| ¿µ¹® | steroid | ÇÑ±Û | ½ºÅ×·ÎÀ̵å |
|---|---|---|---|
| ¼³¸í | Hydrogenated cyclopentanoperhydrophenanthrene ring systemÀ¸·Î ±¸¼ºµÈ ºÐÀÚ. »ýü³»¿¡¼ Áß¿äÇÑ ½ºÅ×·ÎÀ̵å´Â ºÎ½Å°ÑÁú¿¡¼ »ý¼ºµÇ´Â ½ºÅ×·ÎÀ̵å È£¸£¸óÀÌ¸ç ´ç´ë»ç¿¡ °ü¿©ÇÏ´Â ±Û·çÄÚÄÚ¸£Æ¼ÄÚÀ̵å(glucocorticoid), ¿°·ù´ë»ç(ÀÎü³» Á¸ÀçÇÏ´Â ¿°ºÐ¼ººÐ(NaCl, KCl, NaOH µî)À» Á¶ÀýÇÏ´Â ´ë»ç)¿¡ °ü¿©ÇÏ´Â ±¤¹°ÄÚ¸£Æ¼ÄÚÀ̵å(mineralocorticoid), ¼ºÈ£¸£¸ó(ÀÎüÀÇ ¼º¹ß´Þ¿¡ °ü¿©)ÀÇ ¼¼ °¡ÁöÀÌ´Ù. ½ºÅ×·ÎÀ̵å È£¸£¸óÀº ºÎ½ÅÇÇÁú¿¡¼ ÄÝ·¹½ºÅ×·ÑÀ» Àç·á·Î ÇÏ¿© º¹ÀâÇÑ ÇÕ¼º´Ü°è¸¦ °ÅÃÄ ÇÕ¼ºµÈ´Ù. ±Û·çÄÚÄÚ¸£Æ¼ÄÚÀ̵å´Â ³úÇϼöü¿¡¼ ºÐºñµÇ´Â ºÎ½Å°ÑÁúÀÚ±Ø È£¸£¸ó(ACTH)¿¡ ÀÇÇØ »ý¼º°ú ºÐºñ°¡ ÀÌ·ç¾îÁö³ª ±¤¹°ÄÚ¸£Æ¼ÄÚÀ̵å´Â ·¹´Ñ-¾ÈÁö¿ÀÅٽŰè(½ÅÀå¿¡¼ ÀÎü³» ¿°ºÐÀÌ ºÎÁ·½Ã ·¹´ÑÀÌ ºÐºñµÇ°í, ÀÌ ÀÚ±ØÀº ºÎ½ÅÀ¸·Î ÀüÇØÁ® ±¤¹°ÄÚ¸£Æ¼ÄÚÀ̵åÀÎ ¾ÈÁö¿ÀÅÙ½ÅÀ» ºÐºñÇÏ°Ô µÊ)ÀÇ Àڱؿ¡ ÀÇÇØ ºÐºñµÈ´Ù. ±Û·çÄÚÄÚ¸£Æ¼ÄÚÀ̵å´Â transcortin°ú °áÇÕÇÏ¿© ¿î¹ÝµÇ¸ç ¹Ý°¨±â´Â Çѽð£ Á¤µµÀ̳ª ¿°·ùÄÚ¸£Æ¼ÄÚÀ̵å´Â ´ëºÎºÐÀÌ ´Ü¹éÁú°ú °áÇÕÇÏÁö ¾Ê°í À¯¸®ÇüÀ¸·Î ³²¾ÆÀÖ¾î ¹Ý°¨±â´Â 20ºÐ¿¡ ºÒ°úÇÏ´Ù. À̵éÀÌ °£¿¡ µµ´ÞÇϸé glucuronic acid¿¡ °áÇÕÇÏ¿© ¹è¼³µÈ´Ù. |
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| ¿µ¹® | solid tumor | ÇÑ±Û | °íÇüÁ¾¾ç |
|---|---|---|---|
| ¼³¸í | ¼¼Æ÷·Î ²Ë Âù Á¾¾çÀ» ¸»ÇÔ. ¹éÇ÷º´ µîÀÇ Ç÷¾×¾Ï°ú °°ÀÌ ÇüŸ¦ ÃëÇÏÁö ¾Ê°í ¾×üÀÎ »óÅÂÀÇ ¾Ï°ú ´ëÁ¶µÇ´Â ¿ë¾î·Î¼ ´Ü´ÜÇÑ µ¢¾î¸®·Î ±¸¼ºµÈ ¾Ç¼ºÁ¾¾çÀÌ´Ù. ´ëºÎºÐÀÇ Á¾¾çÀÌ ÀÌ¿¡ ÇØ´çÇÑ´Ù. ƯÈ÷ Ç¥ÇÇÁ¶Á÷¿¡¼ ±â¿øÇÑ Á¾¾çÀ» ¸»ÇÑ´Ù. |
||
| ¿µ¹® | ulcerating tumor | ÇÑ±Û | ±Ë¾ç¼º Á¾¾ç |
|---|---|---|---|
| ¼³¸í | Á¾¾çÀÇ Ç¥¸é¿¡ ±Ë¾çÀÌ ¹ß»ýÇÏ´Â °Í. ´ë°³, ¸Å¿ì »¡¸® ÀÚ¶ó´Â Á¾¾ç¿¡¼ Ç÷·ù °ø±ÞÀÌ Á¾¾ç¼¼Æ÷ÀÇ ÀÚ¶ó´Â ¼Óµµ¸¦ °¨´çÇÏÁö ¸øÇØ Á¾¾çÁ߽ɺΠÁ¶Á÷ÀÌ ±«»ç¿¡ ºüÁ® ±Ë¾çÀ» Çü¼ºÇÏ´Â °æ¿ì°¡ ¸¹´Ù. À°¾ÈÀ¸·Î º¸¸é »¡°²°í, ¿À̳ª¸ç, ÁöÀúºÐÇØ º¸ÀδÙ. |
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| ¿µ¹® | brain tumor | ÇÑ±Û | ³úÁ¾¾ç |
|---|---|---|---|
| ¼³¸í | ³úÁ¾¾çÀ̶õ ³ú¿Í ³úÁ¶Á÷¿¡¼ »ý±ä Á¾¾çÀ» ÁöĪÇÏ´Â ¸»ÀÌ´Ù. ±×·¯³ª ´ë°³ ³ÐÀº Àǹ̷Π»ç¿ëÇÒ °æ¿ì¿¡´Â ¸Ó¸®»À¼ÓÀÇ °ø°£ÀÎ µÎ°³°¼Ó¿¡ »ý±â´Â ¸ðµç Á¾¾çÀ» À̸£´Â ¸»·Î »ç¿ëµÈ´Ù. ³úÁ¾¾çÀº ÇÑÁ¤µÈ °ø°£ÀÎ µÎ°³°¿¡¼ ¹ß»ýÇϹǷΠÁ¾¾çÀÌ ±×´ÙÁö Å©Áö ¾Ê¾Æµµ Á¤»óÀûÀÎ Á¶Á÷À» ¾Ð¹ÚÇÏ°Ô µÇ°í, µÎ°³°³»ÀÇ ¾Ð·ÂÀ» ³ôÀδÙ. ÀÌ·± Ư¡¿¡ ÀÇÇØ¼ ³úÁ¾¾çÀÇ Áõ»óÀº ´Ù¸¥ Á¾¾ç°ú ´Þ¸®, Á¾¾ç ±× ÀÚüÀÇ Áõ»óº¸´Ùµµ µÎ°³³»¾Ð»ó½Â°ú Á¤»óÁ¶Á÷ÀÇ ¾Ð¹Ú¿¡ ÀÇÇÑ Áõ»óÀÌ ¸¹´Ù. µÎ°³³»¾Ð(³ú¾Ð)ÀÇ »ó½Â¿¡ ÀÇÇÑ Áõ»óÀ¸·Î´Â µÎÅë, ±¸ÅäµîÀÌ ÀÖÀ¸¸ç, Áö¼ÓÀûÀÎ ³ú¾Ð»ó½Â¿¡ ÀÇÇØ¼ À¯µÎºÎÁ¾(papilledema)ÀÌ °üÂûµÇ±âµµ ÇÑ´Ù. ±×¸®°í Á¤»óÀûÀÎ ³úÁ¶Á÷ÀÇ ¾Ð¹Ú°ú Á¾¾çÀÌ »ý±ä ºÎÀ§ÀÇ ±â´ÉÀÇ °áÇÕ¿¡ ³úÀÇ ±× ºÎºÐ¿¡ ÇØ´çÇÏ´Â ±â´ÉÀÇ »ó½ÇÀ» º¸°ÔµÈ´Ù. |
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| ¿µ¹® | epithelial tumor | ÇÑ±Û | »óÇǼºÁ¾¾ç |
|---|---|---|---|
| ¼³¸í | Á¤»ó »ç¶÷ÀÇ Á¶Á÷Àº üǥ¸éÀ» µ¤´Â ¿ªÇÒÀ» ÇÏ´Â Á¶Á÷°ú, ÁÖ·Î ¹ß»ý±âÀÇ Á߹迱¿¡¼ ºÐÈÇÑ °£¿±Á¶Á÷¿¡¼ À¯·¡ÇÏ´Â °áÇÕÁ¶Á÷, »À, ¿¬°ñ, Áö¹æ, ±ÙÀ°, Ç÷°ü µîÀÇ Á¶Á÷ÀÇ µÎ °èÅëÀ¸·Î ³ª´ ¼ö ÀÖ´Ù. ÀüÀÚ¸¦ »óÇǼº Á¶Á÷, ÈÄÀÚ¸¦ ºñ»óÇǼº Á¶Á÷À̶ó ÇÏ¸ç ±× °¢°¢À» ±¸¼ºÇÏ´Â ¼¼Æ÷¸¦ »óÇǼº ¼¼Æ÷, ºñ»óÇǼ¼Æ÷¶ó ÃÑĪÇÑ´Ù. »óÇǼº ¼¼Æ÷¿¡¼ ±â¿øÇÏ´Â Á¾¾çÀÌ »óÇǼº Á¾¾çÀ̸ç, ±ÙóÀÇ Á¶Á÷À¸·Î ħÅõ³ª Ç÷·ù, ¸²ÇÁÀÇ Á¶Á÷À» Ÿ°í ¿ø°Å¸®ÀÇ Àå±â·Î À̵¿ÇÏÁö ¾Ê´Â ¾ç¼ºÁ¾¾ç¿¡´Â ¼±Á¾, À¯µÎÁ¾ µîÀÌ ÀÖ°í ¾ç¼º°ú ¹Ý´ë·Î ±ÙóÀÇ Á¶Á÷À¸·Î ħÅõ, ¿ø°ÝÀå±â·Î ÀüÀÌÇÏ´Â ¾Ç¼ºÁ¾¾çÀ» ¸ðµÎ ÅëĪÇÏ¿© ¾ÏÁ¾(carcinoma)À̶ó°í ÇÑ´Ù. |
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| GCT | general care and treatment; germ-cell tumor; giant cell thyroiditis; giant cell tumor |
|---|---|
| AFP | Alpha(¥á) Feto-Protein [HP 1826, 1858, 1859, 2265] ; Oncofetal Antigens &nbs... |
| CT | calcitonin; calf testis; cardiac tamponade; cardiothoracic [ratio]; carotid tracing; carpal tunnel; ... |
| MC | mass casualties; mast cell; Master of Surgery [Lat. Magister Chirurgiae]; maximum concentration; Med... |
| MEN | Multiple Endocrine Neoplasia ; AD Trait 1. MEN Type I(= Wermer Syndro... |
| 3 beta-HSD | 3 beta hydroxy steroid dehydrogenase |
|---|---|
| 3 beta-HSD | 3 beta-hydroxy-steroid dehydrogenase/delta 5-delta 4 isomerase |
| AAS | Anabolic androgenic steroid |
| NSAID | Non Steroid Anti-Inflammatory Drugs |
| SBP | Steroid Binding Protein |
| tumor | 1. <oncology> An abnormal mass of tissue that results from excessive cell division that is uncontrolled and progressive, also called a neoplasm. Tumours perform no useful body function. They may be either benign (not cancerous) or malignant. 2. Swelling, one of the cardinal signs of inflammations, morbid enlargement. Origin: L. Tumere = to swell (12 May 1997) |
|---|---|
| tumor marker | <investigation, oncology> A substance in the body that usually indicates the presence of cancer. These markers are usually specific to certain types of cancer and are usually found in the blood or other tissue samples. Examples are alphafetoprotein (AFP), human chorionic gonadotropin, and lactate dehydrogenase (LDH). They may be indicators of tumour stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids. (18 Jul 2002) |
| tumor necrosis factor | <cytokine> Originally described as a tumour inhibiting factor in the blood of animals exposed to bacterial lipopolysaccharide or Bacille Calmette-Guerin. Preferentially kills tumour cells in vivo and in vitro, causes necrosis of certain transplanted tumours in mice and inhibits experimental metastases. Human Tumour Necrosis factor alpha is a protein of 157 amino acids and has a wide range of pro inflammatory actions. Usually considered a cytokine. Synonym: cachectin. Acronym: TNF (13 Nov 1997) |
| anabolic steroid | <endocrinology> A type of steroid hormone that stimulates the synthesis of protein. Anabolic steroids are compounds which stimulate the body into anabolism. This process involves the building of complex compounds from smaller simpler ones (for example proteins are built from amino acids). This process requires energy. (13 Nov 1997) |
| receptors, steroid | Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behaviour of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes. (12 Dec 1998) |
| gonadal steroid-binding globulin | A protein that transports 65% of the testosterone in plasma. Synonym: sex steroid-binding globulin. (05 Mar 2000) |
| saturated steroid 6 alpha-hydroxylase | <enzyme> Acts on 5 alpha-androstane-3 beta,17 beta-diol and 5 alpha-pregnan-3 beta-ol-20-one; does not require cytochrome p-450 Registry number: EC 1.14.99.- Synonym: sat steroid 6alpha-hydroxylase (26 Jun 1999) |
| sex steroid-binding globulin | A protein that transports 65% of the testosterone in plasma. Synonym: sex steroid-binding globulin. (05 Mar 2000) |
| steroid | A group name for lipids that contain a hydrogenated cyclopentanoperhydrophenanthrene ring system. Some of the substances included in this group are progesterone, adrenocortical hormones, the gonadal hormones, cardiac aglycones, bile acids, sterols (such as cholesterol), toad poisons, saponins and some of the carcinogenic hydrocarbons. (18 Nov 1997) |
| steroid 11-alpha-hydroxylase | <enzyme> Converts 11-deoxycortisol to 11-alpha cortisol (the 11-alpha isomer of hydrocortisone) Registry number: EC 1.14.99.- (26 Jun 1999) |
| steroid 11 beta-monooxygenase | <enzyme> A steroid hydroxylase system found in adrenal tissues. It catalyses the 11-hydroxylation of steroids in the presence of molecular oxygen and consists of an NADPH-specific flavoprotein, a non-haem iron protein, and cytochrome p-450. Its deficiency is a cause of congenital adrenal hyperplasia (adrenal hyperplasia, congenital). Chemical name: Steroid, reduced-adrenal-ferredoxin:oxygen oxidoreductase (11 beta-hydroxylating) Registry number: EC 1.14.15.4 (12 Dec 1998) |
| steroid 12-monooxygenase | <enzyme> A steroid hydroxylase found in liver microsomes. It catalyses the 12-hydroxylation of steroids in the presence of NADPH, cytochrome p-450, and molecular oxygen. It is an important enzyme in the synthesis of cholic acid from cholesterol in the liver. Chemical name: Steroid, hydrogen-donor:oxygen oxidoreductase (12-alpha-hydroxylating) Registry number: EC 1.14.99.- (12 Dec 1998) |
| steroid 14-alpha-hydroxylase | <enzyme> From induced vegetative cell cultures of mucor piriformis; hydroxylates progesterone to 14-alpha-hydroxyprogesterone in the presence of NADPH and oxygen Registry number: EC 1.14.13.- Synonym: progesterone 14-alpha-hydroxylase (26 Jun 1999) |
| steroid 15-beta-hydroxylase | <enzyme> Contains p-450 and ferredoxin; from bacillus megaterium Registry number: EC 1.14.99.- Synonym: cytochrome p-450 15 beta-hydroxylase, p-450 (15-beta), steroid-15 beta-monooxygenase, cytochrome p-450meg, cytochrome p4502c12, cyp2c12 protein (26 Jun 1999) |
| steroid 17 alpha-monooxygenase | <enzyme> A steroid hydroxylase system found in the microsomal membrane of the steroid-hormone producing tissues. It catalyses the 17-hydroxylation of steroids, such as progesterone or pregnenolone in the presence of NADPH and molecular oxygen. This is an important step in the biosynthesis of steroid hormones. Chemical name: Steroid, hydrogen-donor:oxygen oxidoreductase (17 alpha-hydroxylating) Registry number: EC 1.14.99.9 (12 Dec 1998) |
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