| ¿µ¹® | diabetic nephropathy | ÇÑ±Û | ´ç´¢º´ÄáÆÏº´Áõ |
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| VL | variable domain of the light chain; variable light chain |
|---|---|
| LM | lactic acid mineral [medium]; lactose malabsorption; laryngeal mask; laryngeal muscle; lateral malle... |
| LS | lateral suspensor; left sacrum; left septum; left side; legally separated; leiomyosarcoma; length of... |
| AAN | AIDS-associated nephropathy; alpha-amino nitrogen; American Academy of Neurology; American Academy o... |
| kappa | a light chain of human immunoglobulins [chain] |
| L-chain | Light-chain |
|---|---|
| IgL | Immunoglobulin light chain |
| LCDD | K-light chain deposition disease |
| LC3 | Light chain 3 |
| MLCK | Myosin Light Chain Kinase |
| gene rearrangement, b-lymphocyte, light chain | Ordered rearrangement of b-lymphocyte variable gene regions coding for the kappa or lambda light chains, thereby contributing to antibody diversity. It occurs during the second stage of differentiation of the immature b-lymphocyte. (12 Dec 1998) |
|---|---|
| P light chain | <protein> Myosin light chain that can be phosphorylated by myosin light chain kinase, as a result of phosphorylation, the myosin is activated. (18 Nov 1997) |
| myosin light chain | <protein> The light chains of the muscle protein myosin. Each molecule of myosin is composed of two heavy chains and two pairs of light chains. The light chains have a molecular weight of about 20 kD and there is one dissimilar pair of light chains associated with each heavy chain. The proteins all have sequence homology to calmodulin, but not all with calcium binding activity. Several types are known: regulatory light chains (LC 2, DNTB light chains) probably regulate the ATPase activity of the heavy chain directly (through the binding of calcium) or indirectly (activating when they themselves are phosphorylated by myosin light chain kinase) and essential light chains (LC 1, LC 3, alkali light chains), which have a more subtle and apparently nonessential role. In molluscan muscle the EDTA light chains (similar to LC 2 from vertebrate muscle) confer calcium sensitivity on the myosin itself. The light chains are "calmodulin-like" proteins that bind calcium. Two of them can be removed easily, and two with difficulty. The light chains bind the heavy chains in the vicinity of the head groups of the myosin. (12 Dec 1998) |
| myosin light chain kinase | <enzyme> An enzyme that phosphorylates myosin light chains in the presence of ATP to yield myosin-light chain phosphate and ADP, and requires calcium and calmodulin. The 20-kD light chain is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors. The enzyme plays a central role in the regulation of smooth muscle contraction. Chemical name: ATP:myosin-light-chain O-phosphotransferase Registry number: EC 2.7.1.117 (12 Dec 1998) |
| immunoglobulins, light-chain | Polypeptide chains, consisting of 211 to 217 amino acid residues, isolated from immunoglobulins and having a molecular weight of approximately 22 kD. There are two major types of light chains, kappa and lambda. In man they are found in a ratio of 60% to 40%, respectively. Both chains consist of linear repeating, similar, but not identical, segments of about 110 amino acid residues. In each segment a disulfide bond establishes a tightly folded approximately 60-membered loop or domain. Adjacent domains are linked by less tightly folded regions. Both light chains contain two such domains. Two light and two heavy chains make one immunoglobulin molecule, but both light chains in one ig are of the same type. (12 Dec 1998) |
| EDTA light chain | <protein> Myosin light chains (18 kD) from scallop muscle (two per pair of heavy chains), easily extracted by calcium chelation. Although the EDTA light chains do not bind calcium they confer calcium sensitivity on the myosin heavy chains. (18 Nov 1997) |
| light chain | <immunology, protein> The lighter of the two types of polypeptide chains that are found in immunoglobulin and antibody molecules. Also used as a non-specific term for the smaller subunits of several multimeric proteins such as immunoglobulin, myosin, dynein, clathrin. (14 Oct 1997) |
| light chain-related amyloidosis | A form of primary amyloidosis in which the fibrillar amyloid deposits are derived from the amino terminal variable region of the light chains of immunoglobulin; seen in B-lymphocyte and plasma-cells dyscrasias. (05 Mar 2000) |
| chain, orthodontic chain | <dentistry> A stretchable plastic chain used to hold archwires into brackets and to moke teeth. (08 Jan 1998) |
| aids-associated nephropathy | Renal syndrome in human immunodeficiency virus-infected patients characterised by nephrotic syndrome, severe proteinuria, focal and segmental glomerulosclerosis with distinctive tubular and interstitial changes, enlarged kidneys, and peculiar tubuloreticular structures. The syndrome is distinct from heroin-associated nephropathy as well as other forms of kidney disease seen in HIV-infected patients. (12 Dec 1998) |
| analgesic nephropathy | <nephrology, pathology> A form of kidney damage which can occur from the overexposure to certain analgesics (for example acetaminophen, salicylates and non-steroidal anti-inflammatory agents). In most cases analgesic use is excessive in dosing or chronicity of use. Complications include acute renal failure. See: interstitial nephritis. Origin: Gr. Pathos = disease (27 Sep 1997) |
| balkan nephropathy | A tubulointerstitial disease of unknown aetiology occurring in a limited geographic area including adjacent regions of romania, bulgaria, and yugoslavia. (12 Dec 1998) |
| reflux nephropathy | <nephrology> A condition where the chronic backup of urine into a kidney results in kidney damage. Urine is forced out of the bladder and back toward kidney. This condition occurs most commonly in children who have congenital abnormalities of the urinary tract. Symptoms include back pain, flank, pain, abdominal pain, urinary frequency or urgency and blood in the urine. Other symptoms include nausea, fever and chills, most often indicating a kidney infection has occurred. Diagnosis is frequently confirmed by voiding cystourethrogram. Surgery is often required to correct the reflux of urine. Origin: Gr. Pathos = disease (27 Sep 1997) |
| membranous nephropathy | <pathology> A kidney disease that occurs due to inflammation of the kidney glomerulus and its basement membrane. The exact cause is unknown but it appears to be related to the deposition of immune complexes in the basement membrane leading to thickening of the capillary walls. This disorder is a common cause of nephrotic syndrome an is usually how the disease manifests. Risk factors include primary renal disease, malaria, hepatitis B, lupus, syphilis, cancers and non-Hodgkin's lymphomas. Risks also include exposure to some medications such as gold compounds and penicillamine. Mercury, trimethadione and some skin-lightening creams have also been implicated. Treatment includes systemic corticosteroids and immunosuppressive agents. (26 Mar 1998) |
| hereditary deafness and nephropathy | <nephrology, pathology> An inherited disorder involving damage to the kidneys, haematuria and hearing loss. In some individuals vision may also be affected. This genetic disease is uncommon. Symptoms include loss of hearing, abnormal colour to urine, swelling, cough and decline in vision. Inheritance: sex-linked autosomal dominant. Incidence: 1 in 50,000. Origin: Gr. Pathos = disease (27 Sep 1997) |
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