| RI | radiation intensity; radioactive isotope; radioimmunology; recession index; recombinant inbred [stra... |
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| EIC | elastase inhibition capacity; enzyme inhibition complex |
| LAI | latex particle agglutination inhibition; leukocyte adherence inhibition |
| ASP | abnormal spinal posture; acute symmetric polyarthritis; African swine pox; aged substrate plasma; al... |
| BSS | Bachelor of Sanitary Science; balanced salt solution; Bernard-Soulier syndrome; black silk suture; b... |
| CAS | Crk-associated substrate |
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| IRS | Insulin Receptor Substrate |
| IRS-2 | Insulin receptor substrate 2 |
| MARCKS | Myristolated Alanine-Rich C-Kinase Substrate |
| PRS | Plasma Renin Substrate |
zymologist
cyto-inhibition
| substrate inhibition | Inhibition of an enzyme activity by a substrate of the reaction catalyzed by that enzyme; often, this type of inhibition occurs at elevated substrate levels in which the substrate is binding to a second, non-active site on the enzyme. (05 Mar 2000) |
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| substrate | <chemistry> A substance upon which an enzyme acts. Origin: L. Stratum = layer (18 Nov 1997) |
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| substrate cycle | <biochemistry> Any seqence of enzyme catalysed reactions in which the forward and reverse processes (catalysed by different enzymes) are consititutively active. Frequently used to describe the cycle of phosphorylation and dephosphorylation of phosphatidyl inositol derivatives in cell membranes. (05 Jan 1998) |
| substrate cycling | A set of opposing, nonequilibrium reactions catalyzed by different enzymes which act simultaneously, with at least one of the reactions driven by ATP hydrolysis. The results of the cycle are that ATP energy is depleted, heat is produced and no net substrate-to-product conversion is achieved. Examples of substrate cycling are cycling of gluconeogenesis and glycolysis pathways and cycling of the triglycerides and fatty acid pathways. Rates of substrate cycling may be increased many-fold in association with hypermetabolic states resulting from severe burns, cold exposure, hyperthyroidism, or acute exercise. (12 Dec 1998) |
| substrate-level phosphorylation | Synthesis of high-energy phosphate bonds through reaction of inorganic phosphate with an activated (usually) organic substrate. (09 Oct 1997) |
| substrate specificity | A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts. (12 Dec 1998) |
| suicide substrate | A competitive inhibitor that is converted to an irreversible inhibitor at the active site of the enzyme. Synonym: mechanism-based inhibitor. (05 Mar 2000) |
| insulin receptor substrate-1 protein | <chemical> Amino acid sequence given in first source; a 180 kD protein that contains multiple phosphorylated tyrosine residues after insulin stimulation; human and rat forms (hirs-1 and irs-1) are homologous Synonym: insulin receptor substrate-1-like protein, irs-1 protein, irs-1 gene product, hirs-1 protein, hirs-1 gene product, insulin receptor substrate 1, insulin receptor substrate-1 (05 Dec 1998) |
| enzyme-substrate complex | A noncovalent complex of two molecules; often referring to the enzyme-substrate complex in an enzyme-catalyzed reaction. Compare: central complex, Michaelis complex. Synonym: enzyme-substrate complex. (05 Mar 2000) |
| allogeneic inhibition | Inhibition or injury to allogeneic cells that occurs when lymphocytes are mixed and cultured with other cells of different genotypes in vitro. (05 Mar 2000) |
| macrophage inhibition factor | <cytokine> A group of lymphokines (including a 14 kD glycoprotein) produced by activated T lymphocytes that reduces macrophage mobility and probably increases macrophage macrophage adhesion. (18 Nov 1997) |
| macrophage migration inhibition test | A test which measures the presence of migration-inhibitory factor. Usually peritoneal macrophages are placed in a capillary tube in the presence or absence of supernatants from activated T-cells. If MIF is present, the migration of monocyte/macrophages is reduced. Synonym: macrophage migration inhibition test, migration inhibition test. (05 Mar 2000) |
| reactive inhibition | Tendency toward a lessened strength of response due to practice or activity. It is independent of the effect of reward and is a direct function of time interval since the last response and the number of preceding responses. (12 Dec 1998) |
| reciprocal inhibition | Contraction in a muscle is accompanied by a loss of tone or by relaxation in the antagonistic muscle. Synonym: reciprocal inhibition. (05 Mar 2000) |
| reflex inhibition | A situation in which sensory stimuli decrease reflex activity. (05 Mar 2000) |
| cell migration inhibition | Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated leukocytes or macrophages. Specific assays have been developed to estimate levels of migration-inhibitory factor, immune reactivity against tumour-associated antigens, and immunosuppressive effects of infectious microorganisms. (12 Dec 1998) |
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