| FORTRAN | formula translation |
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| IVTT | in vitro transcription and translation |
| TIP | thermal inactivation point; Toxicology Information Program; translation-inhibiting protein; tumor-in... |
| eIF | Eukaryotic translation initiation factor |
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| eIF-2 | Eukaryotic translation initiation factor 2 |
| eIF3 | Eukaryotic translation initiation factor 3 |
| eIF-4E | Eukaryotic translation initiation factor 4E |
| eIF-5 | Eukaryotic translation initiation factor 5 |
| polarity of translation | Decrease in the synthesis of proteins specified by genes distal to the operator and to the site of a nonsense, frameshift, deletion or insertion mutation in an operon. A mutation which produces polarity is called a polar mutation or a polarity mutation. (12 Dec 1998) |
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| hybrid-arrested translation | <molecular biology> The prevention of an mRNA molecule from being translated into a protein by hybridising it to its corresponding cDNA or to a complementary mRNA. This is used to identify cDNA molecules - the scientist puts the cDNA molecule in question in a test tube with a number of mRNA molecules and observes which protein is no longer able to be made. (09 Oct 1997) |
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| nick translation | <molecular biology, technique> A technique used to radioactively label DNA. E. Coli DNA polymerase I will add a nucleotide, copying the complementary strand, to the free 3' OH group at a nick, at the same time its exonuclease activity removes the 5' terminus. The enzyme then adds a nucleotide at the new 3' OH and removes the new 5' terminus. In this way one strand of the DNA is replaced starting at a nick, which effectively moves along the strand. Nick translation refers to this translation or movement and not to protein synthesis. In practice, DNA is mixed with trace amounts of DNAase I to generate nicks, DNA polymerase I and labelled nucleotides. Because the nicks are generated randomly the DNA preparation can be uniformly labelled and to a high degree of specific activity. (10 Jan 1998) |
| translation | The process that occurs at the ribosome whereby the information in mRNA is used to specify the sequence of amino acids in a polypeptide chain. (18 Nov 1997) |
| translation, genetic | Formation of peptides on ribosomes, directed by messenger RNA. (12 Dec 1998) |
| cell polarity | 1. <cell biology> In epithelial cells the differentiation of apical and basal specialisations. In many epithelia the apical and baso lateral regions of plasma membrane differ in lipid and protein composition and are isolated from one another by tight junctions. The apical membrane may, for example: be the only region where secretory vesicles fuse or have a particular ionic pumping system. 2. A motile cell must have some internal polarity in order to move in one direction at a time: a region in which protrusion will occur (the front) must be defined. Locomotory polarity may be associated with the pericentriolar microtubule organising centre and can be perturbed by drugs that interfere with microtubule dynamics. (26 Mar 1998) |
| polarity | <physics> Literally having poles (like a magnet), but used to describe cells that have one or more axes of symmetry. <cell biology> In epithelial cells, the polarity meant is between apical and baso lateral regions, in moving cells, having a distinct front and rear. Some cells seem to show multiple axes of polarity (which will hinder forward movement). (18 Nov 1997) |
| segment polarity gene | <molecular biology> A segmentation gene, responsible for specifying anterior posterior polarity within individual embryonic segments. In Drosophila, there are at least 10 such genes, for example gooseberry. (18 Nov 1997) |
| neuronal polarity | Distribution of specific functions to discrete cellular domains: for example axons and dendrites that have different molecular composition, morphology and ultrastructure and perform different functions. (18 Nov 1997) |
| egg polarity gene | A gene whose product distribution in the egg determines the anterior posterior axis of subsequent development. Best characterised in Drosophila: See: bicoid, maternal effect gene. (18 Nov 1997) |
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