| PRPP | phosphoribosyl pyrophosphate |
|---|---|
| TEPP | tetraethyl pyrophosphate; triethylene pyrophosphate |
| APRT | adenine phosphoribosyl transferase |
| GARS | glycine amide phosphoribosyl synthetase |
| HGPRT | hypoxanthine guanine phosphoribosyl transferase |
| PRPP | 5'-Phosphoribosyl-1-pyrophosphate |
|---|---|
| PP-ribose-P | 5'phosphoribosyl-l-pyrophosphate |
| PPRibP | Phosphoribosyl pyrophosphate |
| PRPP | alpha-D-5--phosphoribosyl-1-pyrophosphate |
| CHO/HGPRT | Chinese hamster ovary cell hypoxanthine guanine phosphoribosyl transferase |
| phosphoribosyl pyrophosphate | <chemical> The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides. Chemical name: alpha-D-Ribofuranose, 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate) (12 Dec 1998) |
|---|
| hypoxanthine-guanine phosphoribosyl tranferase marker | The gene which codes for the enzyme hypoxanthine-guanine phosphoribosyl transferase. It is a selectable marker because cells which have a defective version of this gene are resistant to poisoning by toxic purine derivatives which result from the metabolic pathway that the HGPRT enzyme catalyses. (The purine derivatives are toxic because they incorporate into DNA as a result of the HGPRT enzyme's actions). Because the defective gene cannot produce the enzyme, no toxic purine derivatives are produced, the gene can therefore be selected for. (09 Oct 1997) |
|---|---|
| hypoxanthine-guanine phosphoribosyl transferase | <enzyme> An enzyme which plays an important role in the making of ATP and GTP from guanine -- the only way guanine, adenine, or other purine molecules are able to become part of nucleic acids. Biologists study gene action via the incorporation of modified nitrogenous bases into DNA by manipulating the metabolic role which this enzyme plays. Similarly, the enzyme thymidine kinase is used for the same purpose by biologists because it fills the same important and unique role for the pyrimidines (thymine, cytosine, uracil, etc.). Acronym: HGPRT (09 Oct 1997) |
| N-(5'-phosphoribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase | <enzyme> Has beta/alpha-barrel fold structure; involved in biosynthesis of histidine Registry number: EC 5.3.1.16 Synonym: hisa gene product, pfacr isomerase, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (26 Jun 1999) |
| alpha-hydroxyethylthiamin pyrophosphate | The activated form of acetaldehyde that is formed during the decarboxylation of active pyruvate. Formed in alcohol fermentation and in carbohydrate metabolism. Synonym: a-hydroxyethylthiamin pyrophosphate. (05 Mar 2000) |
| alpha-lactyl-thiamin pyrophosphate | An intermediate formed in the oxidative decarboxylation of pyruvate. Compare: pyruvate dehydrogenase (lipoamide). Synonym: alpha-lactyl-thiamin pyrophosphate. (05 Mar 2000) |
| aneurine pyrophosphate | The diphosphoric ester of thiamin, a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. Synonym: aneurine pyrophosphate, cocarboxylase, diphosphothiamin. (05 Mar 2000) |
| calcium pyrophosphate | <chemical> Diphosphoric acid, calcium salt. An inorganic pyrophosphate which affects calcium metabolism in mammals. Abnormalities in its metabolism occur in some human diseases, notably hypophosphatasia and pseudogout. Chemical name: Diphosphoric acid, calcium salt (12 Dec 1998) |
| calcium pyrophosphate deposition disease | <radiology> Manifestations can occur singly or in any combination, pseudogout, acute crystal-induced synovitis with clinical symptoms analogous to gout, arthropathy, beaklike osteophytes of 2nd, 3rd metacarpal heads, subchondral cysts (especially carpal bones), unusual distribution of disease (radiocarpal/ulnar joint, patellofemoral joint), SLAC - scapholunate advanced collapse, chondrocalcinosis, triangular fibrocartilage, symphysis pubis, menisci of knee, annulus fibrosus of intervertebral disk (12 Dec 1998) |
| geranylgeranyl pyrophosphate | A key intermediate in the biosynthesis of many terpenes. (05 Mar 2000) |
| geranyl pyrophosphate | A key intermediate in the biosynthesis of sterols, dolichols, ubiquinone, and prenylated proteins. (05 Mar 2000) |
| geranyl pyrophosphate-sabinene hydrate cyclase | <enzyme> Enzyme from sweet marjoram; catalyses cation-dependent cyclization of geranyl pyrophosphate to cis and trans sabinene hydrate, deriving oh from water, not from the pyrophosphate ester Registry number: EC 5.5.- Synonym: sabinene hydrate cyclase, sabinene hydrate synthase (26 Jun 1999) |
| prelycopersene pyrophosphate synthetase | <chemical> Synonym: prephytoene pyrophosphate synthetase, prephytoene synthase (26 Jun 1999) |
| prephytoene pyrophosphate dehydrogenase | <enzyme> Encoded by gene crte; reaction product of above enzyme is a phytoene; gene found in the cyanella (plastid) DNA of an eukaryotic alga, cyanophora paradoxa; amino acid sequence given in first source Registry number: EC 1.- Synonym: ppp-dehydrogenase, crte gene product, geranylgeranyl pyrophosphate synthase, geranylgeranyl-pyrophosphate synthase, albino-3 gene product (26 Jun 1999) |
| pyrophosphate | <chemistry> Two phosphate groups linked by esterification. Released in many of the synthetic steps involving nucleotide triphosphates (e.g. Protein and nucleic acid elongation). Rapid cleavage by enzymes that have high substrate affinity ensures that these reactions are essentially irreversible. (18 Nov 1997) |
| pyrophosphate-nucleoside kinase | <enzyme> From acholeplasma laidlawii; phosphorylates adenosine, inosine, and guanosine to the corresponding mononucleotides Registry number: EC 2.7.1.- Synonym: ppi dependent nucleoside kinase (26 Jun 1999) |
Synonyms : Pyrophosphate, Phosphoribosyl
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