| ESE | Exonic splicing enhancer |
|---|---|
| NRS | negative regulator of splicing |
| gap junctions | Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of connexins, the family of proteins which form the junctions. (12 Dec 1998) |
|---|---|
| impermeable cell junctions | <cell biology> Specialised intercellular junction in which the two plasma membranes are separated by only 1-2nm. Found near the apical surface of cells in simple epithelia, forms a sealing gasket around the cell. Prevents fluid moving through the intercellular gap and the lateral diffusion of intrinsic membrane proteins between apical and baso lateral domains of the plasma membrane. (18 Nov 1997) |
| intercellular junctions | Direct contact of a cell with a neighboring cell. most such junctions are too small to be resolved by light microscopy, but they can be visualised by conventional or freeze-fracture electron microscopy, both of which show that the interacting cell membrane and often the underlying cytoplasm and the intervening extracellular space are highly specialised in these regions. (12 Dec 1998) |
| tight junctions | Cell-cell junctions that seal adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. (alberts et al., molecular biology of the cell, 2nd ed, pg-22) (12 Dec 1998) |
| junctions | See: adherens junction, desmosome, gap junction, zonula occludens. (18 Nov 1997) |
| acceptor splicing site | Boundary between the right end of an intron and the left end of the adjacent exon. Synonym: acceptor splicing site. (05 Mar 2000) |
| alternative mRNA splicing | Splicing different exons in or out of messenger RNA to form different mRNA transcripts. (09 Oct 1997) |
| alternative splicing | A process whereby multiple protein isoforms are generated from a single gene. Alternative splicing involves the splicing together of nonconsecutive exons during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form messenger RNA. The alternative forms produce proteins in which one part is common while the other part is different. (12 Dec 1998) |
| gene splicing | A procedure by which one DNA molecule or fragment can be attached to another. (14 Nov 1997) |
| right splicing junction | Boundary between the right end of an intron and the left end of the adjacent exon. Synonym: acceptor splicing site. (05 Mar 2000) |
| RNA splicing | <molecular biology> The removal of introns from primary RNA transcripts. (23 Aug 1998) |
| RNA splicing pattern | <molecular biology> The combination of DNA sequences copied from a gene by messenger RNA. The mRNAs transcribed from a single gene may splice together different parts of the sequence of the gene. (23 Aug 1998) |
| protein splicing | Excision of in-frame internal protein sequences (inteins) of a precursor protein, coupled with ligation of the flanking sequences (exteins). Protein splicing is an autocatalytic reaction and results in the production of two proteins from a single primary translation product: the intein and the mature protein. (12 Dec 1998) |
| self splicing | <molecular biology> Self catalysed removal of group 5 introns, mediated by six paired conserved regions. (18 Nov 1997) |
| splicing | <molecular biology> The process by which introns are removed from hnRNA to produce mature messenger RNA that contains only exons. Alternative splicing seems to occur in many proteins and by alternative exon usage a set of related proteins can be generated from one gene, often in a tissue or developmental stage specific manner. (18 Nov 1997) |
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