| MAOI | MonoAmine Oxidase Inhibitors |
|---|---|
| FLAP | 5-lipoxygenase activating protein |
| LOG | lipoxygenase |
| AChE-I | acetylcholine esterase inhibitors |
|---|---|
| ChEI | Cholinesterase inhibitors |
| IAPs | Inhibitors of apoptosis |
| NNRTI | Non nucleoside reverse transcriptase inhibitors |
| PAI | Plasminogen Activator Inhibitors |
| lipoxygenase inhibitors | Compounds or agents that combine with lipoxygenase and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of the eicosanoid products hydroxyeicosatetraenoic acid and various leukotrienes. (12 Dec 1998) |
|---|
| arachidonate 12-lipoxygenase | <enzyme> An enzyme that catalyses the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-hpete) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-hete). The 12-hydroperoxides are preferentially formed in platelets. Chemical name: Arachidonate:oxygen 12-oxidoreductase Registry number: EC 1.13.11.31 (12 Dec 1998) |
|---|---|
| arachidonate 15-lipoxygenase | <enzyme> An enzyme that catalyses the oxidation of arachidonic acid to yield 15-hydroperoxyarachidonate (15-hpete) which is rapidly converted to 15-hydroxy-5,8,11,13-eicosatetraenoate (15-hete). The 15-hydroperoxides are preferentially formed in neutrophils and lymphocytes. Chemical name: Arachidonate:oxygen 15-oxidoreductase Registry number: EC 1.13.11.33 (12 Dec 1998) |
| arachidonate 5-lipoxygenase | <enzyme> An enzyme that catalyses the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-hpete) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-hete). The 5-hydroperoxides are preferentially formed in leukocytes. Chemical name: Arachidonate:oxygen 5-oxidoreductase Registry number: EC 1.13.11.34 (12 Dec 1998) |
| arachidonate 8-lipoxygenase | <enzyme> From sea whip coral plexaura homomalla; catalyses the conversion of arachidonic acid to a cyclised prostanoid with a pga ring and the same side chains as the parent arachidonate Registry number: EC 1.13.11.40 Synonym: 8(r)-lipoxygenase, 8-lipoxygenase (26 Jun 1999) |
| 11-lipoxygenase | <enzyme> Sea urchin egg enzyme converts arachidonic acid to 11(r)-hydroperoxyeicosapentaenoic acid Registry number: EC 1.13.11.- Synonym: (11r)-lipoxygenase (26 Jun 1999) |
| lipoxygenase | <enzyme> Enzyme that catalyses the oxidative conversion of arachidonic acid to the hydroxyeicosenoic acid (HETE) structure in the synthesis of leucotrienes. (18 Nov 1997) |
| adrenergic uptake inhibitors | Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (antidepressive agents, tricyclic) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (12 Dec 1998) |
| blood coagulation factor inhibitors | Substances, usually endogenous, that act as inhibitors of blood coagulation. They may affect one or multiple enzymes throughout the process. As a group, they also inhibit enzymes involved in processes other than blood coagulation, such as those from the complement system, fibrinolytic enzyme system, blood cells, and bacteria. (12 Dec 1998) |
| Bowman Birk protease inhibitors | <pharmacology> Family of serine protease inhibitors found in seeds of leguminous plants and cereals. (18 Nov 1997) |
| carbonic anhydrase inhibitors | A class of compounds that reduces the secretion of h+ ions by the proximal kidney tubule through inhibition of carbonic anhydrase (carbonate dehydratase). Although their therapeutic use as diuretics is not frequent, they are used in clinical conditions where alkalinization of the urine is beneficial. Their most frequent application is in the reduction of intra-ocular pressure in the treatment of glaucoma. (12 Dec 1998) |
| reverse transcriptase inhibitors | Inhibitors of reverse transcriptase (RNA-directed DNA polymerase), an enzyme that synthesises DNA on an RNA template. (12 Dec 1998) |
| growth inhibitors | Endogenous or exogenous substances which inhibit the normal growth of human and animal cells or micro-organisms, as distinguished from those affecting plant growth (= plant growth regulators). (12 Dec 1998) |
| phosphodiesterase inhibitors | Compounds which inhibit or antagonise the biosynthesis or actions of phosphodiesterases. (12 Dec 1998) |
| monoamine oxidase inhibitors | A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. Although mao inhibitors are probably as effective as tricyclic antidepressants in the treatment of major depression, the complex, sometimes severe, and often unpredictable interactions between mao inhibitors and many other drugs and food-derived amines make their medical use difficult and potentially hazardous. (12 Dec 1998) |
| platelet aggregation inhibitors | Drugs or agents which antagonise or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (12 Dec 1998) |
Synonyms : Inhibitors, Lipoxygenase
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