| SIH | stimulation-induced hypalgesia; stress-induced hyperthermia; suction-induced hypoxemia |
|---|---|
| CLD | chloride diarrhea; chronic liver disease; chronic lung disease; congenital limb deficiency; crystal ... |
| MLC | minimum lethal concentration; mixed leukocyte culture; mixed ligand chelate; mixed lymphocyte concen... |
| MLCT | metal-to-ligand charge transfer |
| DIT | deferoxamine infusion test; diet-induced thermogenesis; diiodotyrosine; drug-induced thrombocytopeni... |
| RME | Receptor-mediated endocytosis |
|---|---|
| LIBS | Ligand-induced binding sites |
| APO2L | AP02 ligand |
| CD30L | CD30 ligand |
| CD40L | CD40 Ligand |
| ligand induced endocytosis | The formation of coated pits and then coated vesicles as a consequence of the interaction of ligand with receptors, which then interact with clathrin and associated proteins (coatomers) on the cytoplasmic face of the plasma membrane and come together to form a pit. Not all coated vesicle uptake of receptors requires receptor occupancy. (18 Nov 1997) |
|---|
| receptor mediated endocytosis | Endocytosis of molecules by means of a specific receptor protein that normally resides in a coated pit, but may enter this structure after complex formation occurs. The structure then forms a coated vesicle that delivers its contents to the endosome whence it may enter the cytoplasm or the lysosomal compartment. Many bacterial toxins and viruses enter cells by this route. (18 Nov 1997) |
|---|---|
| endocytosis | Uptake of material into a cell by the formation of a membrane bound vesicle. (18 Nov 1997) |
| ambident ligand | <chemistry> A ligand that can donate electrons through two or more atoms on their molecule. (05 Feb 1998) |
| cyanocobalamin beta-ligand transferase | <enzyme> Cytosolic enzyme utilizing fad, NADPH and reduced glutathione; forms glutathionylcobalamin from cyanocobalamin Registry number: EC 2.5.1.- Synonym: ccbl transferase (26 Jun 1999) |
| ELAM-1 ligand fucosyltransferase | <enzyme> Directs the expression of an elam-1 ligand; an alpha(1,3) fucosyltransferase Registry number: EC 2.4.1.- Synonym: elft protein, elft gene product (26 Jun 1999) |
| ligand | <chemistry, immunology> Any molecule that binds to another, in normal usage a soluble molecule such as a hormone or neurotransmitter, that binds to a receptor. The decision as to which is the ligand and which the receptor is often a little arbitrary when the broader sense of receptor is used (where there is no implication of transduction of signal). In these cases it is probably a good rule to consider the ligand to be the smaller of the two thus in a lectin sugar interaction, the sugar would be the ligand (even though it is attached to a much larger molecule, recognition is of the saccharide). (18 Nov 1997) |
| ligand binding site | The site on a protein's surface that binds a ligand; equivalent to the active site if the ligand is the substrate of an enzyme. (05 Mar 2000) |
| ligand-gated channel | A class of ion channel's whose ionic permeability is regulated by cell membrane receptors that respond to specific extracellular chemical signals. (05 Mar 2000) |
| ligand gated ion channel | A transmembrane ion channel whose permeability is increased by the binding of a specific ligand, typically a neurotransmitter at a chemical synapse. The permeability change is often drastic, such channels let through effectively no ions when shut, but allow passage at up to 10exp7 ions sexp 1 when a ligand is bound. Recently, the receptors for both acetylcholine and GABA have been found to share considerable sequence homology, implying that there may be a family of structurally related ligand gated ion channels. (18 Nov 1997) |
| abnormalities, drug-induced | Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment. (12 Dec 1998) |
| abnormalities, radiation-induced | Congenital changes in the morphology of organs produced by exposure to ionizing or non-ionizing radiation. (12 Dec 1998) |
| abortion, induced | Intentional removal of a foetus from the uterus by any of a number of techniques. (popline, 1978) (12 Dec 1998) |
| akathisia, drug-induced | Motor restlessness with sensations of quivering and an urge to move about constantly resulting from the use of certain drugs, such as neuroleptic drugs, which affect the extrapyramidal region of the brain. This differs from dyskinesia, drug-induced in that long-term antipsychotic drug exposure is significantly correlated with the increased prevalence of akathisia while there is no such correlation with dyskinesia. The primary observable distinction between tardive akathisia and dyskinesia appears to be in the repetitive, stereotypy of the dyskinesic movements (lip smacking, for example), while akathisia is associated with anxiety, restlessness, and agitation (psychomotor agitation). (12 Dec 1998) |
| alpha-chymotrypsin-induced glaucoma | Transient secondary glaucoma following the use of alpha-chymotrypsin in cataract extraction. (05 Mar 2000) |
| antibiotic induced enteritis | <pathology> A condition where the normal intestinal bacteria (useful for digestion) are killed by the use of an antibiotic resulting in symptoms. (27 Sep 1997) |
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