| FS | factor of safety; Fanconi syndrome; Felty syndrome; fibromyalgia syndrome; field stimulation; Fisher... |
|---|---|
| GnRH | Gonadotropin Releasing Hormone [HP 1898, 2034] = LHRH = Go... |
| CMS | children's medical services; Christian Medical Society; chronic myelodysplastic syndrome; chromosome... |
| DABP | D site albumin promoter binding protein |
| E* | lesion on the erythrocyte cell membrane at the site of complement fixation |
| Site 1 | site |
|---|---|
| 5' SS | 5' splice site |
| DBP | D site binding protein |
| ESI | Exit-site infection |
| ESAG | expression site-associated gene |
| switching site | The break point in a DNA sequence at which a gene segment unites with another gene segment, as in the production of the immunoglobulins. (05 Mar 2000) |
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| antigenic switching | <immunology> The process by which a pathogenic microbe's genetic structure is altered tochange its surface antigens inorder to avoid being detected by the host's immune system. (09 Oct 1997) |
|---|---|
| magnetic switching | <radiobiology> The use as switches of saturable inductors for producing high power pulses without electrical arcs. This is a principal technology for extending single-shot accelerators in light-ion-beam-driven inertial confinement fusion to repetitively pulsed devices for possible reactors. Three terawatt, 200 KJ magnetic switches have been developed for fusion drivers at Sandia National Laboratories. (Info from the 1985 OSTI Glossary of Fusion Energy, may be out of date.) (09 Oct 1997) |
| switching | 1. Making a shift or exchange. 2. The movement of a defined region of DNA within a genome. Class switching, a change in the expression of the C region of an immunoglobulin heavy chain. (05 Mar 2000) |
| immunoglobulin class switching | Gene rearrangement of the b-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing. (12 Dec 1998) |
| isotype switching | <immunology> The switch of immunoglobulin isotype that occurs, for example: as the immune response progresses (IgM to IgG). The switch from IgM to IgG involves only the constant region of the heavy chains (from _ to _), the light chain and variable regions of the heavy chain remaining the same and involves the switch regions, upstream (on the 5'side) of the constant region genes, at which recombination occurs. Similarly, IgM and IgD with the same variable region of the heavy chain, but with different heavy chain constant regions (_ and _), seem to coexist on the surface of some lymphocytes. (18 Nov 1997) |
| acceptor site | The ribosomal binding site for the aminoacyl-tRNA during protein synthesis. (05 Mar 2000) |
| acceptor splicing site | Boundary between the right end of an intron and the left end of the adjacent exon. Synonym: acceptor splicing site. (05 Mar 2000) |
| active site | <chemistry> A specific region of an enzyme where a substrate binds and catalysis takes place (binding site). (06 May 1997) |
| allosteric site | A specific site on a multi-subunit enzyme or other protein that is not the substrate binding site, but that when reversibly bound by an effector, induces a conformational change in the protein, altering its catalytic or binding properties. (12 Dec 1998) |
| amidation site | <molecular biology> A C terminus consensus sequence, required for C terminus amidation of peptides. Consensus is glycine, followed by 2 basic amino acids (arg or lys). (18 Nov 1997) |
| antibody combining site | <immunology> In immune network theory, an idiotope, an antigenic site of an antibody that is responsible for that antibody binding to an antigenic determinant (epitope). Also used of the site on a ligand molecule to which a cell surface receptor binds. (18 Nov 1997) |
| antigen-binding site | <immunology> In immune network theory, an idiotope, an antigenic site of an antibody that is responsible for that antibody binding to an antigenic determinant (epitope). Also used of the site on a ligand molecule to which a cell surface receptor binds. (18 Nov 1997) |
| antigen-combining site | See: paratope. (05 Mar 2000) |
| apurinic site | <molecular biology> Sites in DNA from which purines have been lost by cleavage of the deoxy ribose N glycosidic linkage. (18 Nov 1997) |
| apyrimidinic site | <molecular biology> A site on DNA where a base is missing, in this case a pyrimidine (either cytosine or thymine), but the phosphodiester backbone is still intact. Compare: apurinic site. (09 Oct 1997) |
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