| 영문 | myosin | 한글 | 굵은근육미세섬유, 미오신 |
|---|---|---|---|
| 설명 | 골격근 근육섬유 속의 근육원섬유는 굵은 잔섬유와 가는 잔섬유로 이루어지는데, 미오신은 굵은 잔섬유를 구성하는 근단백질의 40% 이상을 차지하는 글로불린 모양의 단백질이다. 거의 불용성에 가까운 젤을 형성하기 때문에 근육의 수축과 이완에 중요한 역할을 한다. 1942년에 센트죄르지가 발견하였다. 굵은 잔섬유는 직경 1~12nm, 길이 1.6μm로, 미오신분자가 중합되어 만들어졌으며, 두 개의 팽창된 머리부분을 갖고 있다. 근절(sarcomere: 근원섬유 중의 섬유 방향의 반복단위)의 굵은 잔섬유는 200~400개의 미오신 분자로 이루어져 있다. 분자량 50만, 길이 160nm, 지름 2nm의 성냥개비 모양의 구조이다. 분자량 21만 5000인 폴리펩티드 두개와 몇 개의 저분자량 단백질로 되어 있는데, 이것들이 올바르게 짝지어져야 비로소 생물활성이 나타나게 된다. |
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| 영문 | light reflex | 한글 | 빛반사 |
|---|---|---|---|
| 설명 | 1. 한쪽 눈에 빛을 비추면, 이 빛은 시각신경에 의해 뇌에 전달되고, 이 자극은 사람의 의지와 무관하게 곧, 눈돌림신경으로 전달되어 양쪽 눈의 동공이 축소하게 된다. 이런 모든 일련의 과정을 빛반사라 부르는데 이것은 사람이 어두운 곳에 가거나 어두운 곳에서 갑자기 밝은 곳에 나갔을 때, 동공이 반사적으로 움직이는 것과 같은 것이다. 2. 고막에서 반사하는 광상. 3. 망막경의 거울로 망막에서 반사하는 고리모양의 많은 점. |
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| VL | variable domain of the light chain; variable light chain |
|---|---|
| MLC | minimum lethal concentration; mixed leukocyte culture; mixed ligand chelate; mixed lymphocyte concen... |
| MLCK | myosin light chain kinase |
| MLCP | myosin light-chain phosphatase |
| MYL | light chain myosin |
| MLCK | Myosin Light Chain Kinase |
|---|---|
| MLC | Myosin light chain |
| MLC2 | Myosin light chain 2 |
| MLCP | Myosin light chain phosphatase |
| MLC-1 | Myosin light chain-1 |
| myosin light chain | <protein> The light chains of the muscle protein myosin. Each molecule of myosin is composed of two heavy chains and two pairs of light chains. The light chains have a molecular weight of about 20 kD and there is one dissimilar pair of light chains associated with each heavy chain. The proteins all have sequence homology to calmodulin, but not all with calcium binding activity. Several types are known: regulatory light chains (LC 2, DNTB light chains) probably regulate the ATPase activity of the heavy chain directly (through the binding of calcium) or indirectly (activating when they themselves are phosphorylated by myosin light chain kinase) and essential light chains (LC 1, LC 3, alkali light chains), which have a more subtle and apparently nonessential role. In molluscan muscle the EDTA light chains (similar to LC 2 from vertebrate muscle) confer calcium sensitivity on the myosin itself. The light chains are "calmodulin-like" proteins that bind calcium. Two of them can be removed easily, and two with difficulty. The light chains bind the heavy chains in the vicinity of the head groups of the myosin. (12 Dec 1998) |
|---|---|
| myosin light chain kinase | <enzyme> An enzyme that phosphorylates myosin light chains in the presence of ATP to yield myosin-light chain phosphate and ADP, and requires calcium and calmodulin. The 20-kD light chain is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors. The enzyme plays a central role in the regulation of smooth muscle contraction. Chemical name: ATP:myosin-light-chain O-phosphotransferase Registry number: EC 2.7.1.117 (12 Dec 1998) |
| myosin heavy chain | <protein> See myosin: do not confuse with heavy meromyosin which is a subfragment of the heavy chain of myosin II. (18 Nov 1997) |
|---|---|
| gene rearrangement, b-lymphocyte, light chain | Ordered rearrangement of b-lymphocyte variable gene regions coding for the kappa or lambda light chains, thereby contributing to antibody diversity. It occurs during the second stage of differentiation of the immature b-lymphocyte. (12 Dec 1998) |
| P light chain | <protein> Myosin light chain that can be phosphorylated by myosin light chain kinase, as a result of phosphorylation, the myosin is activated. (18 Nov 1997) |
| immunoglobulins, light-chain | Polypeptide chains, consisting of 211 to 217 amino acid residues, isolated from immunoglobulins and having a molecular weight of approximately 22 kD. There are two major types of light chains, kappa and lambda. In man they are found in a ratio of 60% to 40%, respectively. Both chains consist of linear repeating, similar, but not identical, segments of about 110 amino acid residues. In each segment a disulfide bond establishes a tightly folded approximately 60-membered loop or domain. Adjacent domains are linked by less tightly folded regions. Both light chains contain two such domains. Two light and two heavy chains make one immunoglobulin molecule, but both light chains in one ig are of the same type. (12 Dec 1998) |
| EDTA light chain | <protein> Myosin light chains (18 kD) from scallop muscle (two per pair of heavy chains), easily extracted by calcium chelation. Although the EDTA light chains do not bind calcium they confer calcium sensitivity on the myosin heavy chains. (18 Nov 1997) |
| light chain | <immunology, protein> The lighter of the two types of polypeptide chains that are found in immunoglobulin and antibody molecules. Also used as a non-specific term for the smaller subunits of several multimeric proteins such as immunoglobulin, myosin, dynein, clathrin. (14 Oct 1997) |
| light chain-related amyloidosis | A form of primary amyloidosis in which the fibrillar amyloid deposits are derived from the amino terminal variable region of the light chains of immunoglobulin; seen in B-lymphocyte and plasma-cells dyscrasias. (05 Mar 2000) |
| chain, orthodontic chain | <dentistry> A stretchable plastic chain used to hold archwires into brackets and to moke teeth. (08 Jan 1998) |
| myosin | <protein> A family of motor ATPases that interact with F actin filaments. An increasing number of different myosins are being described. (See myosin light chains, meromyosin.) Myosin I is a low molecular weight (111-128 kD) form found in protozoa Acanthamoeba and Dictyostelium) that does not self assemble and is found in the cytoplasm as a globular monomeric molecule that can associate with membranes and transport membrane vesicles along microfilaments. Brush border Myosin I is a single headed myosin found in the microvilli of vertebrate intestinal epithelial cells, linking the membrane to the microfilament core. There is a single heavy chain of 119 kD and multiple (3 or 4) calmodulin light chains. The heavy chain has a C terminal domain that binds to acidic phospholipids. Myosin II is the classical sarcomeric myosin that self assembles into bipolar thick filaments. Myosin II is a multimeric protein (440 kD) with two heavy chains (200 kD) and two pairs of light chains (17-22 kD) in each hexamer. Between species and tissues there are considerable variations in the properties of Myosin II (see myosin light chains, meromyosin). Cytoplasmic myosin II is a family of sarcomeric myosin like proteins, also hexameric, responsible for force generation by interaction with microfilaments. There are two heavy chains (up to 240 kD) and two pairs of light chains (15-20 kD), the self assembled filaments are shorter than those of the sarcomere. The MYO2 gene product is an unconventional myosin from yeast involved in polarized secretion. MYO2 may be similar to dilute myosin from mouse and p190 protein from vertebrate brain. Scallop myosin is directly calcium regulated (through regulatory and essential light chains) and is more similar to sarcomeric myosin than to the nonsarcomeric myosins. Smooth muscle myosin has two 200 kD heavy chains, two regulatory 20 kD light chains that can be phosphorylated, altering its binding to the heavy chains which induces a conformational change that renders the myosin active and two 17 kD light chains. (18 Nov 1997) |
| myosin atpase | <enzyme> An enzyme that catalyses the hydrolysis of myosin ATP in the presence of actin to form myosin ADP and orthophosphate. This reaction is the immediate source of free energy that drives muscle contraction. In the absence of actin, myosin atpase activity is low and requires calcium ions. Chemical name: Myosin ATP phosphohydrolase (actin-translocating) Registry number: EC 3.6.1.32 (12 Dec 1998) |
| myosin filament | One of the contractile elements in skeletal, cardiac, and smooth muscle fibres; in skeletal muscle, the filament is about 10 nm thick and 1.5 um long. (05 Mar 2000) |
| myosin heavy chains | The heavy chains of the muscle protein myosin. Each molecule of myosin is composed of two heavy chains and two pairs of light chains. The heavy chains have a molecular weight of about 230 kD and each heavy chain is associated with a dissimilar pair of light chains. (devlin, textbook of biochemistry: with clinical correlations, 3rd ed, p957) (12 Dec 1998) |
| myosin subfragments | Parts of the myosin molecule resulting from cleavage by proteolytic enzymes (papain, trypsin, or chymotrypsin) at well-localised regions. Study of these isolated fragments helps to delineate the functional roles of different parts of myosin. Two of the most common subfragments are myosin s-1 and myosin s-2. S-1 contains the heads of the heavy chains plus the light chains and s-2 contains part of the double-stranded, alpha-helical, heavy chain tail (myosin rod). (12 Dec 1998) |
| subfragment 1 of myosin | See: S1. (18 Nov 1997) |
| alternating light test | Test to detect a relative afferent defect in one eye by watching pupillary movements. With the patient fixing in the distance, the light is held on each eye for about a second, and quickly moved to the other eye. Assuming no defect of the innervation to the iris sphincter in one eye (which would produce an anisocoria in light), the eye with the weaker light response has a relative afferent pupillary defect. This asymmetry of pupillomotor input can be estimated by holding neutral density filters in front of the better eye until the pupillary responses of the two eyes are balanced. Synonym: swinging light test. (05 Mar 2000) |
Synonyms : Myosin Alkali Light Chain, Myosin Essential Light Chain, Myosin Essential Light Chains, Myosin Light Chain, Myosin Regulatory Light Chain, Myosin Regulatory Light Chains, Light Chain, Myosin, Light Chains, Myosin
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|