| DABP | D site albumin promoter binding protein |
|---|---|
| ESP | early systolic paradox; echo spacing; effective sensory projection; effective systolic pressure; end... |
| GPE | guinea pig embryo; granulocyte colony-stimulating factor promoter element |
| GPEBP | granulocyte colony-stimulating factor promoter element binding protein |
| NTR | 3'-non-translated regions |
|---|---|
| CDR | Complementarity Determining Regions |
| CR | Conserved Regions |
| SRO | Smallest regions of overlap |
| AgNORs | staining of nucleolar organiser regions |
| promoter regions | <genetics> DNA sequences which are recognised (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the pribnow box in bacteria and the tata box in eukaryotes. (12 Dec 1998) |
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| constituative promoter | An unregulated promoter that allows for continual transcription of itsassociated gene. (09 Oct 1997) |
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| promoter | <molecular biology> A region of DNA to which RNA polymerase binds before initiating the transcription of DNA into RNA. The nucleotide at which transcription starts is designated +1 and nucleotides are numbered from this with negative numbers indicating upstream nucleotides and positive downstream nucleotides. most bacterial promoters contain two consensus sequences that seem to be essential for the binding of the polymerase. The first, the Pribnow box, is at about 10 and has the consensus sequence 5' TATAAT 3'. The second, the 35 sequence, is centred about 35 and has the consensus sequence 5' TTGACA 3'. most factors that regulate gene transcription do so by binding at or near the promoter and affecting the initiation of transcription. Much less is known about eukaryote promoters, each of the three RNA polymerases has a different promoter. RNA polymerase I recognises a single promoter for the precursor of rRNA. RNA polymerase II, that transcribes all genes coding for polypeptides, recognises many thousands of promoters. most have the Goldberg Hogness or TATA box that is centred around position 25 and has the consensus sequence 5' TATAAAA 3'. Several promoters have a CAAT box around 90 with the consensus sequence 5' GGCCAATCT 3'. There is increasing evidence that all promoters for housekeeping genes contain multiple copies of a GC rich element that includes the sequence 5' GGGCGG 3'. Transcription by polymerase II is also affected by more distant elements known as enhancers. RNA polymerase III synthesises 5s ribosomal RNA, all tRNAs and a number of small RNAs. The promoter for RNA polymerase III is located within the gene either as a single sequence, as in the 5s RNA gene or as two blocks, as in all tRNA genes. (13 Nov 1997) |
| promoter insertion | <molecular biology> Activation of a gene by the nearby integration of a virus. The long-terminal repeat acts as a promoter for the host gene. A form of insertional mutagenesis. (18 Nov 1997) |
| down promoter mutation | <molecular biology> A mutation (a change in base pair sequence) in a promoter region, this results in lower gene expression (less transcription of the gene occurs). (09 Oct 1997) |
| tumour promoter | <molecular biology, oncology> Agent that in classical studies of carcinogenesis in rodent skin was able to increase the sensitivity of tumour formation by a previously applied primary carcinogen, but was unable to induce tumours when used alone. Important example was croton oil, active ingredients of which are now believed to be phorbol esters. These are believed to act as analogues of diacylglycerols and may activate protein kinase C. Strictly speaking, not the same as a co carcinogen, which is defined as being active when administered at the same time. Tumour promoters generally are carcinogens when tested more stringently. (18 Nov 1997) |
| up promoter mutation | A mutation that increases the frequency of initiation of transcription. (05 Mar 2000) |
| abdominal regions | The topographical subdivisions of the abdomen; based on subdividing the abdomen by the transpyloric, interspinous and midclavicular planes; including the right and left hypochondriac, right and left lateral, right and left inguinal, and the unpaired epigastric, umbilical and pubic regions. Synonym: regiones abdominis, abdominal zones. (05 Mar 2000) |
| antarctic regions | The continent lying around the south pole and the southern waters of the atlantic, pacific, and indian oceans. It includes the falkland islands dependencies. (12 Dec 1998) |
| arctic regions | The arctic ocean and the lands in it and adjacent to it. It includes point barrow, alaska, most of the franklin district in canada, two thirds of greenland, svalbard, franz josef land, lapland, novaya zemlya, and northern siberia. (12 Dec 1998) |
| body regions | Anatomical areas of the body. (12 Dec 1998) |
| regions of back | The topographical regions of the back of the trunk, including the vertebral region, sacral region, scapular region, infrascapular region, and lumbar region. Synonym: regiones dorsales. (05 Mar 2000) |
| regions of body | The topographical divisions of the body. Synonym: regiones corporis. (05 Mar 2000) |
| regions of chest | The topographic divisions of the chest: presternal, mammary, inframammary, and axillary. See: pectoral region. Synonym: regiones pectorales. (05 Mar 2000) |
| regions of face | The topographical subdivisions of the face, including nasal, oral, mental, orbital, infraorbital, buccal, and zygomatic. Synonym: regiones faciales. (05 Mar 2000) |
| regions of head | The topographical division of the cranium in relation to the bones of the cranial vault; the regions include frontal, parietal, occipital, and temporal. Synonym: regiones capitis. (05 Mar 2000) |
Synonyms : Promoter, Promoter Regions, Promotor, Promotor (Genetics), Promotor Regions, Promotor Regions (Genetics), Pseudopromoter, Early Promoter, Late Promoter, Middle Promoter, Promoter Region, Promoter Region (Genetics), Promoter, Early, Promoter, Late, Promoter, Middle
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