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RB radiation burn; rating board; rebreathing; reticulate body; retinoblastoma; right bronchus; right bu...
Rb retinoblastoma; rubidium
RBBP retinoblastoma binding protein
RBL rat basophilic leukemia; Reid baseline; retinoblastoma-like
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RCE 3'-retinoblastoma control element
RB Retinoblastoma
RB-1 Retinoblastoma
RB retinoblastoma susceptibility
CancerWEB ¿µ¿µ ÀÇÇлçÀü ¸ÂÃã °Ë»ö °á°ú : 2 ÆäÀÌÁö: 1
retinoblastoma <oncology, tumour> Malignant tumour of the retina, usually arising in the inner nuclear layer of the neural retina.
Retinoblastoma is unusual in being caused by an autosomal dominant mutation in some cases (about 6%), in which case it may be bilateral.
The gene product of the retinoblastoma gene is a tumour suppressor that interacts with transcription factors such as E2F to block transcription of growth regulating genes. The Rb gene plays a role in normal development, not just that of the retina.
Inheritance: autosomal dominant.
(03 Jul 1999)
retinoblastoma protein <molecular biology, protein> Product of the retinoblastoma tumour suppressor gene.
It is a nuclear phosphoprotein hypothesised to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus e1a protein, the sv40 t antigen, and the human papilloma virus e7 protein.
(03 Jul 1999)
CancerWEB ¿µ¿µ ÀÇÇлçÀü À¯»ç °Ë»ö °á°ú : 1 ÆäÀÌÁö: 1
genes, retinoblastoma Tumour suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging from 104 kD to 115 kD. One copy of the wild-type rb gene is necessary for normal retinal development. Loss or inactivation of both alleles at this locus results in retinoblastoma.
(12 Dec 1998)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 4 ÆäÀÌÁö: 1
  • Retinoblastoma - »õâ A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
    Synonyms : Familial Retinoblastoma, Hereditary Retinoblastoma, Sporadic Retinoblastoma, Familial Retinoblastomas, Glioblastomas, Retinal, Gliomas, Retinal, Hereditary Retinoblastomas, Neuroblastomas, Retinal, Retinal Glioblastoma, Retinal Glioblastomas, Retinal Glioma
  • Retinoblastoma Protein - »õâ Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.
    Synonyms : Rb Gene Product, Rb1 Gene Product, Retinoblastoma Nuclear Phosphoprotein p105 Rb, p105 Rb Protein
  • Retinoblastoma-Like Protein p107 - »õâ A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. It contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.
    Synonyms : RBL1 Protein, Retinoblastoma Like Protein p107, p107 Tumor Suppressor Protein, Retinoblastoma Like Protein 1, p107, Retinoblastoma-Like Protein
  • Retinoblastoma-Like Protein p130 - »õâ A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. RBL2 contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and E2F5 TRANSCRIPTION FACTOR. RBL2 also interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.
    Synonyms : RBL2 Protein, Retinoblastoma Like Protein p130, Retinoblastoma Like Protein 2, p130, Retinoblastoma-Like Protein
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retinoblastoma malignant ocular tumor of retinal cells; usually occurs before the third year of life; composed of primitive small round retinal cells
Ãâó: wordnet.princeton.edu/perl/webwn
retinoblastoma (ret
Ãâó: www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspz...
retinoblastoma An eye cancer that most often occurs in children younger than 5 years. It occurs in hereditary and nonhereditary (sporadic) forms.
Ãâó: www.stjude.org/glossary
retinoblastomas Tumors of the eye.
Ãâó: www.epa.gov/envirohealth/children/background/gloss...
retinoblastoma An eye cancer caused by the loss of a pair of tumor-suppressor genes; the inherited form typically appears in childhood, since one gene is missing from the time of birth.
Ãâó: aspin.asu.edu/geneinfo/glos-r.htm
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retinoblastoma malignant ocular tumor of retinal cells
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