| mRNP | messenger ribonucleoprotein |
|---|---|
| snRNP | small nuclear ribonucleoprotein particle |
| mRNA | messenger Ribo-Nucleic Acid |
| H-mRNA | H-chain messenger ribonucleic acid |
| mRNA | messenger ribonucleic acid |
| mRNP | messenger ribonucleoprotein particle |
|---|---|
| mRNP | Messenger ribonucleoprotein |
| RNP | Ribonucleoprotein particle |
| snRNP | small nuclear ribonucleoprotein particle |
| mRNA | E-messenger RNA |
| ribonucleoprotein | <protein> Complexes of RNA and protein involved in a wide range of cellular processes. Besides ribosomes (with which ribonucleoprotein was originally almost synonymous), in eukaryotic cells both initial RNA transcripts in the nucleus (hnRNA) and cytoplasmic mRNAs exist as complexes with specific sets of proteins. Processing (splicing) of the former is carried out by small nuclear ribonucleoproteins (snRNP). Other examples are the signal recognition particle responsible for targetting proteins to endoplasmic reticulum and a complex involved in termination of transcription. Acronym: RNP (23 Aug 1998) |
|---|---|
| masked messenger RNA | <molecular biology> Long lived and stable mRNA found originally in the oocytes of echinoderms and constituting a store of maternal information for protein synthesis that is unmasked (derepressed) during the early stages of morphogenesis. In these early stages the rate of cell division is so rapid that transcription from the embryonic genome cannot occur. Undoubtedly not restricted to oocytes and the term can be applied to any mRNA which is present in inactive form. (18 Nov 1997) |
| messenger | 1. That which carries a message. 2. Having message-carrying properties. First messenger, a hormone that binds to a receptor on the surface cell and, in so doing, communicates with intracellular metabolic processes. Second messenger, an intermediary molecule that is generated as a consequence of hormone-receptor interaction; e.g., see adenosine 3',5'-cyclic monophosphate; guanosine 3',5'-cyclic monophosphate; calcium; inositide. (05 Mar 2000) |
| messenger-like RNA | An ill-defined form of RNA, of high molecular weight, that never leaves the nucleus and is thought to be the precursor of messenger RNA. (05 Mar 2000) |
| messenger RNA | <molecular biology> Single stranded RNA molecule that specifies the amino acid sequence of one or more polypeptide chains. This information is translated during protein synthesis when ribosomes bind to the mRNA. In prokaryotes, mRNA is normally formed by splicing a large primary transcript from a DNA sequence and protein synthesis starts while the mRNA is still being synthesised. Prokaryote mRNAs are usually very short lived (average t 1/2 is 5mins.). In contrast, in eukaryotes the primary transcripts (HnRNA) are synthesised in the nucleus and they are extensively processed to give the mRNA that is exported to the cytoplasm where protein synthesis takes place. This processing includes the addition of a 5' 5' linked 7 methyl guanylate cap at the 5' end and a sequence of adenylate groups at the 3' end, the poly A tail, as well as the removal of any introns and the splicing together of exons, only 10% of HnRNA leaves the nucleus. Eukaryote mRNAs are comparatively long lived with a half life ranging from 30minutes to 24 hours. (27 Jun 1999) |
| second messenger | <molecular biology> In many hormone sensitive systems the systemic hormone does not enter the target cell but binds to a receptor and indirectly affects the production of another molecule within the cell, this diffuses intracellularly to the target enzymes or intracellular receptor to produce the response. This intracellular mediator is called the second messenger. Examples include cyclic AMP, cyclic GMP, IP3 and diacylglycerol. (18 Nov 1997) |
| second messenger systems | Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a hormone or neurotransmitter. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-cyclic AMP system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the cyclic GMP system. (12 Dec 1998) |
| alpha particle | <physics> A radioactive particle made up of two protons and two neutrons, these particles are created by the decay of a radioactive material or by nuclear bombardment, and they are the same as the nucleus of a helium-4 atom. (09 Oct 1997) |
| beta particle | <physics, radiobiology> An electron or positron emitted from a radioactive nucleus during beta decay. (09 Oct 1997) |
| genes, intracisternal a-particle | A family of retrovirus-like genetic elements coding for virus-like particles found regularly in early rodent embryos (2-cell to blastocyst stage), but which, under certain circumstances such as DNA hypomethylation, are transcribed in a wide variety of neoplasms, including plasmacytomas, neuroblastomas, rhabdomyosarcomas, teratocarcinomas, and colon carcinomas. (12 Dec 1998) |
| particle | <chemistry> A tiny mass of material. Origin: L. Particula, dim. Of pars = part (18 Nov 1997) |
| particle accelerators | Devices which accelerate electrically charged atomic or subatomic particles, such as electrons, protons or ions, to high velocities so they have high kinetic energy. (12 Dec 1998) |
| particle fluence | <chemistry, radiobiology> at a given point in space, the sum of energies, the number of particles or photons incident during a given time interval on a small sphere centreed at that point, divided by the cross-sectional area of that sphere. It is identical with the time integral of the particle flux density. (16 Dec 1997) |
| charged particle | <radiobiology> A particle which carries a positive or negative electrical charge. In plasma physics, this typically means an ionised atom or molecule, or an electron. (09 Oct 1997) |
| core particle | The group of eight histones (protein molecules which act like spools for DNA to wrap around so that it can be compacted to fit within the nucleus) in the middle of a nucleosome (which is the histone core particle plus the small segment of DNA wrapped around it). (09 Oct 1997) |
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