| H0 | null hypothesis |
|---|---|
| H1 | alternative hypothesis |
| LNH | large number hypothesis |
| TRH | tension-reducing hypothesis; thyrotropin-releasing hormone |
| MAbs | Monoclonal Antibodies |
| (3)H | hypothesis that |
|---|---|
| BMG | benign monoclonal gammopathy |
| Bi-MAbs | Bispecific monoclonal antibodies |
| BsMab | Bispecific monoclonal antibody |
| HuMAbs | Human monoclonal antibodies |
| antibodies, monoclonal | Antibodies produced by clones of cells such as those isolated after hybridization of activated b lymphocytes with neoplastic cells. These hybrids are often referred to as hybridomas. (12 Dec 1998) |
|---|---|
| monoclonal | 1. <cell biology> Used of a cell line whether within the body or in culture to indicate that it has a single clonal origin. 2. <immunology> Monoclonal antibodies are produced by a single clone of hybridoma cells and are therefore a single species of antibody molecule. (18 Nov 1997) |
| monoclonal antibodies | Identical antibodies that are made in large amounts in the laboratory. Doctors are studying ways of using monoclonal antibodies to treat leukaemia. (12 Dec 1998) |
| monoclonal antibody | <immunology, molecular biology> A substance, usually a protein, which can be synthsised in the laboratory in pure form by a single clone (population) of cells. These antibodies can be made in large quantities and have a specific affinity for certain target molecules called antigens which can be found on the surface of cells and those that are malignant. Monoclonal antibodies are currently being investigated as a possible form of cancer treatment although their benefit has not be fully proven. (16 Dec 1997) |
| monoclonal gammopathies, benign | Conditions characterised by the presence of a monoclonal serum (or urine) protein without clinical manifestations of plasma cell dyscrasia. (12 Dec 1998) |
| monoclonal immunoglobulin | A homogenous immunoglobulin resulting from the proliferation of a single clone of plasma cells and which, during electrophoresis of serum, appears as a narrow band or "spike"; it is characterised by heavy chains of a single class and subclass, and light chains of a single type. Synonym: M protein, monoclonal protein, paraprotein. (05 Mar 2000) |
| monoclonal peak | A narrow band visible on electrophoresis or an abnormal arc seen on immunoelectrophoresis, thought to represent immunoglobulin of one cell clone. (05 Mar 2000) |
| monoclonal protein | A homogenous immunoglobulin resulting from the proliferation of a single clone of plasma cells and which, during electrophoresis of serum, appears as a narrow band or "spike"; it is characterised by heavy chains of a single class and subclass, and light chains of a single type. Synonym: M protein, monoclonal protein, paraprotein. (05 Mar 2000) |
| adaptor hypothesis | A hypothesis, proposed by F.H.C. Crick, that an adaptor molecule must be present between the information-containing DNA and the protein being synthesised. (05 Mar 2000) |
| altered self hypothesis | The hypothesis that the T-cell receptor in MHC mediated phenomena recognises a syngeneic MHC Class I or Class II molecule after modification by a virus or certain chemicals. See: MHC restriction. (18 Nov 1997) |
| alternative hypothesis | In Neyman-Pearson testing of a hypothesis, the hypothesis or family of hypotheses about the numerical value of a parameter if and only if the null hypothesis is rejected as untenable. (05 Mar 2000) |
| autocrine hypothesis | That tumour cells containing viral oncogenes may have encoded a growth factor, normally produced by other cell types, and thereby produce the factor autonomously, leading to uncontrolled proliferation. (05 Mar 2000) |
| Avogadro's hypothesis | <physics> The hypothesis that equal volumes of two different gases at the same temperature and pressure contain the same number of molecules. (02 Jan 1998) |
| Bayesian hypothesis | An array of surmised values of a parameter to be severally explored in the light of a current set of data, with logical symmetry being preserved among all. The merits of each hypothesis entertained are based on quantity, the prior probability. The probability of the data conditional on the hypothesis is computed as the conditional probability for each; the product of the two for each hypothesis is the joint probability, and the ratio of each joint probability to the sum of all the joint probabilities is the posterior probability for that hypothesis. Unlike the Neyman-Pearson test of hypotheses, the answer is a statement about the hypothesis, not about the sample conditional on the hypothesis. No hypothesis is preferred or prevails by default. The procedure may be applied recursively any number of times, as the data becomes available. (05 Mar 2000) |
| Makeham's hypothesis | A development of Gompertz' hypothesis as to the force of mortality following some mathematical law. Makeham assumed that death was the consequence of two generally coexisting causes: 1) chance; 2) a deterioration or increased inability to withstand destruction. The first of these is constant, the second is an increasing geometrical progression. (05 Mar 2000) |
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