| topoisomerase | <enzyme> That change the degree of supercoiling in DNA by cutting one or both strands. Type I topoisomerases cut only one strand of DNA, type I topoisomerase of E. Coli (omega protein) relaxes negatively supercoiled DNA and does not act on positively supercoiled DNA. Type II topoisomerases cut both strands of DNA, type II topoisomerase of E. Coli (DNA gyrase) increases the degree of negative supercoiling in DNA and requires ATP. It is inhibited by several antibiotics, including nalidixic acid and ovobiocin. (18 Nov 1997) |
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| topoisomers | Different forms of a closed, circular DNA molecule, in each, only thelinking number differs. (09 Oct 1997) |
| topoisomerase |
Topoisomerases (type I: EC 5.99.1.2, type II: EC 5.99.1.3) are enzymes that act on the topology of DNA. The double-helical configuration that DNA strands naturally reside in makes them difficult to separate, and yet they must be separated by helicase proteins if other enzymes are to transcribe the sequences that encode proteins, or if chromosomes are to be replicated. ...
Ãâó: en.wikipedia.org/wiki/Topoisomerase
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| topoisomer |
a DNA molecule that differs from another only in linking number, the number of times one strand of the helix wraps around the other in a right hand direction.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
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