| TMP | thiamine monophosphate; thymidine monophosphate; thymidine-5'-monophosphate; thymolphthalein monopho... |
|---|---|
| CFTR | cystic fibrosis transmembrane conductance regulator |
| LESTR | leukocyte-derived seven-transmembrane domain receptor |
| TAP | transesophageal atrial pacing; transluminal angioplasty; transmembrane action potential; transporter... |
| TPG | transmembrane potential gradient; transplacental gradient; tryptophan peptone glucose [broth] |
| KATP channel | ATP sensitive potassium channel |
|---|---|
| BK channel | K channel |
| TM | 6-transmembrane |
| CFTR | CF transmembrane conductance regulator |
| CFTR | Cystic Fibrosis Transmembrane Conductance Regulator |
channel-shoulder-pin attachment
| cystic fibrosis transmembrane conductance regulator | Gene believed to be defective in cystic fibrosis. Gene encodes a chloride channel, homologous to a family of proteins that actively transport small solutes in an ATP dependent manner (ABC transporters). The regulator protein is a protein which is embedded in the cell membrane and acts as a channel for certain ions to be transported into or out of the cell. The disease cystic fibrosis is caused by a defect in the gene for this protein. (09 Oct 1997) |
|---|---|
| hepatoma transmembrane kinase | <enzyme> A transmembrane tyrosine kinase of the eph subfamily; genbank u07695 Registry number: EC 2.7.1.- Synonym: htk protein, htk gene product (26 Jun 1999) |
| transmembrane | Through or across a membrane. (05 Mar 2000) |
| transmembrane potential | <physiology> More correctly, transmembrane potential difference: the electrical potential difference across a plasma membrane. See: resting potential, action potential. (18 Nov 1997) |
| transmembrane protein | <cell biology> A protein subunit in which the polypeptide chain is exposed on both sides of the membrane. The term does not apply when different subunits of protein complex are exposed at opposite surfaces. most integral membrane proteins are also transmembrane proteins. (13 Nov 1997) |
| transmembrane transducer | A system that transmits a chemical or electrical signal across a membrane. Usually involves a transmembrane receptor protein that is thought to undergo a conformation change that is expressed on the inner surface of the membrane. Many such transducing species are dimeric and the conformation change may involve interaction between the two components. (18 Nov 1997) |
| calcium channel | <physiology> A membrane channel that is specific for calcium. It is a voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorised as l, t, n, or p types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. (12 May 2002) |
| calcium channel agonist | <pharmacology> Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in vascular smooth muscle and/or cardiac muscle cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture. (12 Dec 1998) |
| calcium channel antagonist | <pharmacology> A class of drugs that act by selective inhibition of calcium ion influx through or across cell membranes or on the release and binding of calcium in intracellular pools. Calcium channel blockers are used primarily in the treatment of certain heart conditions and stroke. As they are inducers of vascular and other smooth muscle relaxation, they are also used in the treatment of hypertension and cerebrovascular spasms, as myocardial protective agents, and in the relaxation of uterine spasms. Synonym: calcium antagonist, calcium channel-blocker, slow channel-blocking agent. (12 May 2002) |
| calcium channel-blocker | <pharmacology> A class of drugs that act by selective inhibition of calcium ion influx through or across cell membranes or on the release and binding of calcium in intracellular pools. Calcium channel blockers are used primarily in the treatment of certain heart conditions and stroke. As they are inducers of vascular and other smooth muscle relaxation, they are also used in the treatment of hypertension and cerebrovascular spasms, as myocardial protective agents, and in the relaxation of uterine spasms. Synonym: calcium antagonist, calcium channel-blocker, slow channel-blocking agent. (12 May 2002) |
| gated ion channel | <physiology> Transmembrane proteins of excitable cells, that allow a flux of ions to pass only under defined circumstances. Channels may be either voltage gated, such as the sodium channel of neurons or ligand gated such as the acetylcholine receptor of cholinergic synapses. Channels tend to be relatively ion specific and allow fluxes of typically 1000 ions to pass in around 1ms, they are thus much faster at moving ions across a membrane than transport ATPases. (05 May 1997) |
| voltage-gated channel | A class of ion channel's that open and close in response to change in the electrical potential across the plasma membrane of the cell; voltage-gated Na+ c.'s are important for conducting action potential along nerve cell processes. (05 Mar 2000) |
| voltage gated ion channel | <physiology> A transmembrane ion channel whose permeability to ions is extremely sensitive to the transmembrane potential difference. These channels are essential for neuronal signal transmission and for intracellular signal transduction. See: sodium channel. (18 Nov 1997) |
| channel | A furrow, gutter, or groovelike passageway. See: canal. Origin: L. Canalis (05 Mar 2000) |
| channel forming ionophore | <chemistry> An ionophore that makes an amphipathic pore with hydrophobic exterior and hydrophilic interior. most known types are cation selective. (18 Nov 1997) |
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