| LA | lactic acid; large amount; laser angioplasty; late abortion; late antigen; latex agglutination; left... |
|---|---|
| AMCAS | American Medical College Application Service |
| ANDA | Abbreviated New Drug Application |
| appl | appliance; application, applied |
| COTRANS | Coordinated Transfer Application System |
| IND | Investigational New Drug Application |
|---|---|
| NDA | New Drug Application |
| PMA | Premarket Approval Application |
| ROAT | Repeated Open Application Test |
| EMLA | Eutectic Mixture of Local Anaesthetics |
| application | Employment as a means, specific use. (18 Nov 1997) |
|---|---|
| investigational new drug application | An application that must be submitted to a regulatory agency (the FDA in the united states) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (12 Dec 1998) |
| Establishment License Application | <pharmacology> An application submitted concurrently with the Product License Application. The Establishment Licence Application provides data demonstrating the acceptability of the facilities and personnel for manufacturing of protein pharmaceuticals. Acronym: ELA (14 Nov 1997) |
| job application | Process of applying for employment. It includes written application for employment or personal appearance. (12 Dec 1998) |
| anaesthesia, local | Anaesthesia confined to one part of the body. Infiltration anaesthesia produces local anaesthesia by deposition of a local anaesthesia solution in the area of small, terminal nerve endings. (12 Dec 1998) |
| anaesthetics, local | Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fibre. In contact with a nerve trunk, these anaesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. Nearly all local anaesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. They are commonly used not only in the peripheral nervous system, but also for spinal anaesthesia. The many drugs that have local anaesthetic actions as a side effect but are not used for their local anaesthetic action are not included here. (12 Dec 1998) |
| anti-infective agents, local | Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from disinfectants, which are used on inanimate objects. (12 Dec 1998) |
| neoplasm recurrence, local | The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site. (12 Dec 1998) |
| local | Restricted to or pertaining to one spot or part, not general. Origin: L. Localis (18 Nov 1997) |
| local anaemia | Anaemia resulting from a decreased supply of blood to a part, as in the occlusion of a vessel. (05 Mar 2000) |
| local anaesthesia | The use of a local anaesthetic (usually injected into the tissue) results in a small region of anaesthesia (numbness). Lidocaine (Xylocaine) or (Marcaine) are commonly used. Origin: Gr. Aisthesis = sensation (27 Sep 1997) |
| local anaesthetic | The use of a local anaesthetic (usually injected into the tissue) results in a small region of anaesthesia (numbness). Lidocaine (Xylocaine) or (Marcaine) are commonly used. (27 Sep 1997) |
| local anaesthetic reaction | A toxic reaction due to absorption of local anaesthetic drug during regional anaesthesia, ranging from drowsiness to convulsions and cardiovascular collapse. (05 Mar 2000) |
| local anaesthetics | Drugs used for the interruption of the nerve transmission of pain sensations. They act at the site of application to prevent perception of pain; examples include procaine and lidocaine. (05 Mar 2000) |
| local anaphylaxis | The immediate, transient kind of response that follows the injection of antigen (allergen) into the skin of a sensitised individual and is limited to the area surrounding the site of inoculation. See: skin test. (05 Mar 2000) |
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