¼±Åà - È­»ìǥŰ/¿£ÅÍŰ ´Ý±â - ESC

 
"primary refractory anaemia"¿¡ ´ëÇÑ °Ë»ö °á°úÀÔ´Ï´Ù. °Ë»ö °á°ú º¸´Â µµÁß¿¡ Tab ۸¦ ´©¸£½Ã¸é °Ë»ö âÀÌ ¼±Åõ˴ϴÙ.
À̰ÍÀ» ¿øÇϼ̽À´Ï±î?
´ëÇÑÀÇÇù ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • absolute refractory period
    Àý´ëºÒÀÀ±â
  • functional refractory period
    ±â´ÉÀûºÒÀÀ±â
  • refractory
    1. ºÒÀÀ-, ¹«¹ÝÀÀ¼º- 2. Ä¡·áÀúÇ×¼º-, ³­Ä¡¼º-
  • refractory investment
    ³»È­¸Å¸ôÁ¦
  • refractory normoblastic anemia
    ³­Ä¡¼ºÁ¤»óÀûÇ÷¸ð±¸ºóÇ÷
  • refractory period
    ºÒÀÀ±â
  • refractory rickets
    ºñŸ¹ÎDºÒÀÀ±¸·çº´, ºÒÀÀ¼º±¸·çº´
  • refractory state
    ºÒÀÀ»óÅÂ
  • relative refractory period
    »ó´ëºÒÀÀ±â
  • delayed primary suture
    Áö¿¬ÀÏÂ÷ºÀÇÕ
  • primary
    ÀÏÂ÷-, ¿ø¹ß-
  • primary action
    ÀÏÂ÷ÀÛ¿ë
  • primary affect hunger
    ÀÏÂ÷Á¤µ¿°¥¸Á, ÀÏÂ÷¾ÖÁ¤°¥¸Á
  • primary aldosteronism
    ¿ø¹ß¾Ëµµ½ºÅ×·ÐÁõ
  • primary amebic meningoencephalitis
    ¿ø¹ß¾Æ¸Þ¹Ù¼ö¸·³ú¿°
´ëÇÑÀÇÇù Çʼö ÀÇÇпë¾îÁý »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • refractory period
    ºÒÀÀ±â
  • refractory state
    ¹«¹ÝÀÀ»óÅÂ
  • primary aldosteronism
    ÀÏÂ÷¾Ëµµ½ºÅ×·ÐÁõ
  • primary cancer
    ¿ø¹ß¾Ï
  • primary constriction
    (¢¡centromere) ¸Åµì, µ¿¿øÃ¼, Áß½ÉÀý
  • primary health care
    ÀÏÂ÷º¸°ÇÀÇ·á
  • primary cholestatic liver disease
    ÀÏÂ÷¾µ°³ÁóÁ¤Ã¼°£Áúȯ, ÀÏÂ÷´ãÁóÁ¤Ã¼°£Áúȯ
  • primary irritant dermatitis
    ¿ø¹ßÀÚ±ØÇǺο°
  • primary infection
    ÀÏÂ÷°¨¿°
  • primary
    ¿ø¹ß-, ÀÏÂ÷-
  • primary polydipsia
    ¿ø¹ß¼º´ÙÀ½Áõ, ÀÏÂ÷Àû´ÙÀ½Áõ, ¿ø¹ß¼º´ÙÀ½´Ù°¥Áõ, ÀÏÂ÷Àû´ÙÀ½´Ù°¥Áõ
  • spontaneous primary peritonitis
    ¿ø¹ßº¹¸·¿°, ÀÏÂ÷º¹¸·¿°, ¿ø¹ß¹è¸·¿°, ÀÏÂ÷¹è¸·¿°
  • primary stage
    Ãʱâ
  • primary suture
    ÀÏÂ÷ºÀÇÕ
  • occult primary tumor
    Àẹ¿ø¹ßÁ¾¾ç
¿¾ ´ëÇÑÀÇÇù ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • absolute refractory period
    Àý´ëºÒÀÀ±â
  • normoblastic refractory anemia
    Á¤»óÀûÇ÷¸ð±¸Áö¿¬¹ÝÀÀºóÇ÷
  • functional refractory period
    ±â´ÉÀûºÒÀÀ±â
  • refractory investment
    ³»È­¸Å¸ôÁ¦
  • platelet immunologic refractory state
    Ç÷¼ÒÆÇ¸é¿ªºÒÀÀ»óÅÂ
  • refractory period
    ºÒÀÀ±â
  • relative refractory period
    »ó´ëºÒÀÀ±â
  • refractory rickets
    (¢¡vitamin D-resistant rickets) ºñŸ¹ÎµðÀúÇ×±¸·íº´
  • refractory state
    ¹«¹ÝÀÀ»óÅÂ
  • primary action
    ÀÏÂ÷ÀÛ¿ë, ÀÏÂ÷±â´É
  • primary amenorrhea
    ¿ø¹ß¹«¿ù°æ, ÀÏÂ÷¹«¿ù°æ
  • primary amnion
    ¿ø½Ã¾ç¸·, ÀÏÂ÷¾ç¸·
  • primary amyloidosis
    ¿ø¹ß¾Æ¹Ð·ÎÀ̵åÁõ
  • primary aqueous
    ¿ø¹æ¼ö, ÀÏÂ÷¹æ¼ö
  • primary olfactory receiving area
    ÀÏÂ÷Èİ¢¿µ¿ª
¿¾ ´ëÇÑÀÇÇù 2 ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • alimentary anemia<³ª> anaemia alimentria
    ½Ä»ç¼º ºóÇ÷(?Ë×Ì´).
  • absolute refractory period
    Àý´ëºÒÀÀ±â(¡­ÝÕëëÑ¢)
  • histamin refractory
    È÷½ºÅ¸¹Î¹«¹ÝÀÀ¼º(¡­ÙíÚãëëàõ)ÀÇ.
  • platelet immunologic refractory state
    Ç÷¼ÒÆÇ¸é¿ªÇÐÀû ºÒÀÀ»óÅÂ(ÝÕëëßÒ÷¾)
  • refractory investment
    ³»È­¸Å¸ôÁ¦(Ò±ûýØØÙÒð¥).
  • refractory megaloblastic anemia
    Ç×Ä¡·á¼º°ÅÀû¾Æ±¸ºóÇ÷(ùñö½èþàõËÝîåä´Ï¹Þ¸ úì).
  • refractory megaloblastic anemia
    Ç×Ä¡·á¼º°ÅÀû¾Æ±¸ºóÇ÷(ùñö½èþàõËÝîåä´Ï¹Þ¸úì)
  • refractory otalgia
    ³­Ä¡(¼º) ÀÌÅë
  • refractory otalgia
    ³­Ä¡¼º ÀÌÅë(Ññö½àõì¼÷Ô)
  • refractory rickets
    ³­Ä¡±¸·çº´(Ññö½ ׬ܻ).
  • refractory rickets
    ³­Ä¡±¸·çº´(Ññö½ ׬ܻ)
  • refractory sideroblastic anemia
    ºÒÀÀ¼ºÃ¶Àû¸ð±¸ºóÇ÷
  • refractory state
    ºÒÀÀ»óÅÂ, ¹«¹ÝÀÀ»óÅÂ
  • relative refractory period
    »ó´ë(Àû) ºÒÀÀ±â(ßÓÓßîÜÝÕëëÑ¢).
  • primary yolk sac [primary vitellin sac]
    ÀÏÂ÷³­È²ÁÖ¸Ó´Ï
¿¾ ´ëÇÑÀÇÇù 3 ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • alimentary anemia<³ª> anaemia alimentria
    ½Ä»ç¼º ºóÇ÷(?Ë×Ì´).
  • primary yolk sac [primary vitellin sac]
    ÀÏÂ÷³­È²ÁÖ¸Ó´Ï
  • primary yolk sac [primary vitelline sac]
    ÀÏÂ÷³­È²ÁÖ¸Ó´Ï
  • primary yolk sac[primary vitelline sac]
  • primary yolk sac[primary vitelline sac]
  • absolute refractory period
    Àý´ëºÒÀÀ±â(¡­ÝÕëëÑ¢)
  • histamin refractory
    È÷½ºÅ¸¹Î¹«¹ÝÀÀ¼º(¡­ÙíÚãëëàõ)ÀÇ.
  • normoblastic refractory anemia
    À̸Ï(Ç÷¾×)Á¤Àû¸ð±¸¼º ºÒÀÀ¼º ºóÇ÷(ïáîåٽϹàõÝÕëëàõÞ¸ úì).
  • platelet immunologic refractory state
    Ç÷¼ÒÆÇ¸é¿ªÇÐÀû ºÒÀÀ»óÅÂ(ÝÕëëßÒ÷¾)
  • refractory anemia
    ºÒÀÀ¼º ºóÇ÷
  • refractory anemia
    ºÒÀÀ¼º ºóÇ÷(ÝÕëëàõÞ¸úì).
  • refractory anemia
    ºÒÀÀ¼º ºóÇ÷(ÝÕëëàõÞ¸úì)
  • refractory anemia relapsing polychondroritis
  • refractory anemia with excess blast =RAEB
    ¸ð¼¼Æ÷°ú´ÙºÒÀÀ¼ººóÇ÷
  • refractory anemia with excess blasts
    ¸ð¼¼Æ÷°ú´Ù¼º ºÒÀÀ¼ººóÇ÷
´ëÇÑÇØºÎÇÐȸ ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • Primary yolk sac [Primary vitellin sac]
    ÀÏÂ÷³­È²ÁÖ¸Ó´Ï
    [¿¾ ¿ë¾î] ÀÏÂ÷³­È²³¶
  • Primary yolk sac [Primary vitelline sac]
    ÀÏÂ÷³­È²ÁÖ¸Ó´Ï
    [¿¾ ¿ë¾î] ÀÏÂ÷³­È²³¶
  • Diploid primary gametocyte
    µÎ¹è¼öüÀÏÂ÷»ý½Ä¼¼Æ÷
    [¿¾ ¿ë¾î] ¹è¼öüÁ¦ÀÏ»ý½Ä¼¼Æ÷
  • Reticulofibrous membranous bone [Primary membranous bone]
    ¼¼¸Á¼¶À¯¸·»À [ÀÏÂ÷¸·»À]
    [¿¾ ¿ë¾î] ÀÏÂ÷¸·¼º°ñ
  • Premaxilla (Primary palate)
    ¾ÕÀ§ÅλÀ [ÀÏÂ÷ÀÔõÀå]
    [¿¾ ¿ë¾î] ¾ÇÀü±¸°³
  • Premaxilla [Primary palate]
    ¾ÕÀ§ÅλÀ [ÀÏÂ÷ÀÔõÀå]
    [¿¾ ¿ë¾î] Àü»ó¾Ç°ñ
  • Primary vitelline sac
    ¿ø½Ã³­È²ÁÖ¸Ó´Ï
    [¿¾ ¿ë¾î] ¿ø½Ã³­È²³¶
  • Primary amnion
    ¿ø½Ã¾ç¸·
    [¿¾ ¿ë¾î] ¿ø½Ã¾ç¸·
  • Primary medullary cavity
    ÀÏÂ÷°ñ¼ö°ø°£
    [¿¾ ¿ë¾î] ÀÏÂ÷°ñ¼ö°­
  • Primary medullary cavity
    ÀÏÂ÷°ñ¼ö°ø°£[ÀÏÂ÷»À¼ÓÁú°ø°£]
    [¿¾ ¿ë¾î] ÀÏÂ÷°ñ¼ö°­
  • Primary polar body
    ÀÏÂ÷±ØÃ¼
    [¿¾ ¿ë¾î] ÀÏÂ÷±ØÃ¼
  • Primary bronchus
    ÀÏÂ÷±â°üÁö
    [¿¾ ¿ë¾î] ¿ø½Ã±â°üÁö
  • Primary oocyte
    ÀÏÂ÷³­¸ð¼¼Æ÷
    [¿¾ ¿ë¾î] ÀÏÂ÷³­¸ð¼¼Æ÷
  • Primary follicle
    ÀÏÂ÷³­Æ÷
    [¿¾ ¿ë¾î] ÀÏÂ÷³­Æ÷
  • Primary ovarian follicle
    ÀÏÂ÷³­Æ÷
    [¿¾ ¿ë¾î] ¿ø½Ã³­Æ÷
´ëÇѱâ»ýÃæÇÐȸ ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 2 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • primary amebic meningoencephalitis
    ¿ø¹ß¼º¾Æ¸Þ¹Ù¼ö¸·³ú¿°
  • primary infection
    ÀÏÂ÷°¨¿°
´ëÇÑ»ýÈ­ÇкÐÀÚ»ý¹°ÇÐȸ ¿ë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • refractory prriod
    ºÒÀÀ±â(Ñ¢)
  • primary acidosis
    ¿ø¹ß¼º »êÁõ(ê«Û¡àõß«ñø)
  • primary active transport
    ÀÏÂ÷ ´Éµ¿¼ö¼Û(ìéó­ÒöÔÑâÃáê)
  • primary alkali deficit
    ¿ø¹ß¼º(ê«Û¡àõ) ¾ËÄ®¸®°áÇÌ(ÌÀù¹)
  • primary alkali excess
    ¿ø¹ß¼º(ê«Û¡àõ) ¾ËÄ®¸®°úÀ×(Φí¥)
  • primary alkalosis
    ¿ø¹ß¼º(ê«Û¡àõ) ¾ËÄ®¸®Áõ(ñø)
  • primary amino acid
    ÀÏÂ÷(ìéó­) ¾Æ¹Ì³ë»ê(ß«)
  • primary bile acid
    ÀÏÂ÷ ´ãÁó»ê(ìéó­ÓÅñðß«)
  • primary carbon dioxide deficit
    ¿ø¹ß¼º ÀÌ»êȭź¼Ò °áÇÌ(ê«Û¡àõì£ß«ûù÷©áÈÌÀù¹)
  • primary carbon dioxide excess
    ¿ø¹ß¼º ÀÌ»êȭź¼Ò(ê´Û¡àõ ì£ß«ûù÷©áÈ) °úÀ×(Φí¥)
  • primary charge effect
    ÀÏÂ÷ ÀüÇÏÈ¿°ú(ìéó­ï³ùÃüùÍý)
  • primary culture
    ÀÏÂ÷ ¹è¾ç(ìéó­ÛÆå×)
  • primary deficiency
    ¿ø¹ß¼º °áÇÌ(ê«Û¡àõÌÀù¹)
  • primary derived protein
    ÀÏÂ÷ À¯µµ ´Ü¹éÁú(ìéó­ë¯ÓôÓ±ÛÜòõ)
  • primary filament
    ÀÏÂ÷(ìéó­) Çʶó¸àÆ®
KI ÀÇÇпë¾î »çÀü °Ë»ö À¯»ç °Ë»ö °á°ú : 13 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
  • primary
    ÀÏÂ÷(¼º)ÀÇ, Á¦ÀÏÀÇ, ÃʱâÀÇ, ¿ø¹ß(¼º)ÀÇ
  • primary amenorrhea
    ¿ø¹ß(¼º)¹«¿ù°æ
  • primary cancer
    ¿ø¹ß¾Ï
  • primary complex
    Ãʱ⺯ȭ±º
  • primary hypertension
    ¿ø¹ß(¼º)°íÇ÷¾ÐÁõ
  • primary infection
    ÀÏÂ÷°¨¿°
  • primary infiltration
    ÃʱâħÀ±
  • primary lesion
    ÀÏÂ÷¼ºº´º¯, Ãʰ¨¿°¼Ò
  • primary lobule
    ÀÏÂ÷¼Ò¿±
  • primary ossification center
    ÀÏÂ÷°ñÈ­Áß½É
  • primary ray
    ÀÏÂ÷¼±
  • primary tuberculosis
    ÀÏÂ÷°áÇÙ(Áõ), Ãʱâ°áÇÙ(Áõ)
  • primary tumor
    ¿ù¹ßÁ¾¾ç
KMLE ÀÇÇоà¾î »çÀü À¯»ç °Ë»ö °á°ú : 5 ÆäÀÌÁö: 1
MDS Myelo-Dysplastic Syndrome
  = Refractory (Dysmyelopoietic) Anemia
  = (Id...
AERP antegrade effective refractory period; atrial effective refractory period
RA radioactive; ragocyte; ragweed antigen; rapidly adapting [receptors]; reactive arthritis; reciprocal...
DEF decayed primary teeth requiring filling, decayed primary teeth requiring extraction, and primary tee...
PA panic attack; pantothenic acid; paralysis agitans; paranoia; passive aggressive; pathology; patient'...
KMLE ÀÚµ¿ÃßÃâ ÀÇÇоà¾î »çÀü À¯»ç °Ë»ö °á°ú : 5 ÆäÀÌÁö: 1
RA Refractory anaemia
RAEB Refractory anaemia with excess of blasts
RAEB refractory anaemia with an excess of blasts
RAEB refractory anaemia with excess blasts
RAEB-t refractory anaemia with excess of blasts 'in transformation
°æºÏ´ë Ä¡°ú´ëÇÐ ±¸°­³»°ú ±³½Ç »çÀü À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
  • ¿µ¹®
    ÇѱÛ
    ¼³¸í
  • refractory cast
    ³»È­¼º ¸ðÇü
    ºÐÇØµÇÁö ¾Ê°í °í¿­À» °ßµô ¼ö ÀÖ´Â Àç·á·Î ¸¸µé¾îÁø ¸ðÇüÀ¸·Î¼­, ±¹¼Ò ÀÇÄ¡ ÁÖÁ¶¼ú¿¡ »ç¿ëµÉ ¶§ ÆØÃ¢ÇÏ¿© ±Ý¼ÓÀÇ ¼öÃàÀ» º¸»óÇÑ´Ù.
  • refractory investment
    ³»È­ ¸Å¸ôÁ¦, ³»È­¼º ¸Å¸ôÀç
    ³³ÂøÀ̳ª ÁÖÁ¶¿¡ »ç¿ëµÇ´Â °í¿Â¿¡ °ßµô¼ö ÀÖ´Â ¸Å¸ôÀç.
  • refractory mold
    ³»È­¼º ¸ôµå
  • sideroblastic refractory anemia
    ö Àû¸ð±¸¼º ºÒÀÀ¼º ºóÇ÷
  • primary vaccination :

    primary's area

    Á¦1¿µ¿ª
    ¿îµ¿°ú °¨°¢ºÎ¸¦ Æ÷ÇÔÇÏ´Â ´ë³ú ÇÇÁú ¿µ¿ª.
  • A alpha primary afferent
    A ¾ËÆÄ ÀÏÂ÷ ±¸½É ½Å°æ
    ±Ù¹æÃß ³»ÀÇ ±Ù ¼¶À¯¿¡ Á¸ÀçÇÏ´Â °¨°¢½Å°æÀÇ Çϳª·Î ¥°a °¨°¢ ½Å°æÀ̶ó°íµµ ÇÑ´Ù. Á÷°æÀº 22§­, Àüµµ ¼Óµµ´Â 120§½ÀÌ´Ù.
  • C primary afferent nociceptor
    C ÀÏÂ÷ ±¸½É¼º Ä§ÇØ ¼ö¿ëü, C ÀÏÂ÷ ±¸½É¼º À¯ÇØ ¼ö¿ë±â
  • early primary closure
    Á¶±â 1Â÷ ºÀÇÕ
  • ensitization 1. administration of antigen to induce a primary immune response; priming; immunization. 2. exposure to allergen that results in the development of hypersensitivity. 3. the coating of erythrocytes with antibody so that they are subject to lys
    ³»¹ø
    ƯÈ÷ ¾È°Ë ¿¬ÀÇ.
  • myelinated primary afferent
    ÀÏÂ÷ À¯¼öÃÊ ±¸½É ½Å°æ
  • nociceptive primary afferent
    Ä§ÇØ ¼ö¿ë¼º ÀÏÂ÷ ±¸½É ½Å°æ, À¯ÇØ ¼ö¿ë¼º ÀÏÂ÷ ±¸½É ½Å°æ
  • non-nociceptive A delta C primary afferent
    ºñÄ§ÇØ ¼ö¿ë¼º A µ¨Å¸ C ÀÏÂ÷ ±¸½É ½Å°æ, ºñÀ¯ÇØ ¼ö¿ë¼º A µ¨Å¸ C ÀÏÂ÷ ±¸½É ½Å°æ
  • non-nociceptive myelinated primary afferent
    ºñÄ§ÇØ ¼ö¿ë¼º ÀÏÂ÷ ±¸½É ¼¶À¯, ºñÀ¯ÇØ ¼ö¿ë¼º ÀÏÂ÷ ±¸½É ¼¶À¯
  • primary
    ÀÏÂ÷¼º, ¿ø¹ß¼º, ¿ø¹ß¼ºÀÇ, ÀÏÂ÷, ÀÏÂ÷ÀÇ, ÀÏÂ÷¼ºÀÇ, Á¦ÀÏÀÇ, ÃʱâÀÇ, ¿ø¹ßÀÇ, ÁÖµÈ
    ¹ß»ýµÇ´Â ½Ã±âÀÇ ¼ø¼­¿¡ À־ óÀ½ÀÎ.
  • primary adaptation
    ÀÏÂ÷ ¼øÀÀ, ÀÏÂ÷¼º ¼øÀÀ
CancerWEB ¿µ¿µ ÀÇÇлçÀü ¸ÂÃã °Ë»ö °á°ú : 1 ÆäÀÌÁö: 1
primary refractory anaemia Any of a group of anaemic conditions in which there is persistent, frequently advanced anaemia that is not successfully treated by any means except blood transfusions, and that is not associated with another primary disease.
(05 Mar 2000)
CancerWEB ¿µ¿µ ÀÇÇлçÀü À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
anaemia, refractory Anaemia (a shortage of red blood cells) unresponsive to treatment.
(12 Dec 1998)
anaemia, refractory, with excess of blasts Chronic refractory anaemia with granulocytopenia, and/or thrombocytopenia. Myeloblasts and progranulocytes constitute 5 to 40 percent of the nucleated marrow cells.
(12 Dec 1998)
refractory anaemia <haematology> A form of myelodysplasia which primarily affects the red cell production by the bone marrow.
In some cases the developing red cells show an internal ring of iron granules. These cells are called sideroblasts. Refractory anaemia and refractory anaemia with sideroblasts are the most common forms of myelodysplasia.
Origin: Gr. Haima = blood
(13 Nov 1997)
refractory anaemia with excess blasts <haematology> A form of myelodysplasia characterised by the build up of immature white blood cells (blasts) in the bone marrow.
If the immature cells are particularly numerous it may indicate a chance of transformation to acute leukaemia and the condition is called refractory anaemia with excess blasts in transformation (RAEBt).
Acronym: RAEB
(13 Nov 1997)
secondary refractory anaemia Any persistent anaemia that is successfully treated only by blood transfusions, and that is associated with another condition.
(05 Mar 2000)
primary erythroblastic anaemia The dire disease also known as beta thalassaemia. The clinical picture of this form of anaemia was first described in 1925 by the paediatrician thomas benton cooley. Other names for the disease are cooley's anaemia and mediterranean anaemia. The term thalassaemia was coined by the nobel prise winning pathologist george whipple and the professor of paediatrics william bradford at u. Of rochester because thalassa in greek means the sea (like the mediterrranean sea) + -aemia means in the blood so thalassaemia means sea in the blood. Thalassaemia is not just one disease. It is a complex contingent of genetic (inherited) disorders all of which involve underproduction of haemoglobin, the indispensable molecule in red blood cells that carries oxygen. The globin part of normal adult haemoglobin is made up of 2 alpha and 2 beta polypeptide chains. In beta thalassaemia, there is a mutation (change) in both beta globin chains leading to underproduction (or absence) of beta chains, underproduction of haemoglobin, and profound anaemia. The gene for beta thalassaemia is relatively frequent in people of mediterranean origin (for example, from italy and greece). Children with this disease inherit one gene for it from each parent (and so are said to be homozygous for beta thalassaemia). The parents are carriers (heterozygotes) with just one thalassaemia gene, are said to have thalassaemia minor, and are essentially normal. Their children affected with beta thalassaemia seem entirely normal at birth (because at birth we still have predominantly foetal haemoglobin which does not contain beta chains) but the anaemia emerges in the first few months of life and becomes progressively more severe leading to pallor and easy fatiguability, failure to thrive (grow), bouts of fever (due to infections) and diarrhoea. Treatment based on blood transfusions is helpful but not curative. Gene therapy will, it is hoped, be applicable to this disease.
(12 Dec 1998)
absolute refractory period The period following excitation when no response is possible regardless of the intensity of the stimulus.
(05 Mar 2000)
refractory Not readily yielding to treatment.
Origin: L. Refractorius
(18 Nov 1997)
refractory cast A cast made of material that will withstand the high temperatures of metal casting or soldering without disintegrating.
Synonym: investment cast.
(05 Mar 2000)
refractory flask A metal tube in which a refractory mold is made for casting metal dental restorations or appliances.
Synonym: casting flask, casting ring.
(05 Mar 2000)
refractory lining A lining, usually of ceramic, capable of resisting and maintaining high temperatures.
(05 Dec 1998)
refractory period <neurology, physiology> most commonly used in reference to the interval (typically 1ms) after the passage of an action potential during which an axon is incapable of responding to another. This is caused by inactivation of the sodium channels after opening. The maximum frequency at which neurons can fire is thus limited to a few hundred Hertz. An analogous refractory period occurs in individuals of Dictyostelium discoideum, which are insensitive to extracellular cyclic AMP immediately after a pulse of cAMP has been secreted.
The term can be applied to any system where a similar insensitive period follows stimulation.
(18 Nov 1997)
refractory period of electronic pacemaker The time required to restore full sensitivity after detecting cardiac activity or delivering a pacing impulse.
(05 Mar 2000)
refractory period, psychological A delayed response interval occurring when two stimuli are presented in close succession.
(12 Dec 1998)
refractory rickets Rickets that does not respond to treatment with usual doses of vitamin D and adequate dietary calcium and phosphorus. Most often due to inherited renal tubular disorder e.g., Fanconi syndrome.
Renal rickets, a form of rickets occurring in children in association with and apparently caused by renal disease with hyperphosphatemia.
Synonym: pseudorickets, renal fibrocystic osteosis, renal infantilism, renal osteitis fibrosa.
(05 Mar 2000)
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