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G(t) G protein transducin
T Transducin
alpha T alpha subunit of transducin
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transducin <protein> A GTP-binding protein found in the disc membrane of retinal rods and cones: of the part of the cascade involved in transduction of light to a nervous impulse.
A complex of three subunits, alpha (39 kD), beta (36 kD) and gamma (8 kD). Photoexcited rhodopsin interacts with transducin and promotes the exchange of GTP for GDP on the _ subunit.
The GTP _ subunit dissociates from the complex and activates a cGMP phospodiesterase by removing an inhibitory subunit. The _ subunit of transducin can be ADP ribosylated by cholera toxin and pertussis toxin.
(18 Nov 1997)
transducin GTP phosphohydrolase <enzyme> Stimulated by bovine rhodopsin mutants (asp63 to asn) and (glu134 to gln) with slightly lowered efficiency
Registry number: EC 3.6.1.-
Synonym: transducin GTPase
(26 Jun 1999)
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  • Transducin - »õâ A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells. EC 3.6.1.-.
    Synonyms : Transducin G-Protein (Gt), Transducin, alpha Subunit, Transducin, beta Subunit, Transducin, gamma Subunit, G Protein, Inhibitory Gt, G-Protein Gt, Transducin, Gt G-Protein, Inhibitory, Gt, Transducin G Protein, Inhibitory Gt G-Protein, Transducin G-Protein Gt
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transducin a G protein of the disk membrane of the retinal rods that interacts with activated rhodopsin and participates in the triggering of a nerve impulse in vision; it stimulates hydrolysis of cyclic guanosine monophosphate, beginning the cascade that closes specific ion channels and generates an action potential.
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transducin a vector for delivering genes into cells
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