| ECG | Electro-Cardio-Graphy(-Gram); ½ÉÀüµµ = EKG 1. Conducting System Structu... |
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| abs | conf absolute configuration |
| CFA | colonization factor antigen; colony-forming assay; complement-fixing antibody; complete Freund's adj... |
| OTC | Ornithine Trans-Carbamylase |
| PTHC | Percutaneous Trans-Hepatic Cholangiography(-gram) = PTC |
| ALL-Trans RA | ALL-Trans Retinoic acid |
|---|---|
| tt-MA | Trans, trans-muconic acid |
| trans-ACPD | Trans-1-amino-1,3-cyclopentanedicarboxylic acid |
| AMCHA | 4/trans-(aminomethyl)cyclohexanecarboxylic acid |
| ATRA | All Trans Retinoic Acid |
| trans configuration | 1. <chemistry> The configuration of an organic molecule containing a double bond between two carbon atoms, where the largest, most complex R groups attached to each carbon are on opposite sides. Alternatively: The configuration of an organic molecule containing a ring, where the largest, most complex R groups attached to each carbon are on opposite sides. These configurations are the opposite of cis configuration. 2. <genetics> A genetics term meaning that the changes in gene expression are due to something acting on the gene from a distance, or from an unrelated location, rather than on the same strand of DNA. Two mutations in different genes coding for the same phenotype which are on opposite homologous chromosomes (as opposed to the cis configuration where both of the mutations are on the same homologue). (17 Mar 1998) |
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| absolute configuration | <chemistry> The three-dimensional arrangement of the atoms around the chiral centre of a molecule. (09 Oct 1997) |
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| cis configuration | <molecular biology> The configuration of an organic molecule containing a double bond between two carbon atoms, where the largest, most complex R groups are on the same side: H H \ / C=C / \ H3C CH3 -OR-The configuration of an organic molecule containing a ring, where the largest, most complex R groups are on the same side: H H | ___ \ / | // \\ [ring viewed edge-on] | \___/ / \ | /---\ H3C CH3 | H3C CH3. A genetics term meaning an event or a gene whose action occurs on the same chromosome. Two mutations in different genes coding for the same phenotype which are on the same chromosome (as opposed to the trans configuration where each homologue has one of the mutations). Compare: trans configuration. (11 Jan 1998) |
| configuration | <chemistry> The three-dimensional arrangement of an organic molecule that is caused by: double bonds that prevent free rotation, or chiral centres that haveside groups arranged around them in a particular order. A configurational isomer cannot be turned into another configuration without breaking covalent bonds. (09 Oct 1997) |
| stereochemical configuration | <chemistry> The arrangement of atoms in a molecule in three-dimensional space, especially with regard to the differences between enantiomers. The arrangements are specified in chemical formulas with the letters R, S, L, and/or D. In the R, S system, each asymmetric carbon atom is classified as R (for rectus, Latin for right) if the chemical groups attached to it have decreasing priorities in a clockwise direction, or S (for sinister, Latin for left) if the chemical groups attached to it have decreasing priorities in a counterclockwise direction, when the carbon atom in question is viewed along the bond of the chemical group with the lowest priority. Priorities are assigned to chemical groups according to the Cahn-Ingold Prelog priority rules (generally, the larger the group the higher the priority). L and D designations are given if the enantiomers have optical activity, that is, if they will rotate polarized light. The member of the pair which rotates polarized light clockwise is dextrorotatory, or D, and the member of the pair which rotates polarized light counterclockwise is levorotatory, or L (there is always one of each in every pair). This is also often referred to as handedness, where D is right-handed and L is lefthanded. (13 Nov 1997) |
| degenerate configuration | <radiobiology> Magnetic field configuration in which the magnetic lines of force close exactly on themselves after passing around the configuration a finite number of times. (09 Oct 1997) |
| field-reversed configuration | <radiobiology> A compact torus produced in a theta pinch and having (in principle) no toroidal field. The potential advantages for a fusion reactor include a simple (linear) machine geometry, an average plasma pressure close to the confining field pressure, and physical separation of formation and burn chambers. The are predicted to be violently unstable to tilting, but this is rarely observed. (09 Oct 1997) |
| all-trans-retinal | The orange retinaldehyde resulting from the action of light on the rhodopsin of the retina, which converts the 11-cis-retinal component of the rhodopsin to all-trans-retinal plus opsin. Synonym: trans-retinal, visual yellow. (05 Mar 2000) |
| peptidyl prolyl cis trans isomerase | See: PPIase and immunophilin. (18 Nov 1997) |
| cis-9,trans-11-octadecadienoate reductase | <enzyme> Uses NADH and alpha-tocopherol quinol; forms trans-11-octadecenoate Registry number: EC 1.3.1.- Synonym: 9,11-ocdd reductase (26 Jun 1999) |
| cis-trans-isomerases | <enzyme> Enzymes that catalyze the rearrangement of geometry about double bonds. Registry number: EC 5.2 (12 Dec 1998) |
| cis trans test | <molecular biology> The complementation test with two or more interacting genes placed in cis and in trans relationships to each other. A double mutant genome is used in the cis test made from the two single mutant genomes used in the trans test by recombination. If the wild type phenotype is restored by both cis and trans arrangements it is concluded that the two mutations are in different genes and hence that the phenotype is determined by more than one gene. If the trans test is negative and the cis positive this means that the two mutations are in the same gene. If both tests are negative then at least one of the mutations must be dominant. Thus the double test provides a means of fine mapping of genes. A lab test which is used to determine whether two mutations of different genes which affect the same phenotype are on the same functional unit (indicating a cis configuration of the mutated genes) or on different functional units (indicating a trans configuration of the mutated genes). (A functional unit can be a chromosome.) The test is done by mating an individual that has one of the mutations to an individual that has the other one, and observing whether their offspring have the mutant phenotype. If the offspring do not have the mutant phenotype, then the genes are known to be trans, because the offspring have normal copies of each mutant gene on the different functional units which are able to genetically complement each other. If the offspring do have the mutant phenotype, then the genes are known to be cis, because the offspring will always inherit at least one of the mutant genes on the one functional unit, resulting in the mutant phenotype. (09 Oct 1997) |
| trans- | 1. Prefix denoting across, through, beyond; opposite of cis-. 2. In genetics, denoting the location of two genes on opposite chromosomes of a homologous pair. 3. In organic chemistry, a form of geometric isomerism in which the atoms attached to two carbon atoms, joined by double bonds, are located on opposite sides of the molecule. 4. In biochemistry, a prefix to a group name in an enzyme name or a reaction denoting transfer of that group from one compound to another; e.g., transformylase (transfers a formyl group), transpeptidation. Origin: L. Trans, through, across (05 Mar 2000) |
| trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | <enzyme> Rat liver cytosol enzyme also catalyses 3alpha-hydroxysteroid dehydrogenase activity (EC 1.1.1.50); bphb isolated from pseudomonas Registry number: EC 1.3.1.20 Synonym: acenaphthenol oxidase, dihydrodiol dehydrogenase, bphb gene product, biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (26 Jun 1999) |
| trans-2-hydroxybenzylidenepyruvate hydratase-aldolase | <enzyme> Catalyses the hydration of cis-o-hydroxybenzylidenepyruvate with subsequent cleavage to form salicylaldehyde--important steps in the bacterial degradation of naphthalene to salicylate Registry number: EC 4.2.1.- Synonym: trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, thbpa hydratase-aldolase (26 Jun 1999) |
| trans-3-chloroacrylic acid dehalogenase | <enzyme> Specific for conversion of trans-3-chloroacrylic acid to muconic saemialdehyde (3-oxopropionic acid); 34 amino-terminal amino acid sequence, with 3 questionable aas, given in first source Registry number: EC 3.8.1.- Synonym: trans-3caa dehalogenase (26 Jun 1999) |
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