| 영문 | exotoxin | 한글 | 외독소 |
|---|---|---|---|
| 설명 | 세균의 대사에 의해 생산되며 균체 밖으로 내보내는 단백질성 독소이며, 생체에 해롭게 작용한다. 대개는 열민감성이지만 열안정성인 것도 있다. 독소의 합성에 관한 유전자는 염색체성인 것, 파지, 또는 플라스미드에 의한 것이 있다. 독소는 그 작용메커니즘에 따라 신경독소, 창자독소, 세포독소로 분류되며 또한 마비독소, 구토독소, 설사독소, 용혈독소, 백혈구독소 등으로 불린다. 변형독소화에 의해 독성의 상실과 항원성의 유지가 가능하며 백신으로서 이용된다. 외독소의 주된 것은 콜레라독소, 독소원성 대장균의 열민감성 엔테로톡신, 열안정성 엔테로톡신, 장염 비브리오 용혈독, 포도알균 장관독소, 보툴리누스독소, 사슬알균 발적독소, 디프테리아독소, 백일해독소, 파상풍독소, 표피박탈 독소, TSS-1, 대장균 O-157의 배로독소(VT1, VT2)등이 있다. 내독소에 비해 독성이 높다. 외독소를 포르말린 처리로 무독화한 것을 톡소이드라고 하며, 이것은 주사를 해도 안전하며 독소에 대한 능동면역을 부여하는데 이용된다. |
||
| SPE | septic pulmonary edema; serum protein electrolytes; serum protein electrophoresis; streptococcal pyr... |
|---|---|
| SPE-C | streptococcal pyrogenic exotoxin type C |
| PE | Edinburgh Pharmacopoeia; pancreatic extract; paper electrophoresis; partial epilepsy; pelvic examina... |
| PEC | pelvic cramps; peritoneal exudate cell; pyrogenic exotoxin C |
| TSSE | toxic shock syndrome exotoxin |
| SPE | Streptococcal pyrogenic exotoxin |
|---|---|
| SPE A | Streptococcal pyrogenic exotoxin A |
| SPE B | Streptococcal pyrogenic exotoxin B |
| ETA | Exotoxin A |
| PE | Pseudomonas exotoxin |
| pyrogenic | <physiology> Fever inducing. Origin: Gr. Gennan = to produce (18 Nov 1997) |
|---|---|
| exotoxin | <protein> Toxin released from gram-positive and gram-negative bacteria as opposed to endotoxins that form part of the cell wall. Examples are cholera, pertussis and diphtheria toxins. Usually specific and highly toxic. (18 Nov 1997) |
| acute post-streptococcal glomerulonephritis | <nephrology> A disease of the kidneys that results in inflammation of the glomerulus (the portion of the kidney that filters the blood). Conditions which may cause glomerulonephritis include post-streptococcal disease (strep throat), lupus, syphilis, bacterial endocarditis, membranoproliferative glomerulonephritis, sepsis, vasculitis, Goodpasture's syndrome, typhoid fever, Henoch-Schonlein purpura, hepatitis or a viral infection (for example mumps, measles, mononucleosis). (27 Sep 1997) |
| group A streptococcal necrotizing fasciitis | A complication of infection with GAS (group A streptococci) in which the bacteria attacks and destroys muscle tissue. According to the CDC, 5-10% of people with severe GAS infection develop necrotizing fasciitis. Though the infection can be treated with antibiotics, the fatality rate is close to 30%. This complication often develops as a wound infection after surgery or injury. (05 Mar 2000) |
| streptococcal | Relating to or caused by any organism of the genus Streptococcus. (05 Mar 2000) |
| streptococcal fibrinolysin | <enzyme> Plasminogen activator released by Streptococcus pyogenes. Occurs in two forms, A and B. (18 Nov 1997) |
| streptococcal infections | Infections with bacteria of the genus streptococcus. (12 Dec 1998) |
| streptococcal lymphadenitis | A contagious bacterial disease of pigs caused by a group E streptococcus and characterised by the formation of abscesses in the cervical and/or cephalic lymph nodes. (05 Mar 2000) |
| streptococcal nuclease | <enzyme> From streptococcus haemolyticus; degrades RNA and DNA producing oligonucleotides terminating in 5'-phosphate Registry number: EC 3.1.30.- (26 Jun 1999) |
| streptococcal pneumonia | Pneumonia due to Streptococcus pyogenes. (05 Mar 2000) |
| streptococcal toxins | Group of haemolytic exotoxins released by Streptococci. _ haemolysin: 26-39 Kd (four types), forms ring like structures in membranes (see Streptolysin O). Lipid target unclear. _ haemolysin: a hot cold haemolysin with sphingomyelinase C activity. _ haemolysin: complex of two proteins (29 and 26 kD) that act synergistically, rabbit erythrocytes particularly sensitive. _ toxin: heat stable peptide (5 kD) with high proportion of hydrophobic amino acids. Seems to act in a detergent like manner (c.f. Subtilysin), but may form hydrophilic transmembrane pores by cooperative interaction with other _ toxin molecules. Leucocidin (Panton Valentine leucocidin): two components f (fast migration on CM cellulose column: 32 kD) and s (slow: 38 kD). Mode of action contentious. See: Streptococcus, streptolysins O and S, erythrogenic toxin. (18 Nov 1997) |
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|