| OCA | oculocutaneous albinism; olivopontocerebellar atrophy; oral contraceptive agent |
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| RM | radical mastectomy; random migration; radon monitor; range of movement; red marrow; reference materi... |
| OCA | Oculocutaneous albinism |
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| PAM | Primary acquired melanosis |
| albinism, oculocutaneous | Heterogeneous group of autosomal recessive disorders comprising at least four recognised types, all having in common varying degrees of hypopigmentation of the skin, hair, and eyes. The two most common are the tyrosinase-positive and tyrosinase-negative types. (12 Dec 1998) |
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| cephalo-oculocutaneous telangiectasia | An angioma involving the skin of the face, orbit, meninges, and brain. See: Sturge-Weber syndrome. (05 Mar 2000) |
| oculocutaneous | Relating to the eyes and the skin. (05 Mar 2000) |
| oculocutaneous albinism | An autosomal recessive deficiency of pigment in skin, hair, and eyes; in the tyrosinase negative type, there is an absence of tyrosinase; in the tyrosinase positive type, there is normal tyrosinase which cannot enter pigment cells; it is transmitted by an autosomal recessive inheritance. The compound heterozygote is normal so the two forms are not allelic. There are several types: type IA is characterised by absence of tyrosinase with life-long complete absence of melanin, marked photophobia, and nystagmus. Type IB, yellow albinism with low or absent tyrosinase; improves with age. Type II, with normal tyrosinase activity is the most common; hair darkens and nevi and freckles develop. Type III is characterised by absent tyrosinase but pigmentation of the iris in the first decade. Type IV in Africans with normal tyrosinase. Type V with red hair. Type VI, Hermansky-Padlak syndrome, with haemorrhage due to platelet deficiency and low to absent tyrosinase. Synonym: Hermansky-Pudlak syndrome type VI. (05 Mar 2000) |
| oculocutaneous syndrome | <syndrome> Bilateral uveitis with iritis and glaucoma, premature graying of the hair, and alopecia, vitiligo, and dysacusia; related to Harada's syndrome and sympathetic ophthalmia. Synonym: oculocutaneous syndrome, uveocutaneous syndrome. Origin: Cecile and Oscar Vogt (05 Mar 2000) |
| melanosis | A disorder caused by a disturbance in melanin pigmentation, melanism. (18 Nov 1997) |
| melanosis circumscripta precancerosa | An obsolete term for lentigo maligna. (05 Mar 2000) |
| melanosis coli | Melanosis of the large intestinal mucosa due to accumulation of pigment of uncertain composition within macrophages in the lamina propria. (05 Mar 2000) |
| melanosis corii degenerativa | A congenital abnormality in which pigment is deposited in whorls and streaks; vesicles occasionally occur, and it may be associated with cardiac or neurologic disorders. Compare: incontinentia pigmenti, incontinentia pigmenti achromians. (05 Mar 2000) |
| Riehl's melanosis | A brown pigmentary condition of the exposed portions of the skin of the neck and face with melanin pigment in dermal macrophages, thought to result from photodermatitis due to materials, such as cosmetic ingredients, or oils encountered in various occupations. (05 Mar 2000) |
| precancerous melanosis of Dubreuilh | An obsolete term for lentigo maligna. (05 Mar 2000) |
| neurocutaneous melanosis | Cutaneous giant pigmented nevi associated with melanosis of the leptomeninges; malignant melanomas may develop in the skin or meninges. (05 Mar 2000) |
| oculodermal melanosis | Pigmentation of the conjunctiva and skin around the eye, usually unilateral; seen especially in women of Oriental races. Synonym: Ota's nevus. (05 Mar 2000) |
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