| SDT | sensory detection theory; right sacrotransverse [fetal position] [Lat. sacrodextra transversa]; sign... |
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| SIN | salpingitis isthmica nodosa |
| MAD | Major Antigenic Determinant |
| AD | accident dispensary; acetate dialysis; active disease; acute dermatomyositis; addict, addiction; ade... |
| NAD | neutrophil actin dysfunction; new antigenic determinant; nicotinamide adenine dinucleotide; nicotini... |
| MAP | Multiple Antigenic Peptide |
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| VAT | variant antigenic type |
| SIN-1 | 3-Morpholino-sydnonimine |
| DFT | Density Functional Theory |
| IRT | Item Response Theory |
| sin | 1. Transgression of the law of God; disobedience of the divine command; any violation of God's will, either in purpose or conduct; moral deficiency in the character; iniquity; as, sins of omission and sins of commission. "Whosoever committeth sin is the servant of sin." (John viii. 34) "Sin is the transgression of the law." (1 John III. 4) "I think 't no sin. To cozen him that would unjustly win." (Shak) "Enthralled By sin to foul, exorbitant desires." (Milton) 2. An offense, in general; a violation of propriety; a misdemeanor; as, a sin against good manners. "I grant that poetry's a crying sin." (Pope) 3. A sin offering; a sacrifice for sin. "He hath made him to be sin for us, who knew no sin." (2 Cor. V. 21) 4. An embodiment of sin; a very wicked person. "Thy ambition, Thou scarlet sin, robbed this bewailing land Of noble Buckingham." (Shak) Sin is used in the formation of some compound words of obvious signification; as, sin-born; sin-bred, sin-oppressed, sin-polluted, and the like. Actual sin, Canonical sins, Original sin, Venial sin. See Actual, Canonical, etc. Deadly, or Mortal, sins, willful and deliberate transgressions, which take away divine grace; in distinction from vental sins. The seven deadly sins are pride, covetousness, lust, wrath, gluttony, envy, and sloth. Sin eater, a man who (according to a former practice in England) for a small gratuity ate a piece of bread laid on the chest of a dead person, whereby he was supposed to have taken the sins of the dead person upon himself. Sin offering, a sacrifice for sin; something offered as an expiation for sin. Synonym: Iniquity, wickedness, wrong. See Crime. Origin: OE. Sinne, AS. Synn, syn; akin to D. Zonde, OS. Sundia, OHG. Sunta, G. Sunde, Icel, Dan. & Sw. Synd, L. Sons, sontis, guilty, perhaps originally from the p. Pr. Of the verb signifying, to be, and meaning, the one who it is. Cf. Authentic, Sooth. Source: Websters Dictionary (01 Mar 1998) |
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| sin recombinase | <enzyme> From staphylococcus aureus; genbank l23109; do not confuse with sin gene product, a repressor protein from bacillus subtilis Registry number: EC 2.7.7.- Synonym: sin gene product, staphylococcus (26 Jun 1999) |
| original | 1. Pertaining to the origin or beginning; preceding all others; first in order; primitive; primary; pristine; as, the original state of man; the original laws of a country; the original inventor of a process. "His form had yet not lost All her original brightness." (Milton) 2. Not copied, imitated, or translated; new; fresh; genuine; as, an original thought; an original process; the original text of Scripture. 3. Having the power to suggest new thoughts or combinations of thought; inventive; as, an original genius. 4. Before unused or unknown; new; as, a book full of original matter. Original sin, the first sin of Adam, as related to its consequences to his descendants of the human race; called also total depravity. See Calvinism. Origin: F. Original, L. Originalis. 1. Origin; commencement; source. "It hath it original from much grief." (Shak) "And spangled heavens, a shining frame, Their great Original proclaim." (Addison) 2. That which precedes all others of its class; archetype; first copy; hence, an original work of art, manuscript, text, and the like, as distinguished from a copy, translation, etc. "The Scriptures may be now read in their own original." (Milton) 3. An original thinker or writer; an originator. "Men who are bad at copying, yet are good originals." (C. G. Leland) 4. A person of marked eccentricity. 5. <zoology> The natural or wild species from which a domesticated or cultivated variety has been derived; as, the wolf is thought by some to be the original of the dog, the blackthorn the original of the plum. Origin: Cf. F. Original. Source: Websters Dictionary (01 Mar 1998) |
| Theiler's original virus | A virus in the family Picornaviridae. Synonym: Theiler's original virus, Theiler's virus. (05 Mar 2000) |
| Koch's original tuberculin | <protein> A protein extracted from the tuberculosis bacteriumMycobacterium tuberculosis. It is used in tests to determine if aperson has been exposed to the bacteria and is in danger of coming down with the disease. (09 Oct 1997) |
| antigenic | Having the properties of an antigen (allergen). Synonym: allergenic, immunogenic. (05 Mar 2000) |
| antigenic competition | Competition that occurs when two different antigens, each of which can evoke an immunological response when inoculated alone, are mixed in equal quantities and inoculated together; the response may be to only one, that to the other being largely or entirely suppressed. (05 Mar 2000) |
| antigenic complex | A composite of different antigenic structures, such as a cell or a bacterium, or, by extension, a molecule containing two or more determinant groups of different antigenic specificities. (05 Mar 2000) |
| antigenic determinant | That part of an antigenic molecule against which a particular immune response is directed. For instance a tetra to penta peptide sequence in a protein, a tri to penta glycoside sequence in a polysaccharide. In the animal most antigens will present several or even many antigenic determinants simultaneously. See: hapten. (18 Nov 1997) |
| antigenic drift | <immunology> A change that occurs on the molecular level to effect a change in the antigenicity of a bacteria or virus. Antigenic drift occurs naturally and more rapidly in certain viruses (for example HIV). It is antigenic drift which complicates the development of an effective HIV (AIDS) vaccine. (27 Sep 1997) |
| antigenic modulation | Loss of detectable antigen from the surface of a cell after incubation with antibodies. This is one method in which some tumours escape detection by the immune system. Antigenic modulation of target antigens also reduces the therapeutic effectiveness of treatment by monoclonal antibodies. (12 Dec 1998) |
| antigenic shift | Mutation, i.e., sudden change in molecular structure of RNA/DNA in microorganisms, especially viruses, which produces new strains of the microorganism; hosts previously exposed to other strains have little or no acquired immunity to the new strain; antigenic shift is believed to be the explanation for the occurrence of strains of microorganisms, such as the influenza virus, associated with large scale epidemics. (05 Mar 2000) |
| antigenic switching | <immunology> The process by which a pathogenic microbe's genetic structure is altered tochange its surface antigens inorder to avoid being detected by the host's immune system. (09 Oct 1997) |
| antigenic variation | The phenomenon of changes in surface antigens in parasitic populations of Trypanosoma and Plasmodium (and some other parasitic protozoa) in order to escape immunological defense mechanisms. at least 100 different surface proteins have been found to appear and disappear during antigenic variation in a clone of trypanosomes. Each antigen is encoded in a separate gene. Antigenic variation is also known to occur in free living Protozoa and certain bacteria. (18 Nov 1997) |
| idiotypic antigenic determinant | The antigenic specificites defined by the unique sequences (idiotopes) of the antigen combining site. Thus anti-idiotype antibodies combine with those specific sequences, may block immunological reactions and may resemble the epitope to which the first antibody reacts. (18 Nov 1997) |
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