| LAD | lactic acid dehydrogenase; left anterior descending [artery]; left axis deviation; leukocyte adhesio... |
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| GDH | glucose dehydrogenase; glutamate dehydrogenase; glycerophosphate dehydrogenase; glycol dehydrogenase... |
| PDH | past dental history; phosphate dehydrogenase; position-of-the-dynamometer-handle [test]; progressive... |
| Parkinson's Disease Foundation; peritoneal dialysis fluid; Portable Document Format; pyruvate dehydr... | |
| PDHA | pyruvate dehydrogenase alpha |
| LipDH | Lipoamide dehydrogenase |
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| PDHC | Pyruvate Dehydrogenase Complex |
| PDH | Pyruvate dehydrogenase |
| PDC | Pyruvate dehydrogenase complex |
| PDK | Pyruvate dehydrogenase kinase |
| pyruvate dehydrogenase (lipoamide) | An oxidoreductase catalyzing conversion of pyruvate and (oxidised) lipoamide to CO2 and S6-acetyldihydrolipoamide in two successive reactions: the first between pyruvate and thiamin pyrophosphate to yield CO2 and alpha-hydroxyethylthiamin pyrophosphate (active pyruvate); the second between the last named and lipoamide to regain the thiamin pyrophosphate and yield S6-acetylhydrolipoamide. Compare: alpha-ketodecarboxylase. (05 Mar 2000) |
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| pyruvate dehydrogenase (lipoamide)-phosphatase | <enzyme> (pyruvate dehydrogenase (lipoamide))-phosphate phosphohydrolase. A mitochondrial enzyme that catalyses the hydrolytic removal of a phosphate on a specific seryl hydroxyl group of pyruvate dehydrogenase, reactivating the enzyme complex. Registry number: EC 3.1.3.43 (12 Dec 1998) |
| (pyruvate dehydrogenase (lipoamide))kinase | Registry number: EC 2.7.1.99 Synonym: pyruvate dehydrogenase kinase (26 Jun 1999) |
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| lipoamide dehydrogenase | <enzyme> An enzyme that regenerates lipoamide from the reduced form dihydrolipoamide. (18 Nov 1997) |
| pyruvate dehydrogenase | <enzyme> A complex multienzyme system that catalyses the conversion of (pyruvate + CoA + NAD) to (acetyl CoA + CO2 + NAD). (18 Nov 1997) |
| pyruvate dehydrogenase complex | <enzyme> A complex multienzyme system that catalyses the conversion of (pyruvate + CoA + NAD) to (acetyl CoA + CO2 + NAD). (18 Nov 1997) |
| pyruvate dehydrogenase complex deficiency | An autosomal recessive pyruvate metabolism disorder resulting from deficient enzyme activity in one of several proteins of pyruvate dehydrogenase complex, resulting in deficiency of acetyl CoA. Deficiency in acetyl CoA product reduces the synthesis of acetylcholine, thereby causing neurological abnormalities. Clinical presentations include lactic acidosis, mental retardation, and ataxia. (12 Dec 1998) |
| pyruvate dehydrogenase complex inactivase | <enzyme> Pharmacological action: enzyme inhibitor Registry number: EC 3.4.- (26 Jun 1999) |
| pyruvate dehydrogenase (cytochrome) | An oxidoreductase catalyzing reaction between ferricytochrome b1 and pyruvate to yield acetate and CO2, and ferrocytochrome b1. (05 Mar 2000) |
| lipoamide | <biochemistry> The functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group. (18 Nov 1997) |
| lipoamide disulfide | Oxidised lipoic acid in amide combination with the &vepsilon;-amino group of an l-lysyl residue of pyruvic acid dehydrogenase. (05 Mar 2000) |
| lipoamide reductase | <enzyme> An enzyme oxidizing dihydrolipoamide at the expense of NAD+; completes the oxidative decarboxylation of pyruvate; a part of several enzyme complexes (e.g., alpha-ketoglutarate dehydrogenase complex). Decreased activity leads to neuronal loss in brain resulting in psychomotor retardation. Synonym: coenzyme factor, lipoamide dehydrogenase, lipoamide reductase (NADH), lipoyl dehydrogenase. (05 Mar 2000) |
| active pyruvate | An intermediate formed in the oxidative decarboxylation of pyruvate. Compare: pyruvate dehydrogenase (lipoamide). Synonym: alpha-lactyl-thiamin pyrophosphate. (05 Mar 2000) |
| beta-alanine-pyruvate aminotransferase | <enzyme> An enzyme that reversibly transfers the amino group of beta-alanine to paruvate, thus producing l-alanine and malonate saemialdehyde. A deficiency of this enzyme is believed to be the cause of hyper-beta-alaninaemia. (05 Mar 2000) |
| beta-aminoisobutyrate:pyruvate aminotransferase | Beta-aminosiobutyrate:pyruvate transaminase;an enzyme that catalyses the reversible transfer of an amino group from beta-aminoisobutyrate to pyruvate, producing l-alanine and methylmalonate saemialdehyde. A step in valine degradation. A deficiency of beta-aminoisobutyrate:pyruvate aminotransferase results in hyper-beta-aminoisobutyric aciduria. (05 Mar 2000) |
| valine-pyruvate transaminase | <enzyme> E coli enzyme catalyzing the terminal step of valine biosynthesis; consider also EC 2.6.1.42, branched-chain-amino-acid transaminase; alanine-alpha-oxoisovalerate aminotransferase and alanine-alpha-ketoisovalerate aminotransferase were ens to alanine aminotransferase 1981-93 Registry number: EC 2.6.1.66 Synonym: alanine-valine transaminase, transaminase c, alanine alpha-ketoisovalerate aminotransferase, alanine-alpha-oxoisovalerate aminotransferase, alanine-alpha-ketoisovalerate aminotransferase (26 Jun 1999) |
| glutamine-pyruvate aminotransferase | <enzyme> Consider also glutamine transaminase k if cysteine conjugate beta-lyase activity is also present; l-methionine can act as donor; glyoxylate can act as acceptor Registry number: EC 2.6.1.15 Synonym: glutamine alpha-ketoacid transaminase, glutamine transaminase, glutamine transaminase l, glutamine oxo-acid aminotransferase, glutaminase II, glutamine aminotransferase, l-methionine aminotransferase (26 Jun 1999) |
Synonyms : Pyruvate Decarboxylase (Lipoamide), Pyruvate Dehydrogenase Component E1, Pyruvate Dehydrogenase-E1, Pyruvate Dehydrogenase E1
Synonyms : Pyruvate Dehydrogenase Phosphate Phosphatase, Phosphatase, PDH, Phosphatase, Pyruvate Dehydrogenase
| pyruvate dehydrogenase (lipoamide) |
[EC 1.2.4.1] an enzyme of the oxidoreductase class that is a component of the multienzyme pyruvate dehydrogenase complex (q.v.). The enzyme catalyzes the oxidative decarboxylation of pyruvate, forming acetyl bound to the cofactor thiamine pyrophosphate; the acetyl is subsequently transferred to lipoamide to form acetyldihydrolipoamide, an intermediate in the overall reaction catalyzed by the complex. Deficiency of the enzyme causes lacticacidemia, ataxia, psychomotor retardation, and sometimes lactic acidosis.
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
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