| poly-IC, | poly-I:C copolymer of polyinosinic and polycytidylic acids; synthetic RNA polymer |
|---|---|
| mRNA | messenger Ribo-Nucleic Acid |
| RNA | Ribo-Nucleic Acid |
| CSL | cardiolipin synthetic lecithin; corticosteroid liposome |
| HARS | histidyl-RNA synthetase |
| mRNA | E-messenger RNA |
|---|---|
| pre-mRNA | pre-messenger RNA |
| pre-mRNA | precursor messenger RNA |
| D RNA | defective RNA |
| HCV RNA | Hepatitis C virus RNA |
| masked messenger RNA | <molecular biology> Long lived and stable mRNA found originally in the oocytes of echinoderms and constituting a store of maternal information for protein synthesis that is unmasked (derepressed) during the early stages of morphogenesis. In these early stages the rate of cell division is so rapid that transcription from the embryonic genome cannot occur. Undoubtedly not restricted to oocytes and the term can be applied to any mRNA which is present in inactive form. (18 Nov 1997) |
|---|---|
| messenger-like RNA | An ill-defined form of RNA, of high molecular weight, that never leaves the nucleus and is thought to be the precursor of messenger RNA. (05 Mar 2000) |
| messenger RNA | <molecular biology> Single stranded RNA molecule that specifies the amino acid sequence of one or more polypeptide chains. This information is translated during protein synthesis when ribosomes bind to the mRNA. In prokaryotes, mRNA is normally formed by splicing a large primary transcript from a DNA sequence and protein synthesis starts while the mRNA is still being synthesised. Prokaryote mRNAs are usually very short lived (average t 1/2 is 5mins.). In contrast, in eukaryotes the primary transcripts (HnRNA) are synthesised in the nucleus and they are extensively processed to give the mRNA that is exported to the cytoplasm where protein synthesis takes place. This processing includes the addition of a 5' 5' linked 7 methyl guanylate cap at the 5' end and a sequence of adenylate groups at the 3' end, the poly A tail, as well as the removal of any introns and the splicing together of exons, only 10% of HnRNA leaves the nucleus. Eukaryote mRNAs are comparatively long lived with a half life ranging from 30minutes to 24 hours. (27 Jun 1999) |
| messenger | 1. That which carries a message. 2. Having message-carrying properties. First messenger, a hormone that binds to a receptor on the surface cell and, in so doing, communicates with intracellular metabolic processes. Second messenger, an intermediary molecule that is generated as a consequence of hormone-receptor interaction; e.g., see adenosine 3',5'-cyclic monophosphate; guanosine 3',5'-cyclic monophosphate; calcium; inositide. (05 Mar 2000) |
| second messenger | <molecular biology> In many hormone sensitive systems the systemic hormone does not enter the target cell but binds to a receptor and indirectly affects the production of another molecule within the cell, this diffuses intracellularly to the target enzymes or intracellular receptor to produce the response. This intracellular mediator is called the second messenger. Examples include cyclic AMP, cyclic GMP, IP3 and diacylglycerol. (18 Nov 1997) |
| second messenger systems | Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a hormone or neurotransmitter. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-cyclic AMP system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the cyclic GMP system. (12 Dec 1998) |
| androgens, synthetic | Compounds obtained by chemical synthesis which possess masculinizing activities, but differ in structure from naturally occurring androgens. (12 Dec 1998) |
| vaccines, synthetic | Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified. (12 Dec 1998) |
| genes, synthetic | Biologically functional sequences of DNA chemically synthesised in vitro. (12 Dec 1998) |
| glucocorticoids, synthetic | <chemical> Synthetic chemical compounds which increase gluconeogenesis, raising the concentration of liver glycogen and blood sugar, but differ in structure from naturally occurring glucocorticoids. Pharmacological action: steroidal anti-inflammatory agents, topical anti-inflammatory agents. (12 Dec 1998) |
| resins, synthetic | Polymers of high molecular weight which at some stage are capable of being molded and then harden to form useful components. (12 Dec 1998) |
| mineralocorticoids, synthetic | Synthetic steroids that mimic the activity of the mineralocorticoids obtained from the adrenal cortex, but differ in structure from the naturally occurring mineralocorticoids. (12 Dec 1998) |
| contraceptives, oral, synthetic | Oral contraceptives which owe their effectiveness to synthetic preparations. (12 Dec 1998) |
| contraceptives, postcoital, synthetic | Postcoital contraceptives which owe their effectiveness to synthetic preparations. (12 Dec 1998) |
| progestational hormones, synthetic | Compounds obtained by chemical synthesis that possess progestational activity, but differ in structure from naturally occurring progestational hormones. (12 Dec 1998) |
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