| CMM | cell-mediated mutagenesis; cutaneous malignant melanoma |
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| MMM | see 3-M [syndrome]; microsome-mediated mutagenesis; myelofibrosis with myeloid metaplasia; myeloscle... |
| STM | Signature-tagged mutagenesis |
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| SDM | Site-directed mutagenesis |
| mutagenesis | The development of mutations. (09 Oct 1997) |
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| mutagenesis, insertional | Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA can be inserted into or adjacent to a cellular proto-oncogene. Insertion of the provirus can cause mutations by interrupting coding sequences or regulatory elements, or cause unregulated expression of the proto-oncogene resulting in tumour formation. (12 Dec 1998) |
| mutagenesis, site-directed | Mutagenesis where the mutation is caused by in vitro induction directed at a specific site in a DNA molecule. The most common method involves use of a chemically synthesised oligonucleotide mutant which can hybridise with the DNA target molecule. The resulting mismatch-carrying DNA duplex may then be transfected into a bacterial cell line and the mutant strands recovered. (12 Dec 1998) |
| cassette mutagenesis | The production of mutants within a region (often bounded by unique restriction sites) by the use of synthetic oligonucleotides that fill the gap with mutants designed into the synthetic genetic material. (05 Mar 2000) |
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| site-directed mutagenesis | <molecular biology> Any of several methods used to create specific alterations in a gene. (09 Oct 1997) |
| site-specific mutagenesis | <cell culture, molecular biology> An in vitro technique in which an alteration is made at a specific site in a DNA molecule, which is then reintroduced into a cell. Various techniques are used, for the cell biologist, a very powerful approach to determining which parts of a protein or nucleotide sequence are critical to function. (18 Nov 1997) |
| insertional mutagenesis | Generally, mutagenesis of DNA by the insertion of one or more bases. Specific examples: 1. Oncogenesis by insertion of a retrovirus adjacent to a cellular proto-oncogene. 2. A strategy of mutagenesis with transposons. After a round of transposition, progeny are screened by PCR, with transposon and gene specific primers, for the proximity of the transposon sequence to the gene of interest. As PCR can only produce products up to 1-2 kb, a large fraction of progeny identified as positive by PCR will have a transposon close enough to the gene to inactivate or otherwise alter its pattern of expression. (18 Nov 1997) |
| transposon mutagenesis | <molecular biology> Insertion of a transposon into a gene, this inactivates the host gene leading to a mutant phenotype and also confers the phenotype associated with the transposon gene. (09 Oct 1997) |
Synonyms : Mutageneses
Synonyms : Activation, Insertional, Activations, Insertional, Cassette Mutageneses, Cassette Mutagenesis, Insertional Activations, Insertional Mutageneses, Insertional Mutageneses, Viral, Insertional Mutagenesis, Viral, Linker Insertion Mutagenesis, Mutageneses, Cassette
Synonyms : Mutageneses, Oligonucleotide-Directed, Mutageneses, Site-Directed, Mutageneses, Site-Specific, Mutagenesis, Oligonucleotide Directed, Mutagenesis, Site Directed, Mutagenesis, Site Specific, Oligonucleotide Directed Mutagenesis, Site Directed Mutagenesis
| mutagenesis |
an event capable of causing a mutation
Ãâó: wordnet.princeton.edu/perl/webwn
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| mutagenesis |
Mutations are permanent, sometimes transmissible (if the change is to a germ cell) changes to the genetic material (usually DNA or RNA) of a cell. Mutations can be caused by copying errors in the genetic material during cell division and by exposure to radiation, chemicals, or viruses, or can occur deliberately under cellular control during the processes such as meiosis or hypermutation. ...
Ãâó: en.wikipedia.org/wiki/Mutagenesis
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| mutagenesis |
Change(s) in the genetic constitution of a cell through alterations to its DNA.
Ãâó: www.fao.org/docrep/003/X3910E/X3910E16.htm
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| mutagenesis |
Process by which mutations occur.
Ãâó: science.education.nih.gov/supplements/nih1/cancer/...
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| mutagenesis |
Production of mutations; this may lead to transformation and carcinogenesis. See carcinogenesis, transformation.
Ãâó: www.bio.hw.ac.uk/edintox/glossall.htm
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| mutagenesis | an event capable of causing a mutation |
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