| PRS | Personality Rating Scale; Pierre Robin syndrome; plasma renin substrate; proctorectosigmoidoscopy |
|---|---|
| ASP | abnormal spinal posture; acute symmetric polyarthritis; African swine pox; aged substrate plasma; al... |
| BSS | Bachelor of Sanitary Science; balanced salt solution; Bernard-Soulier syndrome; black silk suture; b... |
| DS | dead air space; dead space; deep sedative; deep sleep; defined substrate; dehydroepiandrosterone sul... |
| ES | ejection sound; elastic stocking; electrical stimulus, electrical stimulation; electroshock; emergen... |
| PRS | Plasma Renin Substrate |
|---|---|
| RS | Renin substrate |
| CAS | Crk-associated substrate |
| IRS | Insulin Receptor Substrate |
| IRS-2 | Insulin receptor substrate 2 |
zymologist
| renin | <enzyme> An enzyme of the hydrolase class that catalyses cleavage of the leucine leucine bond in angiotensin to generate angiotensin. 1. The enzyme is synthesised as inactive prorenin in the kidney and released into the blood in the active form in response to various metabolic stimuli. Not to be confused with rennin (chymosin). (25 Jun 1999) |
|---|---|
| renin-angiotensin-aldosterone system | The hormones, renin, angiotensin, and aldosterone work together to regulate blood pressure. A sustained fall in blood pressure causes the kidney to release renin. This is converted to angiotensin in the circulation. Angiotensin then raises blood pressure directly by arteriolar constriction and stimulates adrenal gland to produce aldosterone which promotes sodium and water retention by kidney, such that blood volume and blood pressure increase. (05 Mar 2000) |
| renin-angiotensin system | <physiology> A system consisting of renin, angiotensin-converting enzyme, and angiotensin II. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming angiotensin I. The converting enzyme contained in the lung acts on angiotensin I in the plasma converting it to angiotensin II, the most powerful directly pressor substance known. It causes contraction of the arteriolar smooth muscle and has other indirect actions mediated through the adrenal cortex. (25 Jun 1999) |
| plasma renin activity | The estimation of renin in plasma by measuring the rate of formation of angiotensin I or II. (05 Mar 2000) |
| substrate | <chemistry> A substance upon which an enzyme acts. Origin: L. Stratum = layer (18 Nov 1997) |
| substrate cycle | <biochemistry> Any seqence of enzyme catalysed reactions in which the forward and reverse processes (catalysed by different enzymes) are consititutively active. Frequently used to describe the cycle of phosphorylation and dephosphorylation of phosphatidyl inositol derivatives in cell membranes. (05 Jan 1998) |
| substrate cycling | A set of opposing, nonequilibrium reactions catalyzed by different enzymes which act simultaneously, with at least one of the reactions driven by ATP hydrolysis. The results of the cycle are that ATP energy is depleted, heat is produced and no net substrate-to-product conversion is achieved. Examples of substrate cycling are cycling of gluconeogenesis and glycolysis pathways and cycling of the triglycerides and fatty acid pathways. Rates of substrate cycling may be increased many-fold in association with hypermetabolic states resulting from severe burns, cold exposure, hyperthyroidism, or acute exercise. (12 Dec 1998) |
| substrate inhibition | Inhibition of an enzyme activity by a substrate of the reaction catalyzed by that enzyme; often, this type of inhibition occurs at elevated substrate levels in which the substrate is binding to a second, non-active site on the enzyme. (05 Mar 2000) |
| substrate-level phosphorylation | Synthesis of high-energy phosphate bonds through reaction of inorganic phosphate with an activated (usually) organic substrate. (09 Oct 1997) |
| substrate specificity | A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts. (12 Dec 1998) |
| suicide substrate | A competitive inhibitor that is converted to an irreversible inhibitor at the active site of the enzyme. Synonym: mechanism-based inhibitor. (05 Mar 2000) |
| insulin receptor substrate-1 protein | <chemical> Amino acid sequence given in first source; a 180 kD protein that contains multiple phosphorylated tyrosine residues after insulin stimulation; human and rat forms (hirs-1 and irs-1) are homologous Synonym: insulin receptor substrate-1-like protein, irs-1 protein, irs-1 gene product, hirs-1 protein, hirs-1 gene product, insulin receptor substrate 1, insulin receptor substrate-1 (05 Dec 1998) |
| enzyme-substrate complex | A noncovalent complex of two molecules; often referring to the enzyme-substrate complex in an enzyme-catalyzed reaction. Compare: central complex, Michaelis complex. Synonym: enzyme-substrate complex. (05 Mar 2000) |
| renin substrate |
Angiotensinogen.
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