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FKBP FK 506 [macrolide] binding protein
AAC antibiotic-associated [pseudomembranous] colitis; antimicrobial agent-induced colitis; augmentative ...
AAD acute agitated delirium; alloxazine adenine dinucleotide; alpha-1-antitrypsin deficiency; American A...
AAPC antibiotic-associated pseudomembranous colitis
AAPMC antibiotic-associated pseudomembranous colitis
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MLS Macrolide-lincosamide-streptogramin B
MLS macrolide-lincosamide-streptogramin
MLS(B) macrolide-lincosamide-streptogramin B
AAD Antibiotic associated diarrhea
AAC Antibiotic-associated colitis
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antibiotics, macrolide A group of antibiotics containing a macrocyclic lactone ring linked glycosidically to one or more sugar moieties. These antibiotics are produced by certain species of streptomyces. They often inhibit protein synthesis by binding to the 50s subunits of 70s ribosomes.
(12 Dec 1998)
macrolide <pharmacology> A group of antibiotics produced by various strains of Streptomyces that have a complex macrocyclic structure.
They inhibit protein synthesis by blocking the 50S ribosomal subunit. Include erythromycin, carbomycin. Used clinically as broad spectrum antibiotics, particularly against gram-positive bacteria.
(18 Nov 1997)
macrolide 2'-kinase <enzyme> Inducible intracellular enzyme which inactivates 14-member ring macrolides at the 2'-oh of the d-desosamine moiety; from an erythromycin-resistant strain of E coli; GTP, itp and ATP can also act as donors; mph(2')i is encoded by mpha and mrx, which have been sequenced
Registry number: EC 2.7.1.136
Synonym: oleandomycin 2'-phosphotransferase, macrolide 2'-phosphotransferase, macrolide 2'-phosphotransferase I, mph(2')i
(26 Jun 1999)
macrolide glycosyltransferase <enzyme> From streptomyces lividans; utilises udp-glucose as cofactor; substrates include macrolides with 12-, 14-, 15-, or 16-atom cyclic polyketide lactones; enzyme specific for the 2'-oh group of saccharide moieties attached to c-5 of the 16-atom lactone ring
Registry number: EC 2.4.1.-
Synonym: macrolide glucosyltransferase
(26 Jun 1999)
antibiotic <pharmacology> A chemical substance produced by a microorganism which has the capacity, in dilute solutions, to inhibit the growth of or to kill other microorganisms.
Antibiotics that are sufficiently nontoxic to the host are used as chemotherapeutic agents in the treatment of infectious diseases of man, animals and plants.
Origin: Gr. Bios = life
(18 Nov 1997)
antibiotic assay <investigation> A test to determine how sensitive a bacterial or fungal strain is to arange of antibiotics bymeasuring the microbes' ability to grow in astandard dilution of each chemical.
(09 Oct 1997)
antibiotic enterocolitis Enterocolitis caused by oral administration of broad spectrum antibiotics, resulting from overgrowth of antibiotic-resistant staphylococci or yeasts and fungi, when the normal faecal Gram-negative organisms are suppressed, resulting in diarrhoea or pseudomembranous disease.
(05 Mar 2000)
antibiotic eye drops <pharmacology> A medication that is pH balanced to allow placement into the eye for the purpose of killing bacteria.
Examples include: Bleph-10, Chloromycetin, Cortisporin-Ophthalmic, Gantrisin, Genoptic, Gentacidin, Garamycin, Gantrisin, Ilotycin, Sodium Sulamyd and Sulphair.
(27 Sep 1997)
antibiotic induced enteritis <pathology> A condition where the normal intestinal bacteria (useful for digestion) are killed by the use of an antibiotic resulting in symptoms.
(27 Sep 1997)
antibiotic induced gastroenteritis <pathology> A condition where the normal intestinal bacteria (useful for digestion) are killed by the use of an antibiotic resulting in symptoms.
(27 Sep 1997)
antibiotic ointment A ointment (or cream) based medication that kills bacteria.
Examples include Neosporin, Bactroban, Garamycin, bacitracin, gentamicin, mupirocin, neomycin, silver sulphasalazine, chloramphenicol and clindamycin.
(27 Sep 1997)
antibiotic prophylaxis Use of antibiotics before, during, or after a diagnostic, therapeutic, or surgical procedure to prevent infectious complications.
(12 Dec 1998)
antibiotic resistance The ability of a bacterium tosynthesise a protein that neutralises an antibiotic.
(09 Oct 1997)
antibiotic resistance gene Genes in a microorganism which confer resistance to antibiotics, for example by coding for enzymes which destroy it, by coding for surface proteins which prevent it from entering the microorganism, or by being a mutant form of the antibiotic's target so that it can ignore it.
(09 Oct 1997)
antibiotic-resistant Indicating microorganisms that continue to multiply although exposed to antibiotic agents.
(05 Mar 2000)
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