| DS | dead air space; dead space; deep sedative; deep sleep; defined substrate; dehydroepiandrosterone sul... |
|---|---|
| CS | calf serum; campomelic syndrome; carcinoid syndrome; cardiogenic shock; caries-susceptible; carotid ... |
| TS | Takayasu syndrome; Tay-Sachs; temperature sensitivity; temperature, skin; temporal stem; tensile str... |
| US/LS | upper strength/lower strength [ratio] |
| DABP | D site albumin promoter binding protein |
| DTS | Diametral tensile strength |
|---|---|
| ES | Ego Strength |
| HGS | Handgrip strength |
| IS | Ionic Strength |
| LISS | Low ionic strength solutions |
| constituative promoter | An unregulated promoter that allows for continual transcription of itsassociated gene. (09 Oct 1997) |
|---|---|
| promoter | <molecular biology> A region of DNA to which RNA polymerase binds before initiating the transcription of DNA into RNA. The nucleotide at which transcription starts is designated +1 and nucleotides are numbered from this with negative numbers indicating upstream nucleotides and positive downstream nucleotides. most bacterial promoters contain two consensus sequences that seem to be essential for the binding of the polymerase. The first, the Pribnow box, is at about 10 and has the consensus sequence 5' TATAAT 3'. The second, the 35 sequence, is centred about 35 and has the consensus sequence 5' TTGACA 3'. most factors that regulate gene transcription do so by binding at or near the promoter and affecting the initiation of transcription. Much less is known about eukaryote promoters, each of the three RNA polymerases has a different promoter. RNA polymerase I recognises a single promoter for the precursor of rRNA. RNA polymerase II, that transcribes all genes coding for polypeptides, recognises many thousands of promoters. most have the Goldberg Hogness or TATA box that is centred around position 25 and has the consensus sequence 5' TATAAAA 3'. Several promoters have a CAAT box around 90 with the consensus sequence 5' GGCCAATCT 3'. There is increasing evidence that all promoters for housekeeping genes contain multiple copies of a GC rich element that includes the sequence 5' GGGCGG 3'. Transcription by polymerase II is also affected by more distant elements known as enhancers. RNA polymerase III synthesises 5s ribosomal RNA, all tRNAs and a number of small RNAs. The promoter for RNA polymerase III is located within the gene either as a single sequence, as in the 5s RNA gene or as two blocks, as in all tRNA genes. (13 Nov 1997) |
| promoter insertion | <molecular biology> Activation of a gene by the nearby integration of a virus. The long-terminal repeat acts as a promoter for the host gene. A form of insertional mutagenesis. (18 Nov 1997) |
| promoter regions | <genetics> DNA sequences which are recognised (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the pribnow box in bacteria and the tata box in eukaryotes. (12 Dec 1998) |
| down promoter mutation | <molecular biology> A mutation (a change in base pair sequence) in a promoter region, this results in lower gene expression (less transcription of the gene occurs). (09 Oct 1997) |
| tumour promoter | <molecular biology, oncology> Agent that in classical studies of carcinogenesis in rodent skin was able to increase the sensitivity of tumour formation by a previously applied primary carcinogen, but was unable to induce tumours when used alone. Important example was croton oil, active ingredients of which are now believed to be phorbol esters. These are believed to act as analogues of diacylglycerols and may activate protein kinase C. Strictly speaking, not the same as a co carcinogen, which is defined as being active when administered at the same time. Tumour promoters generally are carcinogens when tested more stringently. (18 Nov 1997) |
| up promoter mutation | A mutation that increases the frequency of initiation of transcription. (05 Mar 2000) |
| associative strength | In psychology, the strength of a stimulus response linkage as measured by the frequency with which a stimulus elicits a particular response. See: conditioning. (05 Mar 2000) |
| biting strength | The motive force created by the dynamic action of the muscles during the physiologic act of mastication. Synonym: biting strength, masticatory force. (05 Mar 2000) |
| compressive strength | The maximum compression a material can withstand without failure. (12 Dec 1998) |
| hand strength | Force exerted when gripping or grasping. (12 Dec 1998) |
| strength | 1. The quality or state of being strong; ability to do or to bear; capacity for exertion or endurance, whether physical, intellectual, or moral; force; vigor; power; as, strength of body or of the arm; strength of mind, of memory, or of judgment. "All his [Samson's] strength in his hairs were." (Chaucer) "Thou must outlive Thy youth, thy strength, thy beauty." (Milton) 2. Power to resist force; solidity or toughness; the quality of bodies by which they endure the application of force without breaking or yielding; in this sense opposed to frangibility; as, the strength of a bone, of a beam, of a wall, a rope, and the like. "The brittle strength of bones." 3. Power of resisting attacks; impregnability. "Our castle's strength will laugh a siege to scorn." 4. That quality which tends to secure results; effective power in an institution or enactment; security; validity; legal or moral force; logical conclusiveness; as, the strength of social or legal obligations; the strength of law; the strength of public opinion; strength of evidence; strength of argument. 5. One who, or that which, is regarded as embodying or affording force, strength, or firmness; that on which confidence or reliance is based; support; security. "God is our refuge and strength." (Ps. Xlvi. 1) "What they boded would be a mischief to us, you are providing shall be one of our principal strengths." (Sprat) "Certainly there is not a greater strength against temptation." (Jer. Taylor) 6. Force as measured; amount, numbers, or power of any body, as of an army, a navy, and the like; as, what is the strength of the enemy by land, or by sea? 7. Vigor or style; force of expression; nervous diction; said of literary work. "And praise the easy vigor of a life Where Denham's strength and Waller's sweetness join." (Pope) 8. Intensity; said of light or colour. "Bright Phoebus in his strength." (Shak) 9. Intensity or degree of the distinguishing and essential element; spirit; virtue; excellence; said of liquors, solutions, etc.; as, the strength of wine or of acids. 10. A strong place; a stronghold. On, or Upon, the strength of, in reliance upon. "The allies, after a successful summer, are too apt, upon the strength of it, to neglect their preparations for the ensuing campaign." . Synonym: Force, robustness, toughness, hardness, stoutness, brawniness, lustiness, firmness, puissance, support, spirit, validity, authority. See Force. Origin: OE. Strengthe, AS. Strengu, fr. Strang strong. See Strong. Source: Websters Dictionary (01 Mar 1998) |
| strength-duration curve | A graph relating the intensity of an electrical stimulus to the length of time it must flow to be effective. See: chronaxie, rheobase. (05 Mar 2000) |
| ionic strength | Symbolised as g/2 or I and set equal to 0.5σmizi2, where mi equals the molar concentration and zi the charge of each ion present in solution; if molar concentrations (ci) are used instead of molality (and the solution is dilute), then I == 0.5(1/ρo)σcizi2 where ρo is the density of the solvent; a number of biochemically important events (e.g., protein solubility and rates of enzyme action) vary with the ionic strength of a solution. (05 Mar 2000) |
| tensile strength | The maximum stress a material subjected to a stretching load can withstand without tearing. (12 Dec 1998) |
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