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OR Oestrogen receptor
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oestrogen <endocrinology, hormone> A generic term for oestrus producing steroid compounds, the female sex hormones.
In humans, oestrogen is formed in the ovary, possibly the adrenal cortex, the testis and the foetoplacental unit, it has various functions in both sexes. It is responsible for the development of the female secondary sex characteristics and during the menstrual cycle it acts on the female genitalia to produce an environment suitable for the fertilization, implantation and nutrition of the early embryo.
Oestrogen is used in oral contraceptives and as a palliative in cancer of the breast after menopause and cancer of the prostate, other uses include the relief of the discomforts of menopause, inhibition of lactation and treatment of osteoporosis, threatened abortion and various functional ovarian disorders.
(18 Nov 1997)
oestrogen antagonist <pharmacology> A drug or compound which inhibit or antagonise the action or biosynthesis of oestrogen.
Tamoxifen also has agonist or stimulatory actions as well as blocking effects. There are also selective oestrogen-receptor modulators (SERMs). For example, raloxifene (trade name Evista) is classified as a SERM because it prevents bone loss (like oestrogen) and lowers serum cholesterol (like oestrogen) but (unlike oestrogen) does not stimulate the endometrial lining of the uterus.
(12 May 2002)
oestrogen receptor <cell biology> Cytoplasmic proteins that bind oestrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of oestrogen receptors in breast cancer patients has become clinically important and determines the likelihood of response to anti-oestrogen therapy with tamoxifen.
(17 Jul 2002)
oestrogen replacement therapy <endocrinology, gynaecology> The use of oestrogenic substances in postmenopausal or other oestrogen-deficient women to alleviate effects of hormone deficiency, such as vasomotor symptoms, dyspareunia, and progressive development of osteoporosis.
(12 Dec 1998)
oestrogenic 1. Causing estrus in animals.
2. Having an action similar to that of an oestrogen.
(05 Mar 2000)
oestrogenic hormone <pharmacology> A female hormone produced by the ovaries (or an equivalent hormone synthesised in the laboratory). Oestrogen deficiency can lead to osteoporosis.
(12 Dec 1998)
oestrogenism <veterinary> A mycotoxic disease of pigs associated with eating moldy feeds containing the fungus Fusarium graminearum; the causative toxin is zeralenone, which produces a form of vulvovaginitis.
(05 Mar 2000)
oestrogens A class of sex hormones associated with the development and maintenance of secondary female sex characteristics and control of the cyclical changes in the reproductive cycle. They are also required for pregnancy maintenance and have an anabolic effect on protein metabolism and water retention.
(12 Dec 1998)
oestrogens, catechol 2- or 4-hydroxyoestrogens. Substances that are physiologically active in mammals, especially in the control of gonadotropin secretion. Physiological activity can be ascribed to either an oestrogenic action or interaction with the catecholaminergic system.
(12 Dec 1998)
oestrogens, conjugated An amorphous preparation containing water-soluble, conjugated forms of mixed oestrogens obtained from urine of pregnant mares. The principal oestrogen present is sodium estrone sulfate. The total oestrogenic potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate.
(12 Dec 1998)
oestrogens, synthetic Compounds obtained by chemical synthesis which possess oestrogenic activity, but differ in structure from naturally occurring oestrogens.
(12 Dec 1998)
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catechol oestrogen Any 2-hydroxylated derivative of an oestrogen; they, with their methylated derivatives, can account for up to one-half of all excreted oestrogen metabolites.
(05 Mar 2000)
conjugated oestrogen <pharmacology> An amorphous preparation of naturally occurring, water-soluble, conjugated forms of mixed oestrogen's obtained from the urine of pregnant mares; the principal oestrogen present is sodium estrone sulfate; suitable for parenteral, oral, and topical administration, and used in conditions responsive to oestrogen therapy.
(05 Mar 2000)
selective oestrogen-receptor modulator <pharmacology> An antioestrogen which possesses some, but not all, of the actions of oestrogen. For example, raloxifene (evista) is classified as a SERM because it prevents bone loss (like oestrogen) and lowers serum cholesterol (like oestrogen) but (unlike oestrogen) does not stimulate the endometrial lining of the uterus.
Acronym: SERM
(17 Jul 2002)
designer oestrogen An engineered drug that possesses some, but not all, of the actions of oestrogen. Designer oestrogens are selective oestrogen-receptor modulators (SERMs). For example, raloxifene (trade name Evista) is classified as a SERM because it prevents bone loss (like oestrogen) and lowers serum cholesterol (like oestrogen) but (unlike oestrogen) does not stimulate the endometrial lining of the uterus.
(12 Dec 1998)
testosterone-oestrogen-binding globulin A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Changes in its concentration significantly affect the ratio of unbound (biologically active) testosterone to estradiol in plasma.
(12 Dec 1998)
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oestrogen estrogen: a general term for female steroid sex hormones that are secreted by the ovary and responsible for typical female sexual characteristics
Ãâó: wordnet.princeton.edu/perl/webwn
oestrogen The generic term for a group of female sex hormones which control the development of sexual characteristics and control oestrus.
Ãâó: www.fao.org/docrep/003/X3910E/X3910E18.htm
oestrogen Hormone which stimulates the function of the female reproductive organs.
Ãâó: www.bdid.com/termso.htm
oestrogen A hormone, produced mainly by the ovaries, responsible for female sexual development and female secondary sex characteristics. Increasing oestrogen levels in the follicular phase (pre-ovulatory phase) of the cycle stimulates significant changes in the cervix, cervical mucus, and the endometrium.
Ãâó: www.fertilityuk.org/nfps02.html
oestrogen This hormone causes the breast tenderness and enlargement which are typical of early pregnancy. It is produced throughout pregnancy, and helps to regulate levels of progesterone and prepare the womb for the baby and the breasts for feeding.
Ãâó: www.hon.ch/Dossier/MotherChild/preg_changes/hormon...
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oestrogen a general term for female steroid sex hormones that are secreted by the ovary and responsible for typical female sexual characteristics
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