| NPPase | nucleotide pyrophosphatase |
|---|---|
| PP | diphosphate group; emphysema [pink puffers]; near point of accommodation [Lat. punctum proximum]; pa... |
| TPPase | thiamine pyrophosphatase |
| APRT | adenine phosphoribosyl transferase |
| GARS | glycine amide phosphoribosyl synthetase |
| PPase | H(+)-pyrophosphatase |
|---|---|
| TPPase | Thiamin pyrophosphatase |
| PRPP | 5'-Phosphoribosyl-1-pyrophosphate |
| PP-ribose-P | 5'phosphoribosyl-l-pyrophosphate |
| CHO/HGPRT | Chinese hamster ovary cell hypoxanthine guanine phosphoribosyl transferase |
| phosphoribosyl pyrophosphate | <chemical> The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides. Chemical name: alpha-D-Ribofuranose, 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate) (12 Dec 1998) |
|---|---|
| hypoxanthine-guanine phosphoribosyl tranferase marker | The gene which codes for the enzyme hypoxanthine-guanine phosphoribosyl transferase. It is a selectable marker because cells which have a defective version of this gene are resistant to poisoning by toxic purine derivatives which result from the metabolic pathway that the HGPRT enzyme catalyses. (The purine derivatives are toxic because they incorporate into DNA as a result of the HGPRT enzyme's actions). Because the defective gene cannot produce the enzyme, no toxic purine derivatives are produced, the gene can therefore be selected for. (09 Oct 1997) |
| hypoxanthine-guanine phosphoribosyl transferase | <enzyme> An enzyme which plays an important role in the making of ATP and GTP from guanine -- the only way guanine, adenine, or other purine molecules are able to become part of nucleic acids. Biologists study gene action via the incorporation of modified nitrogenous bases into DNA by manipulating the metabolic role which this enzyme plays. Similarly, the enzyme thymidine kinase is used for the same purpose by biologists because it fills the same important and unique role for the pyrimidines (thymine, cytosine, uracil, etc.). Acronym: HGPRT (09 Oct 1997) |
| N-(5'-phosphoribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase | <enzyme> Has beta/alpha-barrel fold structure; involved in biosynthesis of histidine Registry number: EC 5.3.1.16 Synonym: hisa gene product, pfacr isomerase, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (26 Jun 1999) |
| guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase | <enzyme> Catalyses breakdown of guanosine tetraphosphate into guanosine diphosphate and pyrophosphate; spot protein is isolated from e. Coli Registry number: EC 3.1.7.2 Synonym: ppgpp-3'-pyrophosphohydrolase, guanosine tetraphosphate-3'-pyrophosphohydrolase, spot protein, spot gene product, ppgpp pyrophosphorylase, ppgppase, guanosine-5'-diphosphate 3'-diphosphate pyrophosphorylase (26 Jun 1999) |
| guanosine-5'-triphosphate, 3'-diphosphate pyrophosphatase | <enzyme> Catalyses the hydrolysis of guanosine 5'-triphosphate, 3'-diphosphate to yield guanosine 5'-diphosphate, 3'-diphosphate and orthophosphate; from E coli; also hydrolyzes other guanosine 5'-triphosphate derivatives with at least one unsubstituted phosphate group on the 3'-position, but not GTP, ATP or adenosine 5'-triphosphate, 3'-diphosphate Registry number: EC 3.6.1.40 Synonym: guanosine pentaphosphate phosphohydrolase, GTPdp pyrophosphatase, pppgpp 5'-phosphohydrolase, guanosine 5'-triphosphate-3'diphosphate 5'-phosphohydrolase, pppgpp-5'-phosphohydrolase, pppgpp-5'-phosphatase (26 Jun 1999) |
| pyrophosphatase | Any enzyme cleaving a pyrophosphate bond between two phosphoric groups, leaving one on each of the two fragments; e.g., inorganic pyrophosphatase, NAD+ p. (cleaves NAD, etc., to mononucleotides), ATP pyrophosphatase (cleaves inorganic pyrophosphate from ATP, leaving AMP). See: flavin adenine dinucleotide. (05 Mar 2000) |
| nucleoside-diphosphosugar pyrophosphatase | <enzyme> Catalyses the conversion of xdp-sugar to xmp and sugar 1-phosphate Registry number: EC 3.6.1.- Synonym: ndp-sugar pyrophosphatase, nucleotide-sugar pyrophosphatase (26 Jun 1999) |
| inorganic pyrophosphatase | A phosphohydrolase catalyzing hydrolysis of inorganic pyrophosphate to two orthophosphates. (05 Mar 2000) |
| oligosaccharide-diphosphodolichol pyrophosphatase | <enzyme> From yeast microsomal membranes; hydrolyses the pyrophosphate bond of oligosaccharide-pyrophosphodolichol into oligosaccharide phosphates plus dolicholphosphate Registry number: EC 3.6.1.44 Synonym: ols-pp-dol pyrophosphatase, oligosaccharide-pyrophosphodolichol pyrophosphatase (26 Jun 1999) |
| thiamine pyrophosphatase | <enzyme> The coenzyme form of vitamin B1 (thiamine), deficiency of which causes beri beri. Forms the prosthetic group of pyruvate dehydrogenase, _ ketoglutarate dehydrogenase and transketolase, in which it is involved in transfer of a 2 carbon unit. Marker for the trans cisternae of the Golgi complex. (18 Nov 1997) |
| FAD pyrophosphatase | <enzyme> Hydrolyzes fad to flavin mononucleotide and AMP Registry number: EC 3.6.1.18 Synonym: flavin-adenine dinucleotide phosphohydrolase, fad phosphohydrolase (26 Jun 1999) |
| UDPglucose pyrophosphatase | <enzyme> Acts on udpg to form uridine monophosphate and glucose-1-phosphate Registry number: EC 3.6.1.- (26 Jun 1999) |
| UDP glucuronate pyrophosphatase | <enzyme> Udpga is converted to ump plus glucuronic acid-1-phosphate Registry number: EC 3.6.1.- Synonym: udp-glucuronic acid pyrophosphatase (26 Jun 1999) |
| farnesyl pyrophosphatase | <enzyme> Catalyses conversion of farnesyl pyrophosphate to pyrophosphate and farnesol Registry number: EC 3.6.1.- Synonym: fppase (26 Jun 1999) |
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