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  • phosphodiesterase
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  • phosphodiesterase
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  • phosphodiester bond
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  • "3',5'-phosphodiester bond"
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PDE paroxysmal dyspnea on exertion; phosphodiester; progressive dialysis encephalopathy; pulsed Doppler ...
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PDE Phosphodiester
PO Phosphodiester
PD phosphodiester
CancerWEB ¿µ¿µ ÀÇÇлçÀü ¸ÂÃã °Ë»ö °á°ú : 8 ÆäÀÌÁö: 1
phosphodiester A diesterified orthophosphoric acid, RO-(PO2H)-OR', as in the nucleic acids.
(05 Mar 2000)
phosphodiester bond <chemistry> Not a precise term. Refers to any molecule in which two parts are joined through a phosphate group.
Examples are found in RNA, DNA, phospholipids, cyclic nucleotides, nucleotide diphosphates and triphosphates.
(18 Nov 1997)
phosphodiester hydrolases Enzymes (EC sub-subclass 3.1.4) cleaving phosphodiester bonds, such as those in cAMP or between nucleotides in nucleic acids, liberating smaller poly-or oligonucleotide units or mononucleotides but not inorganic phosphate.
Synonym: phosphodiester hydrolases.
(05 Mar 2000)
phosphodiester linkage <biochemistry> A chemical linkage in which two alcohols are esterically boundto a bridging molecule of phosphoric acid.
(31 Dec 1997)
phosphodiesterase <enzyme> An enzyme that cleaves phosphodiesters to give a phosphomonoester and a free hydroxyl group.
Examples include RNase, DNase, phospholipases C and D and the enzymes that convert cyclic nucleotides to the monoester forms. In casual usage the cAMP phosphodiesterase is usually meant.
(18 Nov 1997)
phosphodiesterase inhibitors Compounds which inhibit or antagonise the biosynthesis or actions of phosphodiesterases.
(12 Dec 1998)
phosphodiesterase-phosphomonoesterase <enzyme> From fusarium moniliforme; hydrolyzes both phosphodiesters and phosphomonoesters
Registry number: EC 3.1.-
Synonym: pdmase
(26 Jun 1999)
phosphodiesterases Enzymes (EC sub-subclass 3.1.4) cleaving phosphodiester bonds, such as those in cAMP or between nucleotides in nucleic acids, liberating smaller poly-or oligonucleotide units or mononucleotides but not inorganic phosphate.
Synonym: phosphodiester hydrolases.
(05 Mar 2000)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 2 ÆäÀÌÁö: 1
  • Phosphodiesterase I - »õâ A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis.
    Synonyms : 5'-Exonuclease, 5'-Nucleotidephosphodiesterase, Alkaline Phosphodiesterase, Alkaline Phosphodiesterase I, Oligonucleate 5'-Nucleotidohydrolase, Orthophosphoric Diester Phosphohydrolase, 5' Exonuclease, 5' Nucleotidephosphodiesterase
  • Phosphodiesterase Inhibitors - »õâ Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.
    Synonyms : Antiphosphodiesterases
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phosphodiesterase (PDE). An enzyme that hydrolyzes cAMP into AMP.
Ãâó: www.nature.com/nrd/journal/v2/n4/glossary/nrd1061_...
phosphodiester bond A bond between a two sugar groups and a phosphate group; such bonds form the sugar-phosphate-sugar backbone of DNA and RNA. A diester bond (between phosphoric acid and two sugar molecules) linking two nucleotides together to form the nucleotide polymers DNA and RNA.
Ãâó: helios.bto.ed.ac.uk/bto/glossary/p.htm
phosphodiester a diester of phosphoric acid.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
phosphodiesterase i. any of a class of drugs that inhibit the activity of phosphodiesterases, each agent having a different effect because of differing affinities for the various phosphodiesterase fractions; the class includes amrinone, dipyridamole, enoximone, milrinone, papaverine, and theophylline.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
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