| TPA | tannic acid, polyphosphomolybdic acid, and amino acid; 12-0-tetradecanoyl-phorbol-13-acetate; third-... |
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| PMA | index of prevalence and severity of gingivitis, where P = papillary gingiva, M = marginal gingiva, a... |
| CAP | camptodactyly-arthropathy-pericarditis [syndrome]; Canada Assistance Plan; capsule; captopril; catab... |
| MPA | mean pulmonary arterial [pressure]; medial preoptic area; Medical Procurement Agency; medroxyprogest... |
| DOCA | De-Oxy-Corticosterone Acetate |
| TPA | 1,2-tetradecanoyl-phorbol-13-acetate |
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| TPA | 12-0-Tetradecanoyl-13-Phorbol-Acetate |
| TRE | 12-O-tetradecanoyl-phorbol-13-acetate responsive element |
| TPA | Tetradecanoyl Phorbol Acetate |
| RPA | 12-O-retinoyl phorbol 13-acetate |
| phorbol | The parent alcohol of the cocarcinogens, which are 12,13(9,9a) diesters of phorbol found in croton oil; the hydrocarbon skeleton is a cyclopropa-benzazulene; phorbol esters mimic 1,2-diacylglycerol as activators of protein kinase C. (05 Mar 2000) |
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| phorbol 12,13-dibutyrate | <chemical> 1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro 4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl) 1,1,6,8-tetramethyl-5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one butanoic acid diester. A phorbol ester found in croton oil which, in addition to being a potent skin tumour promotor, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase c). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems. Pharmacological action: carcinogens. Chemical name: Butanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diyl ester, (1aR-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha))- (12 Dec 1998) |
| phorbol ester | <chemical> Polycyclic compound isolated from croton oil in which two hydroxyl groups on neighbouring carbon atoms are esterified to fatty acids. The commonest of these derivatives is phorbol myristoyl acetate (PMA). Potent co carcinogens or tumour promotors, they are diacyl glycerol analogues and activate protein kinase C irreversibly. (31 Dec 1997) |
| phorbol esters | <chemical> Tumour-promoting compounds obtained from croton oil (croton tiglium). Some of these are used in cell biological experiments as activators of protein kinase c. Pharmacological action: carcinogens. (12 Dec 1998) |
| acetate | <biochemistry> A salt or ester of acetic acid, specifically, a synthetic textile fibre made from partially hydrolysed cellulose acetate, or a plastic-like film made from cellulose triacetate. The terminal hydrogen atom in the molecule is replaced by a metal, for instance copper acetate, or where substitution is by a radical, for instance ethyl acetate. (04 Jul 1999) |
| acetate-CoA ligase | <enzyme> An enzyme that catalyses the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. Chemical name: Acetate:CoA ligase (AMP-forming) Registry number: EC 6.2.1.1 (12 Dec 1998) |
| acetate kinase | <enzyme> An enzyme that catalyses reversibly the phosphorylation of acetate in the presence of a divalent cation and ATP with the formation of acetylphosphate and ADP. It is important in the glycolysis process. Chemical name: ATP:acetate phosphotransferase Registry number: EC 2.7.2.1 (12 Dec 1998) |
| acetate replacement factor | <biochemistry> 1,2 dithiolane 3 valeric acid. Regarded as a coenzyme in the oxoglutarate dehydrogenase complex of the citric acid cycle. Involved generally in oxidative decarboxylations of _ keto acids. A growth factor for some organisms. (18 Nov 1997) |
| acetate-succinate CoA-transferase | <enzyme> Tritichomonas and trichomonas enzyme converts acetyl-CoA and succinate to acetate and succinyl-CoA Registry number: EC 2.8.3.- Synonym: acetate-succinate coenzyme a-transferase (26 Jun 1999) |
| acetate thiokinase | A ligase that catalyses the reaction of acetate and CoA and ATP to form AMP, pyrophosphate, and acetyl-CoA. A key step in the activation of acetate. Synonym: acetate thiokinase, acetate-CoA ligase, acetyl-activating enzyme, acetyl-CoA synthetase. (05 Mar 2000) |
| active acetate | <enzyme> Condensation product of coenzyme A and acetic acid, symbolised as CoAS~COCH3; intermediate in transfer of two-carbon fragment, notably in its entrance into the tricarboxylic acid cycle and in fatty acid synthesis. This coenzyme plays a huge role in intermediary metabolism, in which cells synthesise, break down or use nutrient molecules for energy production, growth, etc. Acetyl-coenzyme A synthase is found in bacteria and plants and catalyses the reaction in which acetate enters metabolic pathways and forms acetyl-coenzyme A. Synonym: acetyl-coenzyme A, active acetate. (05 Mar 2000) |
| aluminum acetate | Used as a disinfectant by embalmers; proposed as desiccant and deodorant powder for eczema and chronic skin ulcers. (05 Mar 2000) |
| anagestone acetate | 17-Hydroxy-6alpha-methylpregn-4-en-20-one acetate;a progestational agent. (05 Mar 2000) |
| bisoxatin acetate | 2,2-Bis(p-hydroxyphenyl)-2H-1,4-benzoxazin-3(4H)-one diacetate;a laxative. (05 Mar 2000) |
| versiconal hemiacetal acetate esterase | <enzyme> Converts versiconal hemiacetal acetate to versiconal; the first step in biosynthesis of versicolorin b and versicolorin a Registry number: EC 3.1.1.- Synonym: vha esterase (26 Jun 1999) |
| tetradecanoyl phorbol acetate |
a phorbol ester that is a cancer promoter and is used to produce skin cancer in laboratory animals.
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
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