| MDS | Myelo-Dysplastic Syndrome = Refractory (Dysmyelopoietic) Anemia = (Id... |
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| AERP | antegrade effective refractory period; atrial effective refractory period |
| RA | radioactive; ragocyte; ragweed antigen; rapidly adapting [receptors]; reactive arthritis; reciprocal... |
| DEF | decayed primary teeth requiring filling, decayed primary teeth requiring extraction, and primary tee... |
| PA | panic attack; pantothenic acid; paralysis agitans; paranoia; passive aggressive; pathology; patient'... |
| RA | Refractory anaemia |
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| RAEB | Refractory anaemia with excess of blasts |
| RAEB | refractory anaemia with an excess of blasts |
| RAEB | refractory anaemia with excess blasts |
| RAEB-t | refractory anaemia with excess of blasts 'in transformation |
primary's area
| primary refractory anaemia | Any of a group of anaemic conditions in which there is persistent, frequently advanced anaemia that is not successfully treated by any means except blood transfusions, and that is not associated with another primary disease. (05 Mar 2000) |
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| anaemia, refractory | Anaemia (a shortage of red blood cells) unresponsive to treatment. (12 Dec 1998) |
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| anaemia, refractory, with excess of blasts | Chronic refractory anaemia with granulocytopenia, and/or thrombocytopenia. Myeloblasts and progranulocytes constitute 5 to 40 percent of the nucleated marrow cells. (12 Dec 1998) |
| refractory anaemia | <haematology> A form of myelodysplasia which primarily affects the red cell production by the bone marrow. In some cases the developing red cells show an internal ring of iron granules. These cells are called sideroblasts. Refractory anaemia and refractory anaemia with sideroblasts are the most common forms of myelodysplasia. Origin: Gr. Haima = blood (13 Nov 1997) |
| refractory anaemia with excess blasts | <haematology> A form of myelodysplasia characterised by the build up of immature white blood cells (blasts) in the bone marrow. If the immature cells are particularly numerous it may indicate a chance of transformation to acute leukaemia and the condition is called refractory anaemia with excess blasts in transformation (RAEBt). Acronym: RAEB (13 Nov 1997) |
| secondary refractory anaemia | Any persistent anaemia that is successfully treated only by blood transfusions, and that is associated with another condition. (05 Mar 2000) |
| primary erythroblastic anaemia | The dire disease also known as beta thalassaemia. The clinical picture of this form of anaemia was first described in 1925 by the paediatrician thomas benton cooley. Other names for the disease are cooley's anaemia and mediterranean anaemia. The term thalassaemia was coined by the nobel prise winning pathologist george whipple and the professor of paediatrics william bradford at u. Of rochester because thalassa in greek means the sea (like the mediterrranean sea) + -aemia means in the blood so thalassaemia means sea in the blood. Thalassaemia is not just one disease. It is a complex contingent of genetic (inherited) disorders all of which involve underproduction of haemoglobin, the indispensable molecule in red blood cells that carries oxygen. The globin part of normal adult haemoglobin is made up of 2 alpha and 2 beta polypeptide chains. In beta thalassaemia, there is a mutation (change) in both beta globin chains leading to underproduction (or absence) of beta chains, underproduction of haemoglobin, and profound anaemia. The gene for beta thalassaemia is relatively frequent in people of mediterranean origin (for example, from italy and greece). Children with this disease inherit one gene for it from each parent (and so are said to be homozygous for beta thalassaemia). The parents are carriers (heterozygotes) with just one thalassaemia gene, are said to have thalassaemia minor, and are essentially normal. Their children affected with beta thalassaemia seem entirely normal at birth (because at birth we still have predominantly foetal haemoglobin which does not contain beta chains) but the anaemia emerges in the first few months of life and becomes progressively more severe leading to pallor and easy fatiguability, failure to thrive (grow), bouts of fever (due to infections) and diarrhoea. Treatment based on blood transfusions is helpful but not curative. Gene therapy will, it is hoped, be applicable to this disease. (12 Dec 1998) |
| absolute refractory period | The period following excitation when no response is possible regardless of the intensity of the stimulus. (05 Mar 2000) |
| refractory | Not readily yielding to treatment. Origin: L. Refractorius (18 Nov 1997) |
| refractory cast | A cast made of material that will withstand the high temperatures of metal casting or soldering without disintegrating. Synonym: investment cast. (05 Mar 2000) |
| refractory flask | A metal tube in which a refractory mold is made for casting metal dental restorations or appliances. Synonym: casting flask, casting ring. (05 Mar 2000) |
| refractory lining | A lining, usually of ceramic, capable of resisting and maintaining high temperatures. (05 Dec 1998) |
| refractory period | <neurology, physiology> most commonly used in reference to the interval (typically 1ms) after the passage of an action potential during which an axon is incapable of responding to another. This is caused by inactivation of the sodium channels after opening. The maximum frequency at which neurons can fire is thus limited to a few hundred Hertz. An analogous refractory period occurs in individuals of Dictyostelium discoideum, which are insensitive to extracellular cyclic AMP immediately after a pulse of cAMP has been secreted. The term can be applied to any system where a similar insensitive period follows stimulation. (18 Nov 1997) |
| refractory period of electronic pacemaker | The time required to restore full sensitivity after detecting cardiac activity or delivering a pacing impulse. (05 Mar 2000) |
| refractory period, psychological | A delayed response interval occurring when two stimuli are presented in close succession. (12 Dec 1998) |
| refractory rickets | Rickets that does not respond to treatment with usual doses of vitamin D and adequate dietary calcium and phosphorus. Most often due to inherited renal tubular disorder e.g., Fanconi syndrome. Renal rickets, a form of rickets occurring in children in association with and apparently caused by renal disease with hyperphosphatemia. Synonym: pseudorickets, renal fibrocystic osteosis, renal infantilism, renal osteitis fibrosa. (05 Mar 2000) |
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