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  • multidrug resistance
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  • multidrug resistance gene family
KMLE ÀÇÇоà¾î »çÀü À¯»ç °Ë»ö °á°ú : 3 ÆäÀÌÁö: 1
MDR median duration of response; medical device reporting; minimum daily requirement; multidrug resistan...
MDR TB multidrug-resistant tuberculosis
MRP mean resisting potential; medical reimbursement plan; multidrug resistance-associated protein
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MRP Multidrug Resistance Protein
MRP1 Multidrug Resistance Protein 1
MRP Multidrug Resistance associated Protein
MDR 1 Multidrug Resistance gene
MRP(1) Multidrug Resistance-Associated protein
CancerWEB ¿µ¿µ ÀÇÇлçÀü ¸ÂÃã °Ë»ö °á°ú : 2 ÆäÀÌÁö: 1
multidrug resistance The insensitivity of various tumours to a variety of chemically related anticancer drugs; mediated by a process of inactivating the drug or removing it from the target tumour cells.
(05 Mar 2000)
multidrug transporter Closely related family (ABC transporters) of integral membrane glycoproteins that export a variety of solutes from the cytoplasm.
(18 Nov 1997)
CancerWEB ¿µ¿µ ÀÇÇлçÀü À¯»ç °Ë»ö °á°ú : 1 ÆäÀÌÁö: 1
tuberculosis, multidrug-resistant Tuberculosis resistant to chemotherapy with two or more antitubercular agents. The problem of resistance is particularly troublesome in tuberculosis as an opportunistic disease in HIV infection.
(12 Dec 1998)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 1 ÆäÀÌÁö: 1
  • Multidrug Resistance-Associated Proteins - »õâ A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.
    Synonyms : ATP-Binding Cassette, Sub-Family C Proteins, MOAT Protein, Multispecific Organic Anion Transport Proteins, Multispecific Organic Anion Transporter, ATP Binding Cassette, Sub Family C Proteins, Multidrug Resistance Associated Protein
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multidrug resistance Adaptation of tumor cells to anticancer drugs in ways that make the drugs less effective.
Ãâó: www.stjude.org/glossary
multidrug resistance Adaptation of tumor cells to chemotherapy by eliminating the drugs faster or breaking them down so that they are no longer effective.
Ãâó: nydailynews.healthology.com/nydailynews/15836.htm
multidrug resistance A characteristic of cells that makes them resistant to the effects of several different classes of drugs. There are several forms of drug resistance.They each are determined by genes that govern how the cell will respond to the chemical agents. One type of multidrug resistance (or MDR) involves the ability to eject several drugs out of cells. The cell outer wall or membrane of the cell contains a pump that ejects chemicals, preventing them from reaching a toxic concentration. ...
Ãâó: cll.ucsd.edu/glossarym.htm
multidrug resistance resistance of tumor cells to several unrelated drugs after exposure to a single chemotherapy drug.
Ãâó: www.cancer.org/docroot/GRY/GRY_0.asp
multidrug resistance Resistance of tumors or infectious agents to a wide-range of therapeutic compounds. In cancer multidrug resistance ABC-MDR proteins actively expel the cytotoxic drugs from cells, maintaining the drug level below a cell-killing threshold. Drug extrusion mediated by these primary active transporters is driven by the energy of ATP hydrolysis. The most intriguing characteristic distinguishing the ABC-MDR proteins from other mammalian transporters is their wide substrate specificity. ...
Ãâó: www.solvo.hu/glossary.html
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