| vSAG | viral superantigen |
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| superantigen | <immunology> Antigens, mostly from bacterial toxins, that interact with a set of T lymphocytes bearing a set of products of the V_T receptor genes, as a consequence superantigens activate large numbers of T-cells. Staphylococcal enterotoxins are the best known superantigens and stimulate CD4 T-cells in humans. The Mls gene product in mice can act as a superantigen. (19 Jan 1998) |
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| superantigens | Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions. (12 Dec 1998) |
Synonyms :
| superantigen |
An antigen that activates a large percentage of T-lymphocytes.
Ãâó: www.genpromag.com/Glossary~LETTER~S.html
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| superantigen |
An antigen that interacts with the T cell receptor in a domain outside of the antigen recognition site. This type of interaction induces the activation of larger numbers of T cells compared to antigens that are presented in the antigen recognition site.
Ãâó: www.nbc-med.org/SiteContent/MedRef/OnlineRef/Field...
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| superantigen |
Investigators have proposed that a molecule known as a superantigen, either made by HIV or an unrelated agent, may stimulate massive quantities of CD4+ T cells at once, rendering them highly susceptible to HIV infection and subsequent cell death. See also Antigen; CD4 (T4) or CD4+ Cells.
Ãâó: www.aidsinfobbs.org/letters/s.html
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