| 영문 | hemoglobin | 한글 | 혈색소 |
|---|---|---|---|
| 설명 | 척추동물의 적혈구 속에 다량으로 들어있는 색소단백질. 철을 품는 포르피린 고리와 단백질의 일종(글로빈)으로 되어 있다. 철(Fe)에는 산소와 가역적으로 결합하는 능력이 있어, 생체 내에서는 산소를 운반하는 일을 한다. 혈색소 한 분자는 네 개의 폴리펩티드 사슬로 되어 있고, 각각의 폴리펩티드 사슬에는 한 개씩의 헴이 함유되어 있다. 따라서 혈색소 한 분자에는 철원자가 네 개 함유되고, 철원자 한 개에 대해 한 분자씩의 산소가 결합하므로, 혈색소 한 분자에는 산소 4분자가 결합한다. 혈색소는 산소압이 높은 허파나 아가미에서는 산소와 결합하고, 산소압이 낮은 조직에 이르면 산소를 유리한다. 더욱이 산소의 방출은 pH가 낮아짐에 따라 촉진되므로, 이산화탄소가 많고 pH가 낮은 말초조직에서는 산소를 보다 유리하기 쉽게 된다. 이산화탄소는 혈장 속에 녹아 허파에 운반되어 허파호흡으로 체외에 방출되면 pH는 다시 원상태로 돌아가고 혈색소는 다시 산소와 결합한다. 분자량 약 6,500의 색소단백질로 혈액 속에서의 함유량은 혈액 100 mL중의 그램수로 나타낸다. 정상치는 남자 16g/dL(14~18g/dL), 여자 14g/dL (12~16g/dL)이다. |
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| HbS | hemoglobin S, sickle-cell hemoglobin |
|---|---|
| S-D | sickle-cell hemoglobin D; suicide-depression |
| SF | Sabin-Feldman [test]; safety factor; salt-free; scarlet fever; screen film; seminal fluid; serosal f... |
| HbA | hemoglobin A, adult hemoglobin |
| HbF | fetal hemoglobin, hemoglobin F |
| PSR | Proliferative sickle retinopathy |
|---|---|
| SCD | Sickle Cell Disease |
| SCA | Sickle cell anaemia |
| SCT | Sickle cell trait |
| DCLHb | Diaspirin Cross-Linked Hemoglobin |
| hemoglobin | <cell biology, haematology> Four subunit globular oxygen carrying protein of the erythrocytes of vertebrates and some invertebrates. It is a conjugated protein containing four haem groups and globin. There are two alpha and two beta chains (very similar to myoglobin) in adult humans, the haem moiety (an iron containing substituted porphyrin) is firmly held in a nonpolar crevice in each peptide chain. There are four globin polypeptide chains, designated alpha, beta, gamma, delta in the adult. Each is composed of several hundred amino acids. (08 Mar 2000) |
|---|---|
| anaemia, sickle cell | A disease characterised by chronic haemolytic anaemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for haemoglobin s. (12 Dec 1998) |
| haemoglobin, sickle | An abnormal haemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anaemia. (12 Dec 1998) |
| sickle | 1. A reaping instrument consisting of a steel blade curved into the form of a hook, and having a handle fitted on a tang. The sickle has one side of the blade notched, so as always to sharpen with a serrated edge. Cf. Reaping hook, under Reap. "When corn has once felt the sickle, it has no more benefit from the sunshine." (Shak) 2. <astronomy> A group of stars in the constellation Leo. <botany> Sickle pod, a kind of rock cress (Arabis Canadensis) having very long curved pods. Origin: OE. Sikel, AS. Sicol; akin to D. Sikkel, G. Sichel, OHG. Sihhila, Dan. Segel, segl, L. Secula, fr. Secare to cut; or perhaps from L. Secula. See Saw a cutting instrument. Source: Websters Dictionary (01 Mar 1998) |
| sickle cell | <haematology, pathology> An erythrocyte that changes from the normal discoid shape to a sickled shape when the oxygen tension is low. The pesence of these cells indicates that the patient is homozygotes for the allele that codes for haemoglobin S and that the patient has sickle cell anaemia. (18 Nov 1997) |
| sickle cell anaemia | <haematology> Disease common in races of people from areas in which malaria is endemic. The cause is a point mutation in the allele that codes for the beta chain of haemoglobin with a substitution of (valine for glutamic acid at position 6. The defective haemoglobin (HbS) crystallizes readily at low oxygen tension. In consequence, erythrocytes from homozygotes change from the normal discoid shape to a sickled shape when the oxygen tension is low and these sickled cells become trapped in capillaries or damaged in transit, leading to severe anaemia. In heterozygotes, the disadvantages of the abnormal haemoglobin are apparently outweighed by increased resistance to Plasmodium falciparum malaria, probably because parasitised cells tend to sickle and are then removed from circulation. Symptoms include joint pain, acute abdominal pain, and ulcerations of the lower extremities. Origin: Gr. Haima = blood (18 Nov 1997) |
| sickle cell anaemia: bone manifestations | <radiology> 8-13% of blacks carry sickling factor, symptoms: chronic ulcers, pain crises, many infections, priapism X-ray findings: deossification due to marrow hyperplasia, decreased bone density in skull with widened diploe, H-shaped vertebrae or fish vertebrae, rib notching, thrombosis and infarction, avascular necrosis, especially femoral head, periosteal treatmentn (bone within bone), secondary osteomyelitis, Staph. Aureus greater than Salmonella, dactylitis = hand foot syndrome, growth effects, bone shortening secondary to diminished blood supply, death less than 40y (12 Dec 1998) |
| sickle cell C disease | A disease resulting from abnormal sickle-shaped erythrocytes (containing haemoglobin C and S) which appear in response to a lowering of the partial pressure of oxygen; characterised by anaemia, crises due to haemolysis or vascular occlusion, chronic leg ulcers and bone deformities, and infarcts of bone or of the spleen. (05 Mar 2000) |
| sickle cell crisis | <haematology> Disease common in races of people from areas in which malaria is endemic. The cause is a point mutation in the allele that codes for the beta chain of haemoglobin with a substitution of (valine for glutamic acid at position 6. The defective haemoglobin (HbS) crystallizes readily at low oxygen tension. In consequence, erythrocytes from homozygotes change from the normal discoid shape to a sickled shape when the oxygen tension is low and these sickled cells become trapped in capillaries or damaged in transit, leading to severe anaemia. In heterozygotes, the disadvantages of the abnormal haemoglobin are apparently outweighed by increased resistance to Plasmodium falciparum malaria, probably because parasitised cells tend to sickle and are then removed from circulation. Symptoms include joint pain, acute abdominal pain, and ulcerations of the lower extremities. Origin: Gr. Haima = blood (18 Nov 1997) |
| sickle cell dactylitis | <syndrome> Recurrent painful swelling of the hands and feet occurring in infants and young children with sickle cell anaemia. Synonym: sickle cell dactylitis. (05 Mar 2000) |
| sickle cell disease | <haematology> Disease common in races of people from areas in which malaria is endemic. The cause is a point mutation in the allele that codes for the beta chain of haemoglobin with a substitution of (valine for glutamic acid at position 6. The defective haemoglobin (HbS) crystallizes readily at low oxygen tension. In consequence, erythrocytes from homozygotes change from the normal discoid shape to a sickled shape when the oxygen tension is low and these sickled cells become trapped in capillaries or damaged in transit, leading to severe anaemia. In heterozygotes, the disadvantages of the abnormal haemoglobin are apparently outweighed by increased resistance to Plasmodium falciparum malaria, probably because parasitised cells tend to sickle and are then removed from circulation. Symptoms include joint pain, acute abdominal pain, and ulcerations of the lower extremities. Origin: Gr. Haima = blood (18 Nov 1997) |
| sickle cell haemoglobin | <haematology> Haemoglobin S is an abnormal version of the protein haemoglobin. The sixth amino acid of the normal beta chain, glutamic acid, is replaced by valine with gluconic acid. This mutation causes the red blood cell to take on a sickle shape, and is the cause of the sickle cell trait condition (when the individual is heterozygous for this mutant haemoglobin) and the disease of sickle cell anaemia (when the individual is homozygous for this mutant haemoglobin). (09 Oct 1997) |
| sickle cell prep | <haematology, investigation> A test which looks at red blood cells under the microscope to detect sickle cells after an agent which lowers the oxygen content of the sample is added. A positive test is result is determined by the presence of sickle cells. Abnormal results indicate sickle cell anaemia or sickle cell trait. (27 Sep 1997) |
| sickle cell retinopathy | A condition marked by dilation and tortuosity of retinal veins, and by microaneurysms and retinal haemorrhages; advanced stages may show neovascularization, vitreous haemorrhage, or retinal detachment. (05 Mar 2000) |
| sickle cell test | <investigation> A test which looks at red blood cells under the microscope to detect sickle cells after an agent which lowers the oxygen content of the sample is added. A positive test is result is determined by the presence of sickle cells. Abnormal results indicate sickle cell anaemia or sickle cell trait. (27 Sep 1997) |
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|