| APV | Avian polyomavirus |
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| HaPV | Hamster polyomavirus |
| polyomavirus macacae | <virology> A species of polyomavirus isolated from rhesus monkey kidney tissue, which produces malignancy in human and newborn hamster kidney cell cultures and tumours on inoculation into newborn hamsters. (12 Dec 1998) |
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| antigens, polyomavirus transforming | Polyomavirus antigens which cause infection and cellular transformation. The large t antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle t antigen for the transformation of primary cells. Small t antigen is necessary for the completion of the productive infection cycle. (12 Dec 1998) |
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| polyomavirus | <virology> A papovavirus (genus Polyomavirus, family Papovaviridae) which is a DNA tumour virus with very small genome. Polyoma was isolated from mice, in which it causes no obvious disease, but when injected at high titre into baby rodents, including mice, it causes tumours of a wide variety of histological types (hence polyoma). In vitro, infected mouse cells are permissive for virus replication and thus are killed, whilst hamster cells undergo abortive infection and at a low frequency become transformed. It is capable of producing parotid tumours in mice and sarcomas in hamsters as well as tumours in other laboratory animals. Synonym: mouse parotid tumour virus. (22 Sep 2002) |
| polyomavirus hominis 1 | <virology> A species of polyomavirus apparently infecting over 90% of children but not clearly associated with any clinical illness in childhood. The virus remains latent in the body throughout life and can be reactivated under certain circumstances. (12 Dec 1998) |
| polyomavirus hominis 2 | <virology> A species of polyomavirus, originally isolated from the brain of a patient with progressive multifocal leukoencephalopathy. The patient's initials j.c. Gave the virus its name. Infection is not accompanied by any apparent illness but serious demyelinating disease can appear later, probably following reactivation of latent virus. (12 Dec 1998) |
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