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MJ Machado-Joseph [disease]; marijuana; megajoule
MJAD Machado-Joseph Azorean disease
MJD Machado-Joseph disease; Mseleni joint disease
KMLE ÀÚµ¿ÃßÃâ ÀÇÇоà¾î »çÀü À¯»ç °Ë»ö °á°ú : 1 ÆäÀÌÁö: 1
MJD Machado Joseph Disease
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Machado-Guerreiro test A complement-fixation test for infection with Trypanosoma cruzi.
(05 Mar 2000)
Machado-Joseph A rare form of hereditary ataxia, characterised by onset in early adult life of progressive, spinocerebellar and extrapyramidal disease with external ophthalmoplegia, rigidity dystonia symptoms, and, often, peripheral amyotrophy; found predominantly in people of Azorean ancestry; autosomal dominant inheritance.
Synonym: Azorean disease, Portuguese-Azorean disease.
Origin: Surnames of two families studied in major descriptions of the disease.
(05 Mar 2000)
machado-joseph disease A progressive degenerative disease of the central nervous system occurring in portuguese-azorean families, having a variety of forms and inherited as an autosomal dominant trait. There are four major types: type I: with pyramidal and extrapyramidal deficits; type II: with cerebellar, pyramidal and extrapyramidal deficits; type III: with cerebellar deficits and distal sensorimotor neuropathy; type IV: with parkinsonism and distal sensory neuropathy. It was originally reported in two portuguese-azorean families in massachusettes (machado), then in another portuguese family (thomas), and later in a third family in california (joseph, who settled there in 1845). It has been reported also in japanese families.
(12 Dec 1998)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 1 ÆäÀÌÁö: 1
  • Machado-Joseph Disease - »õâ A dominantly-inherited ATAXIA first described in people of Azorean and Portuguese descent, and subsequently identified in Brazil, Japan, China, and Australia. This disorder is classified as one of the SPINOCEREBELLAR ATAXIAS (Type 3) and has been associated with a mutation of the MJD1 gene on chromosome 14. Clinical features include progressive ataxia, DYSARTHRIA, postural instability, nystagmus, eyelid retraction, and facial FASCICULATIONS. DYSTONIA is prominent in younger patients (referred to as Type I Machado-Joseph Disease). Type II features ataxia and ocular signs; Type III features MUSCULAR ATROPHY and a sensorimotor neuropathy; and Type IV features extrapyramidal signs combined with a sensorimotor neuropathy. (From Clin Neurosci 1995;3(1):17-22; Ann Neurol 1998 Mar;43(3):288-96)
    Synonyms : Autosomal Dominant Striatonigral Degeneration, Azorean Disease (Machado-Joseph), Azorean Disease, Nervous System, Joseph Azorean Disease, Machado-Joseph Azorean Disease, Machado-Joseph Disease Type I, Machado-Joseph Disease Type II, Spinocerebellar Ataxia-3
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Machado-Joseph disease Machado-Joseph disease, also known as spinocerebellar ataxia (SCA) type III, is probably the most common autosomal dominant SCA. This disorder was previously known as Azorean disease, as a large number of Portuguese families from the Azores Islands were found to be affected; however, SCA type III has now been reported in many other ethnic groups. In addition to unsteadiness of gait (ataxia), symptoms may involve parkinsonism, dystonia, and chorea. ...
Ãâó: www.dbs-stn.org/glossary2.asp
Machado r. see under test.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
Machado t. (for Chagas' disease): a complement-fixation test, using as antigen an extract of the spleen of puppies severely infected with Trypanosoma cruzi.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
Machado-Joseph d. Azorean d.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
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