| NFD | neurofibrillary degeneration |
|---|---|
| NFT | neurofibrillary tangle |
| CRD | carbohydrate-recognition domain; chronic renal disease; chronic respiratory disease; child restraint... |
| RD | radial deviation; radiology department; rate difference; Raynaud disease; reaction of degeneration; ... |
| SCD | scleroderma; service-connected disability; sickle-cell disease; spinocerebellar degeneration; subacu... |
| NFD | Neurofibrillary degeneration |
|---|---|
| NFT | Neurofibrillary Tangles |
| ARMD | AGE-RELATED MACULAR DEGENERATION |
| AMD | Age related macular degeneration |
| CBD | Cortico-basal degeneration |
| neurofibrillary degeneration | Formation of coarse, argentophilic, intracytoplasmic fibres, often in complex tangles within intracranial nerve cells that are undergoing aging. See: Alzheimer's disease. (05 Mar 2000) |
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| neurofibrillary tangle | <cell biology> Accumulation of twisted protein fragments inside nerve cells. Neurofibrillary tangles are one of the characteristic structural abnormalities found in the brains of patients with Alzheimer's disease patients. Upon autopsy, the presence of neuritic plaquesand neurofibrillary tangles is used to positively diagnose Alzheimer's disease. (22 May 1997) |
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| neurofibrillary tangles | Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: 1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; 2) the microtubule-associated proteins map-2 and tau; 3) actin; and 4) ubiquitin. As one of the hallmarks of alzheimer disease, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brainstem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of alzheimer disease. (12 Dec 1998) |
| adipose degeneration | Abnormal formation of microscopically visible droplets of fat in the cytoplasm of cells, as a result of injury. Synonym: adipose degeneration, steatosis. (05 Mar 2000) |
| adiposogenital degeneration | A disorder characterised primarily by obesity and hypogonadotrophic hypogonadism in adolescent boys; dwarfism is rare, and when present is thought to reflect hypothyroidism. Visual loss, behavioural abnormalities, and diabetes insipidus may occur. Frohlich's syndrome often is used synonymously for this disorder, although the original case involved a pituitary tumour; most cases are thought to result from hypothalamic dysfunction in areas regulating appetite and gonadal development. The most common causes are pituitary and hypothalamic neoplasms. Synonym: adiposis orchica, adiposogenital degeneration, adiposogenital dystrophy, adiposogenital syndrome, hypophysial syndrome, hypothalamic obesity with hypogonadism. Origin: L. Fr. G. Dys-, bad, + trophe, nourishment (05 Mar 2000) |
| age-related macular degeneration | A common macular degeneration beginning with drusen of the macula and pigment disruption and sometimes leading to severe loss of central vision. (05 Mar 2000) |
| albuminous degeneration | An obsolete terms for cloudy swelling. (05 Mar 2000) |
| amyloid degeneration | Infiltration of amyloid between cells and fibres of tissues and organs. Synonym: waxy degeneration. (05 Mar 2000) |
| angiolithic degeneration | Calcareous degeneration of the walls of the blood vessels. (05 Mar 2000) |
| ascending degeneration | Retrograde degeneration of an injured nerve fibre; i.e., toward the nerve cell of the fibre, degeneration cephalad to a spinal cord lesion. (05 Mar 2000) |
| atheromatous degeneration | Focal accumulation of lipid material (atheroma) in the intima and subintimal portion of arteries, eventually resulting in fibrous thickening or calcification. (05 Mar 2000) |
| axonal degeneration | A type of peripheral nerve fibre response to insult, wherein axon death and subsequent breakdown occurs, with secondary breakdown of the myelin sheath associated; caused by focal injury to peripheral nerve fibres; often referred to as wallerian degeneration. Synonym: axon degeneration. (05 Mar 2000) |
| axon degeneration | A type of peripheral nerve fibre response to insult, wherein axon death and subsequent breakdown occurs, with secondary breakdown of the myelin sheath associated; caused by focal injury to peripheral nerve fibres; often referred to as wallerian degeneration. Synonym: axon degeneration. (05 Mar 2000) |
| ballooning degeneration | A phenomenon observed especially in cells that are infected with certain viruses, resulting in conspicuous swelling of the cell and cytoplasmic vacuolation. (05 Mar 2000) |
| basophilic degeneration | Blue staining of connective tissues when haematoxylin-eosin stain is used; found in such conditions as solar elastosis. (05 Mar 2000) |
| calcareous degeneration | In a precise sense, not a degenerative process per se, but the deposition of insoluble calcium salts in tissue that has degenerated and become necrotic, as in dystrophic calcification. (05 Mar 2000) |
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