumour | Acute splenitis, enlargement, and softening of the spleen, usually due to bacteraemia or severe bacterial toxaemia. (05 Mar 2000) |
| adenoid tumour | Adenoma, or neoplasm with glandlike spaces. (05 Mar 2000) |
| adenomatoid odontogenic tumour | A benign epithelial odontogenic tumour appearing radiographically as a well-circumscribed radiolucent-radiopaque lesion usually surrounding the crown of an impacted tooth in an adolescent or young adult; characterised histologically by columnar cells organised in a duct-like configuration interspersed with spindle-shaped cells and amyloid-like deposition that gradually undergoes dystrophic calcification. Synonym: adenoameloblastoma, ameloblastic adenomatoid tumour. (05 Mar 2000) |
| adenomatoid tumour | A small, circumscribed, benign tumour of the genital tract, composed of small glandlike spaces lined by flattened or cuboidal mesothelium-like cells. (12 Dec 1998) |
| adipose tumour | <oncology, tumour> Clumps of fat cells. Literally, fat cancer. These are benign tumours that can form in the breast. (16 Dec 1997) |
| adrenal gland tumour | <oncology> A benign tumour or adenoma, that usually results in the excess production of adrenal gland hormones. (27 Sep 1997) |
| adrenal rest tumour | A rare, usually benign, ovarian tumour thought to be derived from embryonic rest cells of the adrenals. This tumour causes various degrees of masculinization. (12 Dec 1998) |
| ameloblastic adenomatoid tumour | A benign epithelial odontogenic tumour appearing radiographically as a well-circumscribed radiolucent-radiopaque lesion usually surrounding the crown of an impacted tooth in an adolescent or young adult; characterised histologically by columnar cells organised in a duct-like configuration interspersed with spindle-shaped cells and amyloid-like deposition that gradually undergoes dystrophic calcification. Synonym: adenoameloblastoma, ameloblastic adenomatoid tumour. (05 Mar 2000) |
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