| AMbL | acute myeloblastic leukemia |
|---|---|
| AML | acute monocytic leukemia; acute mucosal lesion; acute myeloblastic leukemia; acute myelocytic leukem... |
| AMLSGA | acute myeloblastic leukemia surface glycoprotein antigen |
| Mbps | megabits per second; myeloblastic syndrome |
| AL | absolute latency; acinar lumen; acute leukemia; adaptation level; albumin; alcoholism [and other dru... |
| AML | Acute Myeloblastic Leukaemia |
|---|---|
| AML | Acute myeloblastic |
| ALV | Avian Leukosis Virus |
| BLV | Bovine leukosis virus |
| LL | Lymphoid Leukosis |
| acute myeloblastic leukaemia | <haematology> A rapidly progressing cancer of the blood affecting immature cells of the bone marrow, usually of the white cell population. It is much more common in adults than in children. Symptoms include fatigue, weight loss, fevers, weakness, pallor, bone pains, bleeding gums, nosebleeds, easy bruising, enlarged lymph nodes and joint pains. Treatment includes chemotherapy and/or bone marrow transplant. This leukaemia demonstrates granulocyte differentiation, eosinophilia and Auer rods and is associated with a reciprocal translocation between 8 and 21 (q22;q22), which is the most common translocation in acute myeloid leukaemia and is found more often in younger patients than in older patients. The oncogene involved in this translocation is AML1, which can be detected by Southern blot. Numerical abnormalities, particularly monosomy-7, trisomy-4, trisomy-8, trisomy-21, -Y, monosomy-7 and deletions of the long arms of chromosomes 5 and 7 are quite common in all acute myeloid leukaemia and not restricted to any one FAB classification. Many of these abnormalities are observed at diagnosis and at later stage disease, particularly after chemotherapy. Prognosis is generally more favorable than in FAB-M2 patients showing no translocation, because the latter patients show better remission rates for longer periods of time. Immunophenotyping is useful in diagnosis and expression of one or more of the myeloid antigens CD13, CD14 or CD33 must be detected to make a diagnosis of acute myeloid leukaemia. Acronym: AML Incidence: 2,000 new cases per year in the UK. Origin: Gr. Haima = blood (07 Apr 1998) |
|---|---|
| myeloblastic | <haematology> Immature cells of the myeloid series. (13 Nov 1997) |
| myeloblastic leukaemia | A form of granulocytic leukaemia in which there are large numbers of myeloblasts in various tissues (and organs) and in the circulating blood; the immature forms may amount to 30 to 60% (or even a greater proportion) of the increased total number of white blood cells. Used synonymously for acute granulocytic leukaemia. Synonym: leukaemic myelosis. (05 Mar 2000) |
| myeloblastic protein | See: human leukaemia-associated antigens. (05 Mar 2000) |
| avian leukosis | A group of transmissible, virus-induced diseases of chickens, characterised by proliferation of immature erythroid, myeloid, or lymphoid cells. It includes both leukaemic and solid-tumour forms. (12 Dec 1998) |
| avian leukosis-sarcoma virus | avian leukosis-sarcoma complex |
| bovine leukosis virus | A type C retrovirus in the subfamily Retrovirinae, commonly infecting cattle, especially dairy cows; in a small proportion of infected cattle, it will cause enzootic bovine leukosis. Synonym: bovine leukosis virus. (05 Mar 2000) |
| sporadic bovine leukosis | A rare disease of cattle less than 3 years of age, of unknown cause, characterised by the development of lymphosarcoma; three clinicopathological forms are recognised: calf or juvenile form, thymic form, and cutaneous form. (05 Mar 2000) |
| enzootic bovine leukosis | A lymphoid neoplastic disease in cattle caused by the bovine leukaemia virus. Enzootic bovine leukosis may take the form of lymphosarcoma, malignant lymphoma, or leukaemia but the presence of malignant cells in the blood is not a consistent finding. (12 Dec 1998) |
| fowl leukosis | A group of transmissible, virus-induced diseases of chickens, characterised by proliferation of immature erythroid, myeloid, or lymphoid cells. It includes both leukaemic and solid-tumour forms. (12 Dec 1998) |
| leukosis virus, avian | The type species of avian type c retroviruses (retroviruses type c, avian) producing latent or manifest lymphoid leukosis in fowl. (12 Dec 1998) |
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