| DST | 1) Donor Specific Transfusion 2) Dexamethasone Suppression Test |
|---|---|
| CAST | calpastatin; Cardiac Arrhythmia Suppression Trial; Children of Alcoholism Screening Test |
| DST | desensitization test; dexamethasone suppression test; dihydrostreptomycin; disproportionate septal t... |
| HTS | head traumatic syndrome; HeLa tumor suppression; human thyroid-stimulating hormone, human thyroid st... |
| PST | pancreatic suppression test; paroxysmal supraventricular tachycardia; penicillin, streptomycin, and ... |
| NST | Nonsense Syllable Test |
|---|---|
| NMD | Nonsense-mediated mRNA decay |
| CAST | Cardiac Arrhythmia Suppression Trial |
| CISS | Chromosomal in situ suppression |
| CSD | Conditioned Suppression of Drinking |
| nonsense suppression | Mutant tRNAs that read a chain termination codon as the signal for incorporation of a specific amino acid residue. (05 Mar 2000) |
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| codon, nonsense | A codon that is not assigned to an amino acid or to any stop signal. It was originally thought that nonsense codons were synonymous with terminator codons (codon, terminator) in that they signaled termination of a protein chain. Recent studies have found this not to be true. (12 Dec 1998) |
|---|---|
| nonsense | As used in genetics, relating to a mutation that causes a sequence such that the growing peptide chain terminates, often after several incorrect amino acid residues are incorporated. (05 Mar 2000) |
| nonsense codon | <molecular biology> The three codons, UAA (known as ochre), UAG (amber) and UGA (opal), that do not code for an amino acid but act as signals for the termination of protein synthesis. Any mutation that causes a base change which produces a nonsense codon results in premature termination of protein synthesis and probably a nonfunctional or nonsense protein. (13 Nov 1997) |
| nonsense mutation | <molecular biology> A mutation that causes a polypeptide chain to be ended prematurely. (13 Nov 1997) |
| nonsense strand | <molecular biology> DNA that does not code for part of a polypeptide chain or RNA.This includes introns and pseudo genes. In eukaryotes the majority of the DNA is noncoding. Noncoding strand refers to the so called nonsense strand, as opposed to the sense strand which is actually translated into mRNA. (18 Nov 1997) |
| nonsense syndrome | <syndrome> A psychotic-like condition, without the symptoms and signs of a traditional psychosis, occurring typically in prisoners who feign insanity; e.g., such a person, when asked to multiply 6 by 4, will give 23 as the answer, or he will call a key a lock. See: malingering, factitious disorder. Synonym: nonsense syndrome, syndrome of approximate relevant answers, syndrome of deviously relevant answers. (05 Mar 2000) |
| nonsense triplet | A trinucleotide (codon) in which a base change to a termination codon results in premature termination of the growing polypeptide chain and, consequently, incomplete protein molecules, a termination codon. (05 Mar 2000) |
| ACTH suppression test | <investigation> A test that measures the response of the adrenal glands to ACTH. In this case, dexamethasone is given to the patient and then blood cortisol levels are measured. Under normal conditions, cortisol levels should drop in response to dexamethasone. In this test one milligram of dexamethasone is administered in the morning and then the blood is drawn for analysis the following morning. Abnormal test results can indicate Cushing's syndrome. (27 Sep 1997) |
| bone marrow suppression | <oncology, pharmacology> A side effect of many anticancer and antiviral drugs, including AZT. Bone marrow suppression leads to a decrease in white blood cells, red blood cells and platelets. Such reductions in turn result in anaemia, bacterial infections and spontaneous or excess bleeding. (09 Oct 1997) |
| growth hormone suppression test | <investigation> A test to determine if growth hormone is suppressed by hyperglycaemia. Growth hormone blood levels are determined sequentially after ingestion of a glucose-rich meal. If growth hormone levels remain elevated (after the glucose is given) then acromegaly or gigantism is suspected. (27 Sep 1997) |
| cortisol suppression test | <investigation> A test that measures the response of the adrenal glands to ACTH. In this case, dexamethasone is given to the patient and then blood cortisol levels are measured. Under normal conditions, cortisol levels should drop in response to dexamethasone. In this test one milligram of dexamethasone is administered in the morning and then the blood is drawn for analysis the following morning. Abnormal test results can indicate Cushing's syndrome. (27 Sep 1997) |
| suppression | 1. The act of suppressing, or the state of being suppressed; repression; as, the suppression of a riot, insurrection, or tumult; the suppression of truth, of reports, of evidence, and the like. 2. <medicine> Complete stoppage of a natural secretion or excretion; as, suppression of urine; used in contradiction to retention, which signifies that the secretion or excretion is retained without expulsion. 3. Omission; as, the suppression of a word. Synonym: Overthrow, destruction, concealment, repression, detention, retention, obstruction. Origin: L. Suppressio: cf. F. Suppression. Source: Websters Dictionary (01 Mar 1998) |
| suppression amblyopia | The suppression of the central vision in one eye when the images from the two eyes are so different that they cannot be fused into one. This may be due to: 1) faulty image formation (sensory amblyopia); 2) a large difference in refraction between the two eyes (anisometropic amblyopia); or 3) the two eyes pointing in different directions (strabismic amblyopia). Most suppression amblyopia can be reversed if appropriately treated before age 6 years. Synonym: amblyopia ex anopsia. (05 Mar 2000) |
| suppression, genetic | The restoration of the wild-type phenotype in an organism possessing a mutationally altered genotype. The effects of the mutation may be suppressed by a second "suppressor" mutation on a different gene, by a suppressor mutation on the same gene but located at a distance from the site of the primary mutation, or by the presence of a cytoplasmic suppressor due to a change in non-chromosomal DNA. (12 Dec 1998) |
| dexamethasone suppression test | <endocrinology, investigation> A test that measures the response of the adrenal glands to ACTH. Dexamethasone is given to the patient and then blood cortisol levels are measured. Under normal conditions, cortisol levels should drop in response to dexamethasone. In this test one milligram of dexamethasone is administered in the morning and then the blood is drawn for analysis the following morning. Abnormal test results can indicate Cushing's syndrome. (27 Sep 1997) |
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