| DHFR | DiHydroFolate Reductase |
|---|---|
| ADR | activation, depression, repetition [in bone remodeling]; adrenodoxin reductase; Adriamycin; adverse ... |
| ALDR | aldose reductase |
| ALR | aldehyde reductase |
| AR | absolute risk; accounts receivable; achievement ratio; actinic reticuloid [syndrome]; active resista... |
| HMG-CoA reductase | 3-Hydroxy-3-methylglutaryl CoA reductase |
|---|---|
| HMG-CoA reductase | 3-Hydroxy-3-methylglutaryl coenzyme A reductase |
| MTHFR | 10-Methylenetetrahydrofolate reductase |
| HMGR | 3-Hydroxy-3-methylglutaryl CoA reductase |
| HMGR | 3-Hydroxy-3-methylglutaryl coenzyme A reductase |
| metyrapone reductase | <enzyme> From mouse liver microsomes, belongs to the family of carbonyl reductases; can use NADH or NADPH as co-substrates Registry number: EC 1.1.1.- (26 Jun 1999) |
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| metyrapone | <chemical> Chemical name: 1-Propanone, 2-methyl-1,2-di-3-pyridinyl- (12 Dec 1998) |
|---|---|
| metyrapone test | <endocrinology, investigation> This test measures the ability of the pituitary gland to secrete ACTH in response to a low serum cortisol level. Under normal conditions a low serum cortisol level should stimulate the pituitary to produce ACTH, which stimulates the adrenal glands to produce more cortisol. This test is performed by injecting metyrapone into the bloodstream and then measuring cortisol levels over a period of time. Metyrapone is a substance which inhibits an enzyme (steroid 11-beta hydroxylase) involved in the synthesis of cortisol. This enzyme normally converts 11-deoxycortisol to cortisol. When the enzyme is inhibited, 11-deoxycortisol levels will increase in the blood and urine and cortisol levels will go down. This test is useful in differentiating the different forms of Cushing's syndrome: adrenal hyperplasia versus primary adrenal tumour. Those with an adrenal tumour (or carcinoma) generally have no response to metyrapone injection, since the dose is insufficient to inhibit cortisol synthesis. (27 Sep 1997) |
| acetoacetyl-CoA reductase | An oxidoreductase catalyzing interconversion of a 3-oxoacyl-CoA and NADPH, and the corresponding d-3-hydroxyacyl-CoA, and NADP+. A step in fatty acid synthesis. (05 Mar 2000) |
| acetohexamide reductase | <enzyme> Catalyses the conversion of acetohexamide to (-)-hydroxyhexamide Registry number: EC 1.1.1.- (26 Jun 1999) |
| acryloyl-CoA reductase | <enzyme> Clostridium kluyveri enzyme; contains fmn, ferredoxin, and flavodoxin; can act as electron donors Registry number: EC 1.3.99.- Synonym: acryloyo-coenzyme a reductase (26 Jun 1999) |
| aflatoxin B1 aldehyde reductase | <enzyme> Catalyses the conversion of the dialdehydic form of aflatoxin b1-dihydrodiol to the dialcohol form Registry number: EC 1.1.1.- Synonym: aflatoxin b1-aldehyde reductase, afb1-ar (26 Jun 1999) |
| aflatoxin B1 reductase | <enzyme> Reduces the cyclopentenone ring of aflatoxin b1 to aflatoxicol; requires NADPH as cofactor Registry number: EC 1.1.1.- (26 Jun 1999) |
| aflatoxin G2a reductase | <enzyme> Has broad substrate specificity in cell-free extracts from aspergillus parasiticus; versicolorin a hemiacetal is reduced to versicolorin c; 17-hydroxy-16,17-dihydrosterigmatocystin is reduced to a 14,17-hydrated derivative; aflatoxin g2a is converted to a 13,16-hydrated derivative of afg2 Registry number: EC 1.1.1.- (26 Jun 1999) |
| aldehyde reductase | <enzyme> An enzyme that catalyses reversibly the oxidation of an aldose to an alditol. It possesses broad specificity for many aldoses. Chemical name: Alditol:NAD(P)+ 1-oxidoreductase Registry number: EC 1.1.1.21 (12 Dec 1998) |
| aldose reductase | A polyol dehydrogenase (NADP+);an oxidoreductase that reversibly converts aldoses to alditols (e.g., glucose to sorbitol) with NADPH as hydrogen donor. An important step in the metabolism of sorbitol and in the formation of diabetic cataracts. See: d-sorbitol-6-phosphate dehydrogenase. (05 Mar 2000) |
| aldose reductase inhibitor | <pharmacology> A class of drugs being studied as a way to prevent eye and nerve damage in people with diabetes. Aldose reductase is an enzyme that is normally present in the eye and in many other parts of the body. It helps change glucose (sugar) into a sugar alcohol called sorbitol. Too much sorbitol trapped in eye and nerve cells can damage these cells, leading to retinopathy and neuropathy. Drugs that prevent or slow (inhibit) the action of aldose reductase are being studied as a way to prevent or delay these complications of diabetes. (09 Oct 1997) |
| alkyl hydroperoxide reductase | <enzyme> Reduces an alkyl hydroperoxide to the corresponding alcohol in the presence of NADPH; ahpc gene product from salmonella typhimurium Registry number: EC 1.- Synonym: ahpc gene product, alkylhydroperoxide reductase, ahpf gene product (26 Jun 1999) |
| alpha,beta-ketoalkene reductase | <enzyme> Nadh is much less effective than NADPH; catalyses the reduction of the carbon-carbon double bond of five membered ring cpds which have two conjugated carbonyl groups on both sides of a double bond Registry number: EC 1.3.1.- Synonym: n-ethylmaleimide reducing enzyme, NADPH-linked alpha,beta-ketoalkene double bond reductase, n-ethylmaleimide reductase (26 Jun 1999) |
| alpha-santonin-1,2-reductase | <enzyme> From pseudomonas cichorii s.; catalyses the reduction of the 1,2-double bond of santonin; NADH or NADPH dependent Registry number: EC 1.3.1.- Synonym: santonin 1,2-reductase (26 Jun 1999) |
| amine tetrazolium reductase | <enzyme> Tetrazolium salts as hydrogen acceptors Registry number: EC 1.4.- Synonym: tryptamine dehydrogenase, monoamine tetrazolium reductase, monoamine dehydrogenase (26 Jun 1999) |
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