| SSCP | single-stranded conformational polymorphism |
|---|---|
| SSC | single-strand conformational [analysis]; sister strand crossover; somatosensory cortex; standard sal... |
| IRDP | insulin-related DNA polymorphism |
| PIC | Personality Inventory for Children; polymorphism information content |
| RELP | restriction fragment length polymorphism |
| SSCP | PCR)-single stand conformational polymorphism |
|---|---|
| PCR-SSCP | Polymerase chain reaction single strand conformational polymorphism |
| SSCP | Single Strand Conformational Polymorphism |
| SSCP | Single Strand Conformational Polymorphism analysis |
| SSCP | Single Stranded Conformational Polymorphism |
| polymorphism, single-stranded conformational | Variation occurring within a species in the conformation of denatured DNA fragments. These single-stranded DNA fragments are allowed to partially renature in a way that prevents the formation of double-stranded DNA. The fragments are run on polyacrylamide gels under various conditions to detect subtle changes in migration due to altered secondary structure. The resulting bands will align themselves if the fragments are the same, but will misalign if any point mutations are present. Sscps have been used in detecting mutations in various genes, such as oncogenes, tumour suppressor genes, and genes responsible for genetic diseases. (12 Dec 1998) |
|---|
| single stranded conformational polymorphism | Technique for detecting point mutations in genes by amplifying a region of genomic DNA (using asymmetric PCR) and running the resulting product on a high quality gel. Single base substitutions can alter the secondary structure of the fragment in the gel, producing a visible shift in its mobility. (18 Nov 1997) |
|---|---|
| conformational change | <cell biology> Alteration in the shape usually the tertiary structure of a protein as a result of alteration in the environment pH, temperature, ionic strength) or the binding of a ligand (to a receptor) or binding of substrate (to an enzyme). (18 Nov 1997) |
| conformational map | A graphical representation in which the dihedral angle of rotation about the alpha-carbon to carbonyl-carbon bond in polypeptides is plotted against the dihedral angle of rotation about the alpha-carbon to nitrogen bond. Synonym: conformational map. (05 Mar 2000) |
| Haworth conformational formula | <biochemistry> Of cyclic sugars, for the pyranoses, these depict those shapes (conformations) on which none, one, or two ring-atoms lie outside the plane of the ring. If there are two such atoms para to each other, they can lie 1) on opposite sides of the plane (trans), giving chair forms, or 2) on the same side of the plane (cis), giving boat forms. For beta-d-ribopyranose, the two chair forms (4C1 and 1C4) are depicted. Similarly, there are six boat conformations. If the two (trans) exoplanar atoms are meta to each other, the conformation is a skew form; if the two atoms are ortho to each other, the conformation is a half-chair form. For the furanoses, the envelope conformations have one ring-atom exoplanar. If there are three adjacent, coplanar ring-atoms (the two exoplanar ring-atoms on opposite sides of the plane), the conformations are twist forms. (05 Mar 2000) |
| amplified fragment length polymorphism | <technique> Invented by KeyGene, a Dutch biotech company based in Wageningen, Holland. The technique is now merchandised under licence agreement by Perkin Elmer. Selected markers are amplified in a PCR, which makes amplified fragment length polymorphism an easy and fast tool for strain identification in agriculture, botany, microbiology and animal breeding. Acronym: AFLP (05 Feb 1998) |
| balanced polymorphism | <genetics> A type of polymorphism where the many morphs are alleles. The polymorphism is maintained in a population rather than the norm of one allele eventually becoming the only allele in the population, because individuals who are heterozygous, or have two different alleles, are more adaptive (more fit) than individuals who are homozygous, or have two copies of the same allele. (09 Oct 1997) |
| genetic polymorphism | The occurrence in the same population of multiple discrete alletic states of which at least two have high frequency (conventionally of 1% or more). (05 Mar 2000) |
| restriction fragment length polymorphism | <molecular biology, technique> A method that allows familial relationships to be established by comparing the characteristic polymorphic patterns that are obtained when certain regions of genomic DNA are amplified (typically by PCR) and cut with certain restriction enzymes. The variation in the length of DNA fragments produced by a restriction endonuclease that cuts at a polymorphic locus. Such variations are generated by mutations that create or abolish recognition sites for these enzymes. This is a key tool in DNA fingerprinting, reflecting the existence of different alleles in the individual. Restriction fragment length polymorphism mapping is also used in plant breeding to see if a key trait such as disease resistance is inherited. In principle, an individual can be identified unambiquously by restriction fragment length polymorphism hence the use of restriction fragment length polymorphism in forensic analysis of blood, hair or semen). Similarly, if a polymorphism can be identified close to the locus of a genetic defect, it provides a valuable marker for tracing the inheritance of the defect. Synonym: DNA fingerprinting. Acronym: RFLP (12 Jan 1998) |
| restriction length polymorphism | Fragment length polymorphism, the existence of allelic forms recognizable by the length of fragments that result when the nucleotide chain is treated by a specific restriction enzyme that cleaves wherever a particular sequence of nucleotides occurs. A mutation in this sequence changes cleaving and hence the number of fragments. (05 Mar 2000) |
| restriction-site polymorphism | DNA polymorphism in which the sequence of one form of the polymorphism contains a recognition site for a particular endonuclease, but the sequence of the other form lacks such a site. (05 Mar 2000) |
| corneal endothelial polymorphism | A greater than normal variation in the shape of the cells. (05 Mar 2000) |
| polymorphism | 1. <genetics> The regular and simultaneous occurrence in a single interbreeding population of two or more alleles of a gene, where the frequency of the rarer alleles is greater than can be explained by recurrent mutation alone (typically greater than 1%). The concept includes chromosome polymorphism. HLA alleles of the major histocompatibility complex are very polymorphic. 2. <zoology> The differentiation of various parts of the units of colonial animals into different types of unit specialised for different purposes, for example as in the colonial hydroid Obelia. (04 Jul 1999) |
| DNA polymorphism | A condition in which one of two different but normal nucleotide sequences can exist at a particular site in DNA. (05 Mar 2000) |
| lipoprotein polymorphism | Heritable variations in low density beta-lipoproteins; the variant lipoproteins exhibit different antigenic and chemical properties when compared with normal lipoproteins. (05 Mar 2000) |
Synonyms : Conformational Polymorphism, Single-Stranded, Conformational Polymorphisms, Single-Stranded, Polymorphism, Single Stranded Conformational, Polymorphisms, Single-Stranded Conformational, Single Stranded Conformational Polymorphism
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|